FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284993381> ?p ?o ?g. }

• W4284993381 endingPage "5046" @default.
• W4284993381 startingPage "5046" @default.
• W4284993381 abstract "Aim . To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD). Material and methods . This retrospective cross-sectional study included 76 men aged 40 to 79 years. Patients were divided into following groups: main group — patients with CAD (58 [54;64] years, n=56) onset before the age of 55; control group — patients (62 [57;66] years, n=20) without CAD and obstructive CAD and peripheral arterial disease. Statins were taken by 51 (91%) and 9 (45%) patients in the main and control groups, respectively. In serum and plasma samples, lipid spectrum parameters and Lp(a) concentration were determined. Cellular phenotyping was performed by direct immunofluorescence in a culture of mononuclear leukocytes isolated from blood. To determine cytokines, cells were in vitro activated with inhibitor of intracellular transport of secretory proteins. Cell fluorescence was determined using flow cytometry. Results . Patients of both groups were comparable in age, body mass index, prevalence of hypertension and diabetes. Blood Lp(a) concentrations were higher in the CAD group than in the control group (49 [10;102] mg/dL vs 12 [4,3;32] mg/ dL, p<0,05). The content of INFγ-producing T-helpers 17 (Th17/1) was also higher in the CAD group (19 [15;24] vs 13 [11;22], % of Th17, p=0,05). Logistic regression revealed that elevated Lp(a) levels (≥30 mg/dL) and relative amounts of Th17/1 (>14% of Th17) independently of each other, atherogenic lipoprotein cholesterol levels, classical risk factors, and statin use were associated with premature CAD in the general group of patients with odds ratio (OR) of 4,6 (95% confidence interval (CI), 1,1-20,2) and 10,9 (2,1-56,7), p<0,05, respectively. The combination of Lp(a) >30 mg/dl and Th17/1 over 14% significantly increased the risk of premature CAD (OR, 28,0, 95% CI, 4,31-181,75, p=0,0005). Conclusion . We have shown for the first time that an increased Lp(a) concentration with an increased Th17/1 content is associated with the premature CAD in men." @default.
• W4284993381 created "2022-07-11" @default.
• W4284993381 creator A5008055885 @default.
• W4284993381 creator A5024982865 @default.
• W4284993381 creator A5039482436 @default.
• W4284993381 creator A5048011479 @default.
• W4284993381 creator A5059147991 @default.
• W4284993381 creator A5077205458 @default.
• W4284993381 creator A5078948501 @default.
• W4284993381 date "2022-05-06" @default.
• W4284993381 modified "2023-09-26" @default.
• W4284993381 title "Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease" @default.
• W4284993381 cites W2009131397 @default.
• W4284993381 cites W2191026300 @default.
• W4284993381 cites W2531191296 @default.
• W4284993381 cites W2796223745 @default.
• W4284993381 cites W2951164752 @default.
• W4284993381 cites W2953897495 @default.
• W4284993381 cites W2970862045 @default.
• W4284993381 cites W3010741823 @default.
• W4284993381 cites W3014968485 @default.
• W4284993381 cites W3021869046 @default.
• W4284993381 cites W3048887029 @default.
• W4284993381 cites W3172100528 @default.
• W4284993381 cites W3172287051 @default.
• W4284993381 cites W4206326061 @default.
• W4284993381 cites W4226321666 @default.
• W4284993381 doi "https://doi.org/10.15829/1560-4071-2022-5046" @default.
• W4284993381 hasPublicationYear "2022" @default.
• W4284993381 type Work @default.
• W4284993381 citedByCount "0" @default.
• W4284993381 crossrefType "journal-article" @default.
• W4284993381 hasAuthorship W4284993381A5008055885 @default.
• W4284993381 hasAuthorship W4284993381A5024982865 @default.
• W4284993381 hasAuthorship W4284993381A5039482436 @default.
• W4284993381 hasAuthorship W4284993381A5048011479 @default.
• W4284993381 hasAuthorship W4284993381A5059147991 @default.
• W4284993381 hasAuthorship W4284993381A5077205458 @default.
• W4284993381 hasAuthorship W4284993381A5078948501 @default.
• W4284993381 hasBestOaLocation W42849933811 @default.
• W4284993381 hasConcept C126322002 @default.
• W4284993381 hasConcept C134018914 @default.
• W4284993381 hasConcept C137061746 @default.
• W4284993381 hasConcept C151956035 @default.
• W4284993381 hasConcept C185592680 @default.
• W4284993381 hasConcept C202751555 @default.
• W4284993381 hasConcept C203014093 @default.
• W4284993381 hasConcept C2778163477 @default.
• W4284993381 hasConcept C2778213512 @default.
• W4284993381 hasConcept C2778270857 @default.
• W4284993381 hasConcept C2780072125 @default.
• W4284993381 hasConcept C2780221984 @default.
• W4284993381 hasConcept C553184892 @default.
• W4284993381 hasConcept C55493867 @default.
• W4284993381 hasConcept C555293320 @default.
• W4284993381 hasConcept C71924100 @default.
• W4284993381 hasConcept C90924648 @default.
• W4284993381 hasConceptScore W4284993381C126322002 @default.
• W4284993381 hasConceptScore W4284993381C134018914 @default.
• W4284993381 hasConceptScore W4284993381C137061746 @default.
• W4284993381 hasConceptScore W4284993381C151956035 @default.
• W4284993381 hasConceptScore W4284993381C185592680 @default.
• W4284993381 hasConceptScore W4284993381C202751555 @default.
• W4284993381 hasConceptScore W4284993381C203014093 @default.
• W4284993381 hasConceptScore W4284993381C2778163477 @default.
• W4284993381 hasConceptScore W4284993381C2778213512 @default.
• W4284993381 hasConceptScore W4284993381C2778270857 @default.
• W4284993381 hasConceptScore W4284993381C2780072125 @default.
• W4284993381 hasConceptScore W4284993381C2780221984 @default.
• W4284993381 hasConceptScore W4284993381C553184892 @default.
• W4284993381 hasConceptScore W4284993381C55493867 @default.
• W4284993381 hasConceptScore W4284993381C555293320 @default.
• W4284993381 hasConceptScore W4284993381C71924100 @default.
• W4284993381 hasConceptScore W4284993381C90924648 @default.
• W4284993381 hasIssue "6" @default.
• W4284993381 hasLocation W42849933811 @default.
• W4284993381 hasLocation W42849933812 @default.
• W4284993381 hasOpenAccess W4284993381 @default.
• W4284993381 hasPrimaryLocation W42849933811 @default.
• W4284993381 hasRelatedWork W1976602105 @default.
• W4284993381 hasRelatedWork W2025648868 @default.
• W4284993381 hasRelatedWork W2028375480 @default.
• W4284993381 hasRelatedWork W2035331946 @default.
• W4284993381 hasRelatedWork W2040191035 @default.
• W4284993381 hasRelatedWork W2118738696 @default.
• W4284993381 hasRelatedWork W2147702047 @default.
• W4284993381 hasRelatedWork W2157155183 @default.
• W4284993381 hasRelatedWork W2413861530 @default.
• W4284993381 hasRelatedWork W4244653511 @default.
• W4284993381 hasVolume "27" @default.
• W4284993381 isParatext "false" @default.
• W4284993381 isRetracted "false" @default.
• W4284993381 workType "article" @default.