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- W4284991672 abstract "Platinum resistance is one of the major concerns in ovarian cancer treatment. Recent evidence shows the critical role of epithelial–mesenchymal transition (EMT) in this resistance. Epithelial-like ovarian cancer cells show decreased sensitivity to cisplatin after cisplatin treatment. Our study prospected the association between epithelial phenotype and response to cisplatin in ovarian cancer. Microarray dataset GSE47856 was acquired from the GEO database. After identifying differentially expressed genes (DEGs) between epithelial-like and mesenchymal-like cells, the module identification analysis was performed using weighted gene co-expression network analysis (WGCNA). The gene ontology (GO) and pathway analyses of the most considerable modules were performed. The protein–protein interaction network was also constructed. The hub genes were specified using Cytoscape plugins MCODE and cytoHubba, followed by the survival analysis and data validation. Finally, the co-expression of miRNA-lncRNA-TF with the hub genes was reconstructed. The co-expression network analysis suggests 20 modules relating to the Epithelial phenotype. The antiquewhite4, brown and darkmagenta modules are the most significant non-preserved modules in the Epithelial phenotype and contain the most differentially expressed genes. GO, and KEGG pathway enrichment analyses on these modules divulge that these genes were primarily enriched in the focal adhesion, DNA replication pathways and stress response processes. ROC curve and overall survival rate analysis show that the co-expression pattern of the brown module's hub genes could be a potential prognostic biomarker for ovarian cancer cisplatin resistance." @default.
- W4284991672 created "2022-07-11" @default.
- W4284991672 creator A5026809981 @default.
- W4284991672 creator A5080376646 @default.
- W4284991672 creator A5081190676 @default.
- W4284991672 date "2022-07-10" @default.
- W4284991672 modified "2023-09-28" @default.
- W4284991672 title "Construction of <scp>miRNA‐lncRNA‐mRNA</scp> co‐expression network affecting <scp>EMT‐</scp> mediated cisplatin resistance in ovarian cancer" @default.
- W4284991672 cites W1493801922 @default.
- W4284991672 cites W1628408467 @default.
- W4284991672 cites W1821897424 @default.
- W4284991672 cites W1964081206 @default.
- W4284991672 cites W1966051785 @default.
- W4284991672 cites W1966327575 @default.
- W4284991672 cites W1970265228 @default.
- W4284991672 cites W1976324983 @default.
- W4284991672 cites W1980684292 @default.
- W4284991672 cites W1983623971 @default.
- W4284991672 cites W1983991097 @default.
- W4284991672 cites W1986911605 @default.
- W4284991672 cites W1988141621 @default.
- W4284991672 cites W2005852730 @default.
- W4284991672 cites W2026324708 @default.
- W4284991672 cites W2027787548 @default.
- W4284991672 cites W2029922807 @default.
- W4284991672 cites W2035618305 @default.
- W4284991672 cites W2037233818 @default.
- W4284991672 cites W2038843789 @default.
- W4284991672 cites W2039358584 @default.
- W4284991672 cites W2047475076 @default.
- W4284991672 cites W2056984342 @default.
- W4284991672 cites W2057016495 @default.
- W4284991672 cites W2058073053 @default.
- W4284991672 cites W2058578736 @default.
- W4284991672 cites W2059768038 @default.
- W4284991672 cites W2060705109 @default.
- W4284991672 cites W2068854353 @default.
- W4284991672 cites W2069310363 @default.
- W4284991672 cites W2072245877 @default.
- W4284991672 cites W2074373608 @default.
- W4284991672 cites W2079360110 @default.
- W4284991672 cites W2079484912 @default.
- W4284991672 cites W2080900378 @default.
- W4284991672 cites W2081837126 @default.
- W4284991672 cites W2082969979 @default.
- W4284991672 cites W2084126321 @default.
- W4284991672 cites W2089468765 @default.
- W4284991672 cites W2090200270 @default.
- W4284991672 cites W2095927032 @default.
- W4284991672 cites W2101595088 @default.
- W4284991672 cites W2103912979 @default.
- W4284991672 cites W2124840632 @default.
- W4284991672 cites W2125566625 @default.
- W4284991672 cites W2127281537 @default.
- W4284991672 cites W2130177169 @default.
- W4284991672 cites W2136850043 @default.
- W4284991672 cites W2142807621 @default.
- W4284991672 cites W2145193102 @default.
- W4284991672 cites W2146512944 @default.
- W4284991672 cites W2150631512 @default.
- W4284991672 cites W2152625770 @default.
- W4284991672 cites W2154010498 @default.
- W4284991672 cites W2157756773 @default.
- W4284991672 cites W2158301110 @default.
- W4284991672 cites W2159515687 @default.
- W4284991672 cites W2159675211 @default.
- W4284991672 cites W2164023739 @default.
- W4284991672 cites W2169101662 @default.
- W4284991672 cites W2170989872 @default.
- W4284991672 cites W2188144501 @default.
- W4284991672 cites W2228586054 @default.
- W4284991672 cites W2235645467 @default.
- W4284991672 cites W2287472947 @default.
- W4284991672 cites W2303621525 @default.
- W4284991672 cites W2305551225 @default.
- W4284991672 cites W2342768228 @default.
- W4284991672 cites W2409480830 @default.
- W4284991672 cites W2414593708 @default.
- W4284991672 cites W2468395557 @default.
- W4284991672 cites W2550836710 @default.
- W4284991672 cites W2602663030 @default.
- W4284991672 cites W2611766550 @default.
- W4284991672 cites W2616770430 @default.
- W4284991672 cites W2618927519 @default.
- W4284991672 cites W2712639046 @default.
- W4284991672 cites W2753179860 @default.
- W4284991672 cites W2761824327 @default.
- W4284991672 cites W2768175011 @default.
- W4284991672 cites W2783392754 @default.
- W4284991672 cites W2788915030 @default.
- W4284991672 cites W2794283040 @default.
- W4284991672 cites W2807513517 @default.
- W4284991672 cites W2809168015 @default.
- W4284991672 cites W2885846020 @default.
- W4284991672 cites W2886702901 @default.
- W4284991672 cites W2889087072 @default.
- W4284991672 cites W2889873381 @default.
- W4284991672 cites W2900975497 @default.