Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284974498> ?p ?o ?g. }
- W4284974498 endingPage "2330" @default.
- W4284974498 startingPage "2313" @default.
- W4284974498 abstract "In the setting of obesity and insulin resistance, glycemia is controlled in part by β-cell compensation and subsequent hyperinsulinemia. Weight loss improves glycemia and decreases hyperinsulinemia, whereas weight cycling worsens glycemic control. The mechanisms responsible for weight cycling–induced deterioration in glucose homeostasis are poorly understood. Thus, we aimed to pinpoint the main regulatory junctions at which weight cycling alters glucose homeostasis in mice. Using in vivo and ex vivo procedures we show that despite having worsened glucose tolerance, weight-cycled mice do not manifest impaired whole-body insulin action. Instead, weight cycling reduces insulin secretory capacity in vivo during clamped hyperglycemia and ex vivo in perifused islets. Islets from weight-cycled mice have reduced expression of factors essential for β-cell function (Mafa, Pdx1, Nkx6.1, Ucn3) and lower islet insulin content, compared with those from obese mice, suggesting inadequate transcriptional and posttranscriptional response to repeated nutrient overload. Collectively, these data support a model in which pancreatic plasticity is challenged in the face of large fluctuations in body weight resulting in a mismatch between glycemia and insulin secretion in mice." @default.
- W4284974498 created "2022-07-10" @default.
- W4284974498 creator A5047101656 @default.
- W4284974498 creator A5049785220 @default.
- W4284974498 creator A5051703391 @default.
- W4284974498 creator A5055009761 @default.
- W4284974498 creator A5071761243 @default.
- W4284974498 creator A5082971980 @default.
- W4284974498 creator A5087864198 @default.
- W4284974498 date "2022-07-08" @default.
- W4284974498 modified "2023-10-16" @default.
- W4284974498 title "Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity" @default.
- W4284974498 cites W1598254642 @default.
- W4284974498 cites W1974894120 @default.
- W4284974498 cites W1978311815 @default.
- W4284974498 cites W1985592156 @default.
- W4284974498 cites W1990421662 @default.
- W4284974498 cites W2003011873 @default.
- W4284974498 cites W2005518541 @default.
- W4284974498 cites W2010290591 @default.
- W4284974498 cites W2015143141 @default.
- W4284974498 cites W2021208867 @default.
- W4284974498 cites W2029217156 @default.
- W4284974498 cites W2035168927 @default.
- W4284974498 cites W2037149533 @default.
- W4284974498 cites W2042381753 @default.
- W4284974498 cites W2044481780 @default.
- W4284974498 cites W2044927096 @default.
- W4284974498 cites W2048226041 @default.
- W4284974498 cites W2052102985 @default.
- W4284974498 cites W2054932272 @default.
- W4284974498 cites W2060392241 @default.
- W4284974498 cites W2075355954 @default.
- W4284974498 cites W2077963393 @default.
- W4284974498 cites W2084278139 @default.
- W4284974498 cites W2085258549 @default.
- W4284974498 cites W2097784879 @default.
- W4284974498 cites W2108210081 @default.
- W4284974498 cites W2109728760 @default.
- W4284974498 cites W2111886083 @default.
- W4284974498 cites W2114104545 @default.
- W4284974498 cites W2117574263 @default.
- W4284974498 cites W2125139348 @default.
- W4284974498 cites W2127314787 @default.
- W4284974498 cites W2140993611 @default.
- W4284974498 cites W2145498419 @default.
- W4284974498 cites W2152956628 @default.
- W4284974498 cites W2156044622 @default.
- W4284974498 cites W2156097550 @default.
- W4284974498 cites W2158399663 @default.
- W4284974498 cites W2159201861 @default.
- W4284974498 cites W2164256676 @default.
- W4284974498 cites W2167607159 @default.
- W4284974498 cites W2168413939 @default.
- W4284974498 cites W2168593494 @default.
- W4284974498 cites W2283576174 @default.
- W4284974498 cites W2335958328 @default.
- W4284974498 cites W2570569124 @default.
- W4284974498 cites W2592811885 @default.
- W4284974498 cites W2605289354 @default.
- W4284974498 cites W2735294429 @default.
- W4284974498 cites W2735941788 @default.
- W4284974498 cites W2767672289 @default.
- W4284974498 cites W2796621520 @default.
- W4284974498 cites W2810201367 @default.
- W4284974498 cites W2902322680 @default.
- W4284974498 cites W2951912016 @default.
- W4284974498 cites W2988213118 @default.
- W4284974498 cites W3081067659 @default.
- W4284974498 cites W3174565508 @default.
- W4284974498 cites W3185897897 @default.
- W4284974498 cites W4205817659 @default.
- W4284974498 cites W4230095346 @default.
- W4284974498 cites W4281552824 @default.
- W4284974498 cites W2598436589 @default.
- W4284974498 doi "https://doi.org/10.2337/db22-0161" @default.
- W4284974498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35802127" @default.
- W4284974498 hasPublicationYear "2022" @default.
- W4284974498 type Work @default.
- W4284974498 citedByCount "5" @default.
- W4284974498 countsByYear W42849744982022 @default.
- W4284974498 countsByYear W42849744982023 @default.
- W4284974498 crossrefType "journal-article" @default.
- W4284974498 hasAuthorship W4284974498A5047101656 @default.
- W4284974498 hasAuthorship W4284974498A5049785220 @default.
- W4284974498 hasAuthorship W4284974498A5051703391 @default.
- W4284974498 hasAuthorship W4284974498A5055009761 @default.
- W4284974498 hasAuthorship W4284974498A5071761243 @default.
- W4284974498 hasAuthorship W4284974498A5082971980 @default.
- W4284974498 hasAuthorship W4284974498A5087864198 @default.
- W4284974498 hasBestOaLocation W42849744981 @default.
- W4284974498 hasConcept C126322002 @default.
- W4284974498 hasConcept C134018914 @default.
- W4284974498 hasConcept C144855686 @default.
- W4284974498 hasConcept C150903083 @default.
- W4284974498 hasConcept C165220095 @default.
- W4284974498 hasConcept C207001950 @default.
- W4284974498 hasConcept C26291073 @default.