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- W4284960558 endingPage "1253" @default.
- W4284960558 startingPage "1241" @default.
- W4284960558 abstract "Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics that seek to overcome the low therapeutic index of conventional cytotoxic agents. However, realizing this goal has been a significant challenge. ADCs comprise several independently modifiable components, including the antibody, payload, linker, and bioconjugation method. Many approaches have been developed to improve the physical properties, potency, and selectivity of ADCs. The anti-HER-2 antibody trastuzumab, first approved in 1998, has emerged as an exceptional targeting agent for ADCs, as well as a broadly used platform for testing new technologies. The extensive work in this area enables the comparison of various linker strategies, payloads, drug-to-antibody ratios (DAR), and mode of attachment. In this review, these conjugates, ranging from the first clinically approved trastuzumab ADC, ado-trastuzumab emtansine (Kadcyla), to the latest variants are described with the goal of providing a broad overview, as well as enabling the comparison of existing and emerging conjugate technologies." @default.
- W4284960558 created "2022-07-10" @default.
- W4284960558 creator A5013638352 @default.
- W4284960558 creator A5015940099 @default.
- W4284960558 creator A5074276813 @default.
- W4284960558 creator A5075404397 @default.
- W4284960558 creator A5076905662 @default.
- W4284960558 date "2022-07-08" @default.
- W4284960558 modified "2023-10-15" @default.
- W4284960558 title "Structure–Activity Relationships of Antibody-Drug Conjugates: A Systematic Review of Chemistry on the Trastuzumab Scaffold" @default.
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