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- W4284994124 abstract "Abstract Widespread shutoff of host gene expression through RNA degradation is an advantageous way for many viruses to block antiviral responses. However, viruses still need to maintain expression of their own genes and host genes necessary for replication. The influenza A virus host shutoff endoribonuclease PA-X solves this problem by sparing viral mRNAs and some host RNAs. To understand how PA-X distinguishes between RNAs, we characterized PA-X cut sites transcriptome-wide. This analysis shows that PA-Xs from multiple influenza strains cleave RNAs at GCUG tetramers in hairpin loops. Importantly, GCUG tetramers are enriched in the human but not the influenza transcriptome. Moreover, optimal PA-X cut sites inserted in the influenza A virus genome are quickly selected against during viral replication. This finding suggests that PA-X evolved these cleavage characteristics to target host but not viral mRNAs, in a manner reminiscent of cellular self vs. non-self discrimination." @default.
- W4284994124 created "2022-07-11" @default.
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- W4284994124 date "2022-07-09" @default.
- W4284994124 modified "2023-10-01" @default.
- W4284994124 title "The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs" @default.
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- W4284994124 doi "https://doi.org/10.1101/2022.07.08.499385" @default.
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