Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285008010> ?p ?o ?g. }
- W4285008010 abstract "Decabromodiphenyl ethane (DBDPE) is a novel retardant. DBDPE is used in various flammable consumer products such as electronics, building materials, textiles, and children's toys. The presence of DBDPE in humans makes it extremely urgent to assess the health effects of DBDPE exposure. Here, we used female mice as an animal model to investigate the effects of DBDPE on embryonic development and offspring health. The results showed that 50 μg/kg bw/day of DBDPE exposure did not affect spindle rotation in oocytes after fertilization, but led to a decrease of pronuclei (PN) in zygotes. Further investigation found that DBDPE interferes with the self-assembly of F-actin in PN, resulting in PN reduction, DNA damage, and reduced expression of zygotic genome activating genes, and finally leading to abnormal embryonic development. More importantly, we found that maternal DBDPE exposure did not affect the growth and development of the first generation of offspring (F1) mice, but resulted in behavioral defects in F1 mice. Female F1 mice from DBDPE-exposed mothers exhibited increased motor activity and deficits in social behavior. Both female and male F1 mice from DBDPE-exposed mothers exhibited cognitive memory impairment. These results suggest that DBDPE has developmental toxicity on embryos and has a cross-generational interference effect. It is suggested that people should pay attention to the reproductive toxicity of DBDPE. In addition, it also provides a reference for studying the origin of neurological diseases and indicates that adult diseases caused by environmental pollutants may have begun in the embryonic stage." @default.
- W4285008010 created "2022-07-12" @default.
- W4285008010 creator A5012526039 @default.
- W4285008010 creator A5013131341 @default.
- W4285008010 creator A5015833949 @default.
- W4285008010 creator A5034713347 @default.
- W4285008010 creator A5046210257 @default.
- W4285008010 creator A5047383713 @default.
- W4285008010 creator A5065109723 @default.
- W4285008010 creator A5071115431 @default.
- W4285008010 creator A5076683391 @default.
- W4285008010 date "2022-07-11" @default.
- W4285008010 modified "2023-10-01" @default.
- W4285008010 title "Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F‐actin in zygotes and leads to cognitive and social disorders in offspring mice" @default.
- W4285008010 cites W1481250329 @default.
- W4285008010 cites W1500301819 @default.
- W4285008010 cites W1579202197 @default.
- W4285008010 cites W1753061139 @default.
- W4285008010 cites W1923618315 @default.
- W4285008010 cites W1966091621 @default.
- W4285008010 cites W1977206884 @default.
- W4285008010 cites W1997235708 @default.
- W4285008010 cites W1997611686 @default.
- W4285008010 cites W2005808461 @default.
- W4285008010 cites W2014371439 @default.
- W4285008010 cites W2023883958 @default.
- W4285008010 cites W2033845019 @default.
- W4285008010 cites W2034923684 @default.
- W4285008010 cites W2039184346 @default.
- W4285008010 cites W2040414777 @default.
- W4285008010 cites W2044256182 @default.
- W4285008010 cites W2044690479 @default.
- W4285008010 cites W2053588982 @default.
- W4285008010 cites W2058036743 @default.
- W4285008010 cites W2068417529 @default.
- W4285008010 cites W2069334538 @default.
- W4285008010 cites W2070768548 @default.
- W4285008010 cites W2074536102 @default.
- W4285008010 cites W2074584228 @default.
- W4285008010 cites W2076994772 @default.
- W4285008010 cites W2102752109 @default.
- W4285008010 cites W2117249342 @default.
- W4285008010 cites W2135229679 @default.
- W4285008010 cites W2152754359 @default.
- W4285008010 cites W2154903663 @default.
- W4285008010 cites W2342014962 @default.
- W4285008010 cites W2509149139 @default.
- W4285008010 cites W2510409945 @default.
- W4285008010 cites W2544891225 @default.
- W4285008010 cites W2601508128 @default.
- W4285008010 cites W2736537627 @default.
- W4285008010 cites W2737597838 @default.
- W4285008010 cites W2768632776 @default.
- W4285008010 cites W2772129173 @default.
- W4285008010 cites W2791408347 @default.
- W4285008010 cites W2795438865 @default.
- W4285008010 cites W2808968889 @default.
- W4285008010 cites W2809439755 @default.
- W4285008010 cites W2891270204 @default.
- W4285008010 cites W2915466156 @default.
- W4285008010 cites W2922581887 @default.
- W4285008010 cites W2952528783 @default.
- W4285008010 cites W2980407404 @default.
- W4285008010 cites W2988728671 @default.
- W4285008010 cites W2990777904 @default.
- W4285008010 cites W2991205176 @default.
- W4285008010 cites W2993850258 @default.
- W4285008010 cites W2999657683 @default.
- W4285008010 cites W3011291325 @default.
- W4285008010 cites W3014436419 @default.
- W4285008010 cites W3018973994 @default.
- W4285008010 cites W3038851023 @default.
- W4285008010 cites W3042931248 @default.
- W4285008010 cites W3087066649 @default.
- W4285008010 cites W3088870768 @default.
- W4285008010 cites W3094373587 @default.
- W4285008010 cites W3110770812 @default.
- W4285008010 cites W3111149067 @default.
- W4285008010 cites W3137275148 @default.
- W4285008010 cites W4200324101 @default.
- W4285008010 doi "https://doi.org/10.1096/fj.202200586r" @default.
- W4285008010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35816173" @default.
- W4285008010 hasPublicationYear "2022" @default.
- W4285008010 type Work @default.
- W4285008010 citedByCount "5" @default.
- W4285008010 countsByYear W42850080102022 @default.
- W4285008010 countsByYear W42850080102023 @default.
- W4285008010 crossrefType "journal-article" @default.
- W4285008010 hasAuthorship W4285008010A5012526039 @default.
- W4285008010 hasAuthorship W4285008010A5013131341 @default.
- W4285008010 hasAuthorship W4285008010A5015833949 @default.
- W4285008010 hasAuthorship W4285008010A5034713347 @default.
- W4285008010 hasAuthorship W4285008010A5046210257 @default.
- W4285008010 hasAuthorship W4285008010A5047383713 @default.
- W4285008010 hasAuthorship W4285008010A5065109723 @default.
- W4285008010 hasAuthorship W4285008010A5071115431 @default.
- W4285008010 hasAuthorship W4285008010A5076683391 @default.
- W4285008010 hasConcept C104317684 @default.
- W4285008010 hasConcept C112672928 @default.
- W4285008010 hasConcept C145103041 @default.