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- W4284959891 abstract "We previously combined reduced graphene oxide (rGO) with gelatin-methacryloyl (GelMA) and polycaprolactone (PCL) to create an rGO-GelMA-PCL nerve conduit and found that the conductivity and biocompatibility were improved. However, the rGO-GelMA-PCL nerve conduits differed greatly from autologous nerve transplants in their ability to promote the regeneration of injured peripheral nerves and axonal sprouting. Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSCs) can be loaded into rGO-GelMA-PCL nerve conduits for repair of rat sciatic nerve injury because they can promote angiogenesis at the injured site. In this study, 12 weeks after surgery, sciatic nerve function was measured by electrophysiology and sciatic nerve function index, and myelin sheath and axon regeneration were observed by electron microscopy, immunohistochemistry, and immunofluorescence. The regeneration of microvessel was observed by immunofluorescence. Our results showed that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles were superior to rGO-GelMA-PCL conduits alone in their ability to increase the number of newly formed vessels and axonal sprouts at the injury site as well as the recovery of neurological function. These findings indicate that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles can promote peripheral nerve regeneration and neurological function recovery, and provide a new direction for the curation of peripheral nerve defect in the clinic." @default.
- W4284959891 created "2022-07-10" @default.
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- W4284959891 date "2023-01-01" @default.
- W4284959891 modified "2023-09-30" @default.
- W4284959891 title "Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration" @default.
- W4284959891 cites W118206049 @default.
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- W4284959891 cites W1877686344 @default.
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- W4284959891 cites W1997044378 @default.
- W4284959891 cites W2027191853 @default.
- W4284959891 cites W2031921408 @default.
- W4284959891 cites W2035176325 @default.
- W4284959891 cites W2036348189 @default.
- W4284959891 cites W2041302930 @default.
- W4284959891 cites W2045178014 @default.
- W4284959891 cites W2058180357 @default.
- W4284959891 cites W2077406393 @default.
- W4284959891 cites W2081100505 @default.
- W4284959891 cites W2084693500 @default.
- W4284959891 cites W2091562888 @default.
- W4284959891 cites W2118661742 @default.
- W4284959891 cites W2140573520 @default.
- W4284959891 cites W2161042757 @default.
- W4284959891 cites W2211541075 @default.
- W4284959891 cites W2240098740 @default.
- W4284959891 cites W2262985044 @default.
- W4284959891 cites W2344944109 @default.
- W4284959891 cites W2419151490 @default.
- W4284959891 cites W2482259188 @default.
- W4284959891 cites W2577152267 @default.
- W4284959891 cites W2581455542 @default.
- W4284959891 cites W2605484523 @default.
- W4284959891 cites W2605897077 @default.
- W4284959891 cites W2607362025 @default.
- W4284959891 cites W2622496233 @default.
- W4284959891 cites W2740894127 @default.
- W4284959891 cites W2742788054 @default.
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- W4284959891 cites W2915270257 @default.
- W4284959891 cites W2943150116 @default.
- W4284959891 cites W2952192630 @default.
- W4284959891 cites W2970026792 @default.
- W4284959891 cites W2976973875 @default.
- W4284959891 cites W2980312160 @default.
- W4284959891 cites W2981040947 @default.
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- W4284959891 doi "https://doi.org/10.4103/1673-5374.343889" @default.
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