FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284972685> ?p ?o ?g. }

• W4284972685 endingPage "e09886" @default.
• W4284972685 startingPage "e09886" @default.
• W4284972685 abstract "An in vitro assay on Sigmoidin A from Erythrina abyssinica stem bark revealed its potency to inhibit pancreatic lipase. However, studies indicate activity of extract bioactive compounds in combination far exceed the favorable effects of each individual compound due to synergy and additive effects. In this study, we provide information on the effect of E. abyssinica stem bark extract in Drosophila melanogaster. The objective of the study was to determine the safety and effects of E. abyssinica stem bark extract on fly survival, body weight, triglycerides, sterol, total protein, and catalase activity of obese male D. melanogaster.Obesity was induced by exposing D. melanogaster white mutant w1118 to coconut food for two weeks. Groups 1-3 were fed on coconut food + fenofibrate at 25 mM, 50 mM, and 75 mM. Groups 4-6 were fed on coconut food + E. abyssinica stem bark extract at concentrations of 2.5 g/ml, 5.0 g/ml, and 7.5 g/ml. The positive control was exposed to only coconut food while the negative control was on regular food. Fly survival observations were done for 15 days, while acute and chronic effects were done at 30 min and after 48 h respectively following treatment. Body mass, negative geotaxis, reducing power of the extract, triglycerides (TG/TP), sterol, total protein levels, and catalase activity were measured after 10 days of exposure to the experimental diets.Fly survival changes were observed after 10 days and E. abyssinica stem bark extract had the strongest reducing power at 7.5 g/ml extract concentration. E. abyssinica stem bark extract reduced body mass, triglyceride levels (TG/TP), sterol levels, and modulated catalase activity at 7.5 g/ml extract concentration. Though the standard drug fenofibrate had the highest fat accumulation reduction potential, the extract at 7.5 g/ml was much safer in reducing fat accumulation in obese male D. melanogaster than other concentration used.Antioxidants in E. abyssinica stem bark extract are responsible for the observed anti-obesity activity." @default.
• W4284972685 created "2022-07-10" @default.
• W4284972685 creator A5013035596 @default.
• W4284972685 creator A5034096030 @default.
• W4284972685 creator A5035389439 @default.
• W4284972685 creator A5046078768 @default.
• W4284972685 creator A5048406864 @default.
• W4284972685 date "2022-07-01" @default.
• W4284972685 modified "2023-09-26" @default.
• W4284972685 title "Anti-obesity effects of Erythrina abyssinica stem bark extract in flies exposed to a high fat diet" @default.
• W4284972685 cites W1485927957 @default.
• W4284972685 cites W1495777555 @default.
• W4284972685 cites W1504250785 @default.
• W4284972685 cites W1679518225 @default.
• W4284972685 cites W1968727156 @default.
• W4284972685 cites W1976835212 @default.
• W4284972685 cites W2034078958 @default.
• W4284972685 cites W2049458262 @default.
• W4284972685 cites W2054226397 @default.
• W4284972685 cites W2061881187 @default.
• W4284972685 cites W2065717078 @default.
• W4284972685 cites W2070565046 @default.
• W4284972685 cites W2074405169 @default.
• W4284972685 cites W2075687762 @default.
• W4284972685 cites W2082904074 @default.
• W4284972685 cites W2093751113 @default.
• W4284972685 cites W2097229478 @default.
• W4284972685 cites W2107523209 @default.
• W4284972685 cites W2116553305 @default.
• W4284972685 cites W2119717666 @default.
• W4284972685 cites W2146725322 @default.
• W4284972685 cites W2150336670 @default.
• W4284972685 cites W2157593688 @default.
• W4284972685 cites W2170127298 @default.
• W4284972685 cites W2268374450 @default.
• W4284972685 cites W2321273235 @default.
• W4284972685 cites W2480327844 @default.
• W4284972685 cites W2532850922 @default.
• W4284972685 cites W2598290314 @default.
• W4284972685 cites W2608036712 @default.
• W4284972685 cites W2739053183 @default.
• W4284972685 cites W2897030573 @default.
• W4284972685 cites W2948008470 @default.
• W4284972685 cites W2951235614 @default.
• W4284972685 cites W88937860 @default.
• W4284972685 doi "https://doi.org/10.1016/j.heliyon.2022.e09886" @default.
• W4284972685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35847607" @default.
• W4284972685 hasPublicationYear "2022" @default.
• W4284972685 type Work @default.
• W4284972685 citedByCount "1" @default.
• W4284972685 countsByYear W42849726852023 @default.
• W4284972685 crossrefType "journal-article" @default.
• W4284972685 hasAuthorship W4284972685A5013035596 @default.
• W4284972685 hasAuthorship W4284972685A5034096030 @default.
• W4284972685 hasAuthorship W4284972685A5035389439 @default.
• W4284972685 hasAuthorship W4284972685A5046078768 @default.
• W4284972685 hasAuthorship W4284972685A5048406864 @default.
• W4284972685 hasBestOaLocation W42849726851 @default.
• W4284972685 hasConcept C133446333 @default.
• W4284972685 hasConcept C185592680 @default.
• W4284972685 hasConcept C18903297 @default.
• W4284972685 hasConcept C2778004101 @default.
• W4284972685 hasConcept C2778979269 @default.
• W4284972685 hasConcept C31903555 @default.
• W4284972685 hasConcept C55493867 @default.
• W4284972685 hasConcept C556039675 @default.
• W4284972685 hasConcept C59822182 @default.
• W4284972685 hasConcept C71924100 @default.
• W4284972685 hasConcept C86803240 @default.
• W4284972685 hasConceptScore W4284972685C133446333 @default.
• W4284972685 hasConceptScore W4284972685C185592680 @default.
• W4284972685 hasConceptScore W4284972685C18903297 @default.
• W4284972685 hasConceptScore W4284972685C2778004101 @default.
• W4284972685 hasConceptScore W4284972685C2778979269 @default.
• W4284972685 hasConceptScore W4284972685C31903555 @default.
• W4284972685 hasConceptScore W4284972685C55493867 @default.
• W4284972685 hasConceptScore W4284972685C556039675 @default.
• W4284972685 hasConceptScore W4284972685C59822182 @default.
• W4284972685 hasConceptScore W4284972685C71924100 @default.
• W4284972685 hasConceptScore W4284972685C86803240 @default.
• W4284972685 hasIssue "7" @default.
• W4284972685 hasLocation W42849726851 @default.
• W4284972685 hasLocation W42849726852 @default.
• W4284972685 hasLocation W42849726853 @default.
• W4284972685 hasOpenAccess W4284972685 @default.
• W4284972685 hasPrimaryLocation W42849726851 @default.
• W4284972685 hasRelatedWork W2023271816 @default.
• W4284972685 hasRelatedWork W2027989916 @default.
• W4284972685 hasRelatedWork W2047134548 @default.
• W4284972685 hasRelatedWork W2085710752 @default.
• W4284972685 hasRelatedWork W2119976708 @default.
• W4284972685 hasRelatedWork W2157796563 @default.
• W4284972685 hasRelatedWork W2981713487 @default.
• W4284972685 hasRelatedWork W3042563890 @default.
• W4284972685 hasRelatedWork W3215139134 @default.
• W4284972685 hasRelatedWork W770724554 @default.
• W4284972685 hasVolume "8" @default.
• W4284972685 isParatext "false" @default.

• next