Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284968098> ?p ?o ?g. }
- W4284968098 abstract "Abstract The transition zone (TZ) of the cilium/flagellum serves as a diffusion barrier that controls the entry/exit of ciliary proteins. Mutations of the TZ proteins disrupt barrier function and lead to multiple human diseases. However, the systematic regulation of ciliary composition and signaling-related processes by different TZ proteins is not completely understood. Here, we reveal that loss of TCTN1 in Chlamydomonas reinhardtii disrupts the assembly of wedge-shaped structures in the TZ. Proteomic analysis of cilia from WT and three TZ mutants, tctn1 , cep290 , and nphp4 , shows a unique role of each TZ subunit in the regulation of ciliary composition, explaining the phenotypic diversity of different TZ mutants. Interestingly, we find that defects in the TZ impair the formation and biological activity of ciliary ectosomes. Collectively, our findings provide systematic insights into the regulation of ciliary composition by TZ proteins and reveal a link between the TZ and ciliary ectosomes." @default.
- W4284968098 created "2022-07-10" @default.
- W4284968098 creator A5010350753 @default.
- W4284968098 creator A5012138915 @default.
- W4284968098 creator A5019122793 @default.
- W4284968098 creator A5024662281 @default.
- W4284968098 creator A5030976623 @default.
- W4284968098 creator A5031897845 @default.
- W4284968098 creator A5048157560 @default.
- W4284968098 creator A5050664289 @default.
- W4284968098 creator A5052504607 @default.
- W4284968098 creator A5060426175 @default.
- W4284968098 creator A5067679706 @default.
- W4284968098 creator A5077646117 @default.
- W4284968098 creator A5089890216 @default.
- W4284968098 date "2022-07-09" @default.
- W4284968098 modified "2023-10-18" @default.
- W4284968098 title "Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding" @default.
- W4284968098 cites W1571387405 @default.
- W4284968098 cites W1809267070 @default.
- W4284968098 cites W1889489351 @default.
- W4284968098 cites W1915536483 @default.
- W4284968098 cites W1973670059 @default.
- W4284968098 cites W1977603129 @default.
- W4284968098 cites W1984750217 @default.
- W4284968098 cites W1985225356 @default.
- W4284968098 cites W1987529702 @default.
- W4284968098 cites W1989704554 @default.
- W4284968098 cites W2035252153 @default.
- W4284968098 cites W2038678925 @default.
- W4284968098 cites W2041964741 @default.
- W4284968098 cites W2054131393 @default.
- W4284968098 cites W2054954402 @default.
- W4284968098 cites W2066323961 @default.
- W4284968098 cites W2074458710 @default.
- W4284968098 cites W2094911558 @default.
- W4284968098 cites W2099247534 @default.
- W4284968098 cites W2108007149 @default.
- W4284968098 cites W2121042424 @default.
- W4284968098 cites W2126339304 @default.
- W4284968098 cites W2127360608 @default.
- W4284968098 cites W2129394277 @default.
- W4284968098 cites W2134921841 @default.
- W4284968098 cites W2139989255 @default.
- W4284968098 cites W2146343693 @default.
- W4284968098 cites W2147335094 @default.
- W4284968098 cites W2166977115 @default.
- W4284968098 cites W2169459926 @default.
- W4284968098 cites W2177564588 @default.
- W4284968098 cites W2180541157 @default.
- W4284968098 cites W2299076631 @default.
- W4284968098 cites W2307400092 @default.
- W4284968098 cites W2316707639 @default.
- W4284968098 cites W2538387512 @default.
- W4284968098 cites W2549998959 @default.
- W4284968098 cites W2556920954 @default.
- W4284968098 cites W2561697517 @default.
- W4284968098 cites W2572893236 @default.
- W4284968098 cites W2588077932 @default.
- W4284968098 cites W2593400956 @default.
- W4284968098 cites W2734511810 @default.
- W4284968098 cites W2734540391 @default.
- W4284968098 cites W2738386007 @default.
- W4284968098 cites W2742730399 @default.
- W4284968098 cites W2760871577 @default.
- W4284968098 cites W2786514708 @default.
- W4284968098 cites W2794015613 @default.
- W4284968098 cites W2798068251 @default.
- W4284968098 cites W2806199240 @default.
- W4284968098 cites W2904082638 @default.
- W4284968098 cites W2913985590 @default.
- W4284968098 cites W2952470997 @default.
- W4284968098 cites W2964649387 @default.
- W4284968098 cites W2982147188 @default.
- W4284968098 cites W2994551450 @default.
- W4284968098 cites W2999004616 @default.
- W4284968098 cites W3010846415 @default.
- W4284968098 cites W3097679100 @default.
- W4284968098 cites W3116795805 @default.
- W4284968098 cites W3180370962 @default.
- W4284968098 cites W3208691473 @default.
- W4284968098 cites W4200075765 @default.
- W4284968098 cites W4211135382 @default.
- W4284968098 doi "https://doi.org/10.1038/s41467-022-31751-0" @default.
- W4284968098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35810181" @default.
- W4284968098 hasPublicationYear "2022" @default.
- W4284968098 type Work @default.
- W4284968098 citedByCount "10" @default.
- W4284968098 countsByYear W42849680982022 @default.
- W4284968098 countsByYear W42849680982023 @default.
- W4284968098 crossrefType "journal-article" @default.
- W4284968098 hasAuthorship W4284968098A5010350753 @default.
- W4284968098 hasAuthorship W4284968098A5012138915 @default.
- W4284968098 hasAuthorship W4284968098A5019122793 @default.
- W4284968098 hasAuthorship W4284968098A5024662281 @default.
- W4284968098 hasAuthorship W4284968098A5030976623 @default.
- W4284968098 hasAuthorship W4284968098A5031897845 @default.
- W4284968098 hasAuthorship W4284968098A5048157560 @default.
- W4284968098 hasAuthorship W4284968098A5050664289 @default.
- W4284968098 hasAuthorship W4284968098A5052504607 @default.