FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284962080> ?p ?o ?g. }

• W4284962080 abstract "HIV variants present in the reservoir, particularly in tissues, may differ from those present in peripheral blood prior to therapy initiation, and characterisation of these reservoir variants could better inform immune-based interventions for HIV cure. In the present study, Gag sequence differences between variants derived from the lymph node and peripheral blood mononuclear cell (PBMC) reservoirs as well as those derived from pre-therapy plasma, were investigated in 24 HIV-1 subtype C-infected individuals. HIV gag amplification was successful for 20 individuals, where 4 were controls including one untreated individual and 3 early treated individuals with LN collection within 2 weeks of treatment initiation. The remaining 16 individuals with LN and PBMC collection &gt; 3 months after treatment initiation (median = 665 days), were further characterised. Recombinant viruses encoding patient-derived Gag-protease sequences from the pre-therapy plasma, LN reservoir, and PBMC reservoir, were constructed and the replication-competent viruses that grew in vitro were used to further investigate whether there are specific features of Gag reservoir variants that may have relevance for strategies to cure HIV. Virus characteristics measured included replication capacity, interferon-alpha resistance, cell-to-cell spread ability, and induction of antiviral cytokines. A limited number of novel Gag mutations (median = 4) in the reservoir of 3/7 early treated participants and 9/9 late treated participants were observed, where the majority of these mutations were likely cytotoxic T lymphocyte (CTL)-driven and 48% were represented in the replication-competent viruses. The reservoir variants had very few unique potential CTL escape mutations (median = 3) in Gag compared to the number of these Gag mutations that were already present in the plasma-derived virus (median = 23) at the time of treatment initiation, which was similar whether treatment was initiated late or early. The data suggest that the extent of CTL escape in Gag overall is likely similar between early and late treated individuals as well as between the reservoir and pre-therapy variants. The sequence differences in Gag that were unique to the reservoir viruses did not result in significantly altered virus characteristics overall, and are therefore unlikely to affect effectiveness of immune-based interventions for virus eradication." @default.
• W4284962080 created "2022-07-10" @default.
• W4284962080 creator A5009331979 @default.
• W4284962080 creator A5012515336 @default.
• W4284962080 creator A5017060304 @default.
• W4284962080 creator A5031433567 @default.
• W4284962080 creator A5040659613 @default.
• W4284962080 creator A5040954811 @default.
• W4284962080 creator A5044055108 @default.
• W4284962080 creator A5068747796 @default.
• W4284962080 creator A5081435008 @default.
• W4284962080 creator A5088371341 @default.
• W4284962080 creator A5088690448 @default.
• W4284962080 date "2022-07-08" @default.
• W4284962080 modified "2023-10-01" @default.
• W4284962080 title "Limited Sequence Variation and Similar Phenotypic Characteristics of HIV-1 Subtype C Gag Variants Derived From the Reservoir and Pre-Therapy Plasma" @default.
• W4284962080 cites W162579416 @default.
• W4284962080 cites W1849393705 @default.
• W4284962080 cites W1960675081 @default.
• W4284962080 cites W1977929936 @default.
• W4284962080 cites W1979596307 @default.
• W4284962080 cites W1980915827 @default.
• W4284962080 cites W1982011825 @default.
• W4284962080 cites W1984811742 @default.
• W4284962080 cites W1994476715 @default.
• W4284962080 cites W2001766969 @default.
• W4284962080 cites W2005141763 @default.
• W4284962080 cites W2007089157 @default.
• W4284962080 cites W2014893636 @default.
• W4284962080 cites W2026615262 @default.
• W4284962080 cites W2032023518 @default.
• W4284962080 cites W2032722583 @default.
• W4284962080 cites W2043293085 @default.
• W4284962080 cites W2047385553 @default.
• W4284962080 cites W2051807614 @default.
• W4284962080 cites W2064140898 @default.
• W4284962080 cites W2075106941 @default.
• W4284962080 cites W2077915242 @default.
• W4284962080 cites W2084001707 @default.
• W4284962080 cites W2085384576 @default.
• W4284962080 cites W2089692155 @default.
• W4284962080 cites W2099272076 @default.
• W4284962080 cites W2099296320 @default.
• W4284962080 cites W2105028368 @default.
• W4284962080 cites W2107479692 @default.
• W4284962080 cites W2111211467 @default.
• W4284962080 cites W2122725362 @default.
• W4284962080 cites W2124571773 @default.
• W4284962080 cites W2136958613 @default.
• W4284962080 cites W2140193569 @default.
• W4284962080 cites W2140380019 @default.
• W4284962080 cites W2143564316 @default.
• W4284962080 cites W2165091593 @default.
• W4284962080 cites W2171223785 @default.
• W4284962080 cites W2196026454 @default.
• W4284962080 cites W2230157244 @default.
• W4284962080 cites W2392923505 @default.
• W4284962080 cites W2411771969 @default.
• W4284962080 cites W2560661532 @default.
• W4284962080 cites W2570006560 @default.
• W4284962080 cites W2619089341 @default.
• W4284962080 cites W2736730505 @default.
• W4284962080 cites W2753290949 @default.
• W4284962080 cites W2787954671 @default.
• W4284962080 cites W2795788543 @default.
• W4284962080 cites W2805966967 @default.
• W4284962080 cites W2807106468 @default.
• W4284962080 cites W2837980584 @default.
• W4284962080 cites W2903834810 @default.
• W4284962080 cites W2952458008 @default.
• W4284962080 cites W2964495532 @default.
• W4284962080 cites W2970368853 @default.
• W4284962080 cites W2972847840 @default.
• W4284962080 cites W2975857794 @default.
• W4284962080 cites W3012445050 @default.
• W4284962080 cites W3023923910 @default.
• W4284962080 cites W3091608615 @default.
• W4284962080 cites W3119673732 @default.
• W4284962080 cites W3147310958 @default.
• W4284962080 cites W4205179193 @default.
• W4284962080 cites W4313347724 @default.
• W4284962080 doi "https://doi.org/10.3389/fviro.2022.916095" @default.
• W4284962080 hasPublicationYear "2022" @default.
• W4284962080 type Work @default.
• W4284962080 citedByCount "0" @default.
• W4284962080 crossrefType "journal-article" @default.
• W4284962080 hasAuthorship W4284962080A5009331979 @default.
• W4284962080 hasAuthorship W4284962080A5012515336 @default.
• W4284962080 hasAuthorship W4284962080A5017060304 @default.
• W4284962080 hasAuthorship W4284962080A5031433567 @default.
• W4284962080 hasAuthorship W4284962080A5040659613 @default.
• W4284962080 hasAuthorship W4284962080A5040954811 @default.
• W4284962080 hasAuthorship W4284962080A5044055108 @default.
• W4284962080 hasAuthorship W4284962080A5068747796 @default.
• W4284962080 hasAuthorship W4284962080A5081435008 @default.
• W4284962080 hasAuthorship W4284962080A5088371341 @default.
• W4284962080 hasAuthorship W4284962080A5088690448 @default.
• W4284962080 hasBestOaLocation W42849620801 @default.
• W4284962080 hasConcept C137061746 @default.
• W4284962080 hasConcept C140704245 @default.

• next