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- W4284993995 abstract "A hemolytic transfusion reaction (HTR) is the accelerated clearance or destruction of red blood cells associated with a transfusion event. Causes of HTRs and differential diagnoses are summarized. The pathophysiology of hemolytic transfusion reactions is dependent on the type of antigens and antibodies involved, as well as host factors. The complement system is composed of about 50 serum and membrane proteins with tightly regulated proteolytic activation cascades that culminate in the production of effector molecules with multiple biological functions. The role of macrophages in hemolysis has been studied since the 1950s. Bystander hemolysis has been defined as the destruction of antigen-negative red cells during immune hemolysis; it plays an important role in delayed HTRs in sickle cell disease and is a hallmark of hyperhemolysis. An acute HTR is considered a medical emergency. Many core blood bank procedures are ultimately directed toward the prevention of HTRs." @default.
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- W4284993995 date "2022-07-10" @default.
- W4284993995 modified "2023-09-24" @default.
- W4284993995 title "Hemolytic transfusion reactions" @default.
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- W4284993995 doi "https://doi.org/10.1002/9781119719809.ch47" @default.
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