Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284975890> ?p ?o ?g. }
- W4284975890 abstract "Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disorder. Progerin also accumulates during physiological aging. Here, we demonstrate that impaired insulin-like growth factor 1 receptor (IGF-1R)/Akt signaling pathway results in severe growth retardation and premature aging in Zmpste24-/- mice, a mouse model of progeria. Mechanistically, progerin mislocalizes outside of the nucleus, interacts with the IGF-1R, and down-regulates its expression, leading to inhibited mitochondrial respiration, retarded cell growth, and accelerated cellular senescence. Pharmacological treatment with the PTEN (phosphatase and tensin homolog deleted on chromosome 10) inhibitor bpV (HOpic) increases Akt activity and improves multiple abnormalities in Zmpste24-deficient mice. These findings provide previously unidentified insights into the role of progerin in regulating the IGF-1R/Akt signaling in HGPS and might be useful for treating LMNA-associated progeroid disorders." @default.
- W4284975890 created "2022-07-10" @default.
- W4284975890 creator A5001731489 @default.
- W4284975890 creator A5002285198 @default.
- W4284975890 creator A5004918492 @default.
- W4284975890 creator A5005986905 @default.
- W4284975890 creator A5011179194 @default.
- W4284975890 creator A5015759381 @default.
- W4284975890 creator A5019949546 @default.
- W4284975890 creator A5021093366 @default.
- W4284975890 creator A5023852372 @default.
- W4284975890 creator A5026958198 @default.
- W4284975890 creator A5034434808 @default.
- W4284975890 creator A5036110163 @default.
- W4284975890 creator A5036770398 @default.
- W4284975890 creator A5040626069 @default.
- W4284975890 creator A5043443393 @default.
- W4284975890 creator A5045651065 @default.
- W4284975890 creator A5047656136 @default.
- W4284975890 creator A5051764626 @default.
- W4284975890 creator A5055472399 @default.
- W4284975890 creator A5064293879 @default.
- W4284975890 creator A5065900474 @default.
- W4284975890 creator A5072198686 @default.
- W4284975890 creator A5073707720 @default.
- W4284975890 creator A5076126968 @default.
- W4284975890 creator A5076251438 @default.
- W4284975890 creator A5080268249 @default.
- W4284975890 creator A5086559201 @default.
- W4284975890 creator A5088481321 @default.
- W4284975890 date "2022-07-08" @default.
- W4284975890 modified "2023-10-14" @default.
- W4284975890 title "Progerin modulates the IGF-1R/Akt signaling involved in aging" @default.
- W4284975890 cites W1589421810 @default.
- W4284975890 cites W1726025741 @default.
- W4284975890 cites W1964551999 @default.
- W4284975890 cites W1969854194 @default.
- W4284975890 cites W1985425785 @default.
- W4284975890 cites W1995466259 @default.
- W4284975890 cites W2002569327 @default.
- W4284975890 cites W2009306385 @default.
- W4284975890 cites W2009667193 @default.
- W4284975890 cites W2011942547 @default.
- W4284975890 cites W2021128415 @default.
- W4284975890 cites W2021687666 @default.
- W4284975890 cites W2036973053 @default.
- W4284975890 cites W2040143421 @default.
- W4284975890 cites W2053206914 @default.
- W4284975890 cites W2059281747 @default.
- W4284975890 cites W2059690468 @default.
- W4284975890 cites W2061331409 @default.
- W4284975890 cites W2067751798 @default.
- W4284975890 cites W2072810104 @default.
- W4284975890 cites W2073460054 @default.
- W4284975890 cites W2079335891 @default.
- W4284975890 cites W2101410699 @default.
- W4284975890 cites W2104908670 @default.
- W4284975890 cites W2105685115 @default.
- W4284975890 cites W2111175126 @default.
- W4284975890 cites W2111752734 @default.
- W4284975890 cites W2111819985 @default.
- W4284975890 cites W2119795320 @default.
- W4284975890 cites W2122132943 @default.
- W4284975890 cites W2126525177 @default.
- W4284975890 cites W2131840335 @default.
- W4284975890 cites W2141334538 @default.
- W4284975890 cites W2143185290 @default.
- W4284975890 cites W2145283260 @default.
- W4284975890 cites W2156077465 @default.
- W4284975890 cites W2172254982 @default.
- W4284975890 cites W2315987042 @default.
- W4284975890 cites W2921615125 @default.
- W4284975890 cites W3015565541 @default.
- W4284975890 cites W3023755251 @default.
- W4284975890 cites W3044536137 @default.
- W4284975890 cites W3152911680 @default.
- W4284975890 cites W3193877092 @default.
- W4284975890 doi "https://doi.org/10.1126/sciadv.abo0322" @default.
- W4284975890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35857466" @default.
- W4284975890 hasPublicationYear "2022" @default.
- W4284975890 type Work @default.
- W4284975890 citedByCount "4" @default.
- W4284975890 countsByYear W42849758902022 @default.
- W4284975890 countsByYear W42849758902023 @default.
- W4284975890 crossrefType "journal-article" @default.
- W4284975890 hasAuthorship W4284975890A5001731489 @default.
- W4284975890 hasAuthorship W4284975890A5002285198 @default.
- W4284975890 hasAuthorship W4284975890A5004918492 @default.
- W4284975890 hasAuthorship W4284975890A5005986905 @default.
- W4284975890 hasAuthorship W4284975890A5011179194 @default.
- W4284975890 hasAuthorship W4284975890A5015759381 @default.
- W4284975890 hasAuthorship W4284975890A5019949546 @default.
- W4284975890 hasAuthorship W4284975890A5021093366 @default.
- W4284975890 hasAuthorship W4284975890A5023852372 @default.
- W4284975890 hasAuthorship W4284975890A5026958198 @default.
- W4284975890 hasAuthorship W4284975890A5034434808 @default.
- W4284975890 hasAuthorship W4284975890A5036110163 @default.
- W4284975890 hasAuthorship W4284975890A5036770398 @default.
- W4284975890 hasAuthorship W4284975890A5040626069 @default.
- W4284975890 hasAuthorship W4284975890A5043443393 @default.