Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284971208> ?p ?o ?g. }
- W4284971208 endingPage "1970" @default.
- W4284971208 startingPage "1950" @default.
- W4284971208 abstract "Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neurodegeneration. The ideal MS therapy would both specifically inhibit the underlying autoimmune response and promote repair/regeneration of myelin as well as maintenance of axonal integrity. Currently approved MS therapies consist of non-specific immunosuppressive molecules/antibodies which block activation or CNS homing of autoreactive T cells, but there are no approved therapies for stimulation of remyelination nor maintenance of axonal integrity. In an effort to repurpose an FDA-approved medication for myelin repair, we chose to examine the effectiveness of digoxin, a cardiac glycoside (Na+ /K+ ATPase inhibitor), originally identified as pro-myelinating in an in vitro screen. We found that digoxin regulated multiple genes in oligodendrocyte progenitor cells (OPCs) essential for oligodendrocyte (OL) differentiation in vitro, promoted OL differentiation both in vitro and in vivo in female naïve C57BL/6J (B6) mice, and stimulated recovery of myelinated axons in B6 mice following demyelination in the corpus callosum induced by cuprizone and spinal cord demyelination induced by lysophosphatidylcholine (LPC), respectively. More relevant to treatment of MS, we show that digoxin treatment of mice with established MOG35-55 -induced Th1/Th17-mediated chronic EAE combined with tolerance induced by the i.v. infusion of biodegradable poly(lactide-co-glycolide) nanoparticles coupled with MOG35-55 (PLG-MOG35-55 ) completely ameliorated clinical disease symptoms and stimulated recovery of OL lineage cell numbers. These findings provide critical pre-clinical evidence supporting future clinical trials of myelin-specific tolerance with myelin repair/regeneration drugs, such as digoxin, in MS patients." @default.
- W4284971208 created "2022-07-10" @default.
- W4284971208 creator A5002687023 @default.
- W4284971208 creator A5009178264 @default.
- W4284971208 creator A5018979130 @default.
- W4284971208 creator A5030332501 @default.
- W4284971208 creator A5032588542 @default.
- W4284971208 creator A5033876610 @default.
- W4284971208 creator A5035807747 @default.
- W4284971208 creator A5054722076 @default.
- W4284971208 creator A5065458574 @default.
- W4284971208 creator A5070856188 @default.
- W4284971208 creator A5071339945 @default.
- W4284971208 creator A5071934031 @default.
- W4284971208 creator A5079083947 @default.
- W4284971208 creator A5082808793 @default.
- W4284971208 creator A5084798371 @default.
- W4284971208 creator A5091128238 @default.
- W4284971208 creator A5091795035 @default.
- W4284971208 date "2022-07-09" @default.
- W4284971208 modified "2023-10-14" @default.
- W4284971208 title "Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in <scp>chemically‐induced</scp> and <scp>immune‐mediated</scp> mouse models of multiple sclerosis" @default.
- W4284971208 cites W1558288119 @default.
- W4284971208 cites W1560020441 @default.
- W4284971208 cites W1588408616 @default.
- W4284971208 cites W1754164368 @default.
- W4284971208 cites W1938046568 @default.
- W4284971208 cites W1964416005 @default.
- W4284971208 cites W1965942744 @default.
- W4284971208 cites W1976573815 @default.
- W4284971208 cites W1978684572 @default.
- W4284971208 cites W1978880986 @default.
- W4284971208 cites W1991883207 @default.
- W4284971208 cites W1992692157 @default.
- W4284971208 cites W2007461479 @default.
- W4284971208 cites W2011331227 @default.
- W4284971208 cites W2024724616 @default.
- W4284971208 cites W2034107216 @default.
- W4284971208 cites W2038392123 @default.
- W4284971208 cites W2048714464 @default.
- W4284971208 cites W2056677926 @default.
- W4284971208 cites W2078482008 @default.
- W4284971208 cites W2080607698 @default.
- W4284971208 cites W2085412596 @default.
- W4284971208 cites W2086547450 @default.
- W4284971208 cites W2095556311 @default.
- W4284971208 cites W2101483162 @default.
- W4284971208 cites W2108244474 @default.
- W4284971208 cites W2134526812 @default.
- W4284971208 cites W2140761981 @default.
- W4284971208 cites W2144540270 @default.
- W4284971208 cites W2155384604 @default.
- W4284971208 cites W2169256396 @default.
- W4284971208 cites W2169456326 @default.
- W4284971208 cites W2179438025 @default.
- W4284971208 cites W2251340927 @default.
- W4284971208 cites W2324016220 @default.
- W4284971208 cites W2338589974 @default.
- W4284971208 cites W2340461551 @default.
- W4284971208 cites W2344522662 @default.
- W4284971208 cites W2401980478 @default.
- W4284971208 cites W2432815617 @default.
- W4284971208 cites W2527704261 @default.
- W4284971208 cites W2572710398 @default.
- W4284971208 cites W2607023284 @default.
- W4284971208 cites W2743628961 @default.
- W4284971208 cites W2751637000 @default.
- W4284971208 cites W2775438937 @default.
- W4284971208 cites W2888671646 @default.
- W4284971208 cites W2897020726 @default.
- W4284971208 cites W2897587086 @default.
- W4284971208 cites W2913351110 @default.
- W4284971208 cites W2928665623 @default.
- W4284971208 cites W2964281414 @default.
- W4284971208 cites W2970272608 @default.
- W4284971208 cites W2997000088 @default.
- W4284971208 cites W3004735824 @default.
- W4284971208 cites W3004892697 @default.
- W4284971208 cites W3015197613 @default.
- W4284971208 cites W3092863788 @default.
- W4284971208 cites W3095773178 @default.
- W4284971208 cites W3136361932 @default.
- W4284971208 cites W4284971208 @default.
- W4284971208 doi "https://doi.org/10.1002/glia.24231" @default.
- W4284971208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35809238" @default.
- W4284971208 hasPublicationYear "2022" @default.
- W4284971208 type Work @default.
- W4284971208 citedByCount "5" @default.
- W4284971208 countsByYear W42849712082022 @default.
- W4284971208 countsByYear W42849712082023 @default.
- W4284971208 crossrefType "journal-article" @default.
- W4284971208 hasAuthorship W4284971208A5002687023 @default.
- W4284971208 hasAuthorship W4284971208A5009178264 @default.
- W4284971208 hasAuthorship W4284971208A5018979130 @default.
- W4284971208 hasAuthorship W4284971208A5030332501 @default.
- W4284971208 hasAuthorship W4284971208A5032588542 @default.
- W4284971208 hasAuthorship W4284971208A5033876610 @default.
- W4284971208 hasAuthorship W4284971208A5035807747 @default.