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• W4284959031 abstract "Abstract Background and Aims Inflammatory bowel disease [IBD], consisting of Crohn’s disease [CD] and ulcerative colitis [UC], is a relapsing-remitting illness. Treat-to-target IBD management strategies require monitoring of gastrointestinal inflammation. This study aimed to investigate faecal myeloperoxidase [fMPO], a neutrophil granule enzyme, as a biomarker of IBD activity. Methods Prospectively recruited participants with IBD, undergoing ileocolonoscopy for disease assessment, provided biological samples and completed symptom questionnaires prior to endoscopy. fMPO, C-reactive protein [CRP], and faecal calprotectin [fCal] were compared with validated endoscopic indices [simple endoscopic score for CD and UC endoscopic index of severity]. Receiver operating characteristic [ROC] curves assessed the performance of fMPO, CRP, and fCal in predicting endoscopic disease activity. Baseline biomarkers were used to predict a composite endpoint of complicated disease at 12 months [need for escalation of biologic/immunomodulator due to relapse, steroid use, IBD-related hospitalisation, and surgery]. Results A total of 172 participants were recruited [91 female, 100 with CD]. fMPO was significantly correlated with endoscopic activity in both CD [r = 0.53, p &lt; 0.01] and UC [r = 0.63, p &lt; 0.01], and with fCal in all patients with IBD [r = 0.82, p &lt; 0.01]. fMPO was effective in predicting moderate-to-severely active CD [AUROC 0.86, p &lt; 0.01] and UC [AUROC 0.92, p &lt; 0.01]. Individuals with a baseline fMPO &gt; 26 µg/g were significantly more likely to reach the composite outcome at 12 months (hazard ratio [HR] 3.71, 95% confidence interval [CI] 2.07–6.64, p &lt; 0.01). Conclusions Faecal myeloperoxidase is an accurate biomarker of endoscopic activity in IBD and predicted a more complicated IBD course during follow-up." @default.
• W4284959031 created "2022-07-10" @default.
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• W4284959031 date "2022-07-08" @default.
• W4284959031 modified "2023-09-26" @default.
• W4284959031 title "Faecal Myeloperoxidase as a Biomarker of Endoscopic Activity in Inflammatory Bowel Disease" @default.
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• W4284959031 doi "https://doi.org/10.1093/ecco-jcc/jjac098" @default.
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