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- W4284976802 abstract "Talatisamine (1), isolated from an Aconitum species, is a C19-diterpenoid alkaloid that selectively inhibits K+ channel and exhibits an antiarrhythmic effect. The structure of 1 is quite unique, consisting of the intricately fused 6/7/5/6/6/5-membered hexacyclic ring system with five oxygen functionalities and twelve contiguous stereocenters. Both the intriguing structure and biological activities have attracted the attention of organic chemists. In this short review, recent total syntheses of 1 by Inoue and Reisman groups are discussed with focusing on synthetic strategy." @default.
- W4284976802 created "2022-07-10" @default.
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- W4284976802 date "2022-07-01" @default.
- W4284976802 modified "2023-10-14" @default.
- W4284976802 title "Total Synthesis of C19 Diterpene Alkaloid Talatisamine" @default.
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- W4284976802 doi "https://doi.org/10.5059/yukigoseikyokaishi.80.691" @default.
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