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- W4285008675 abstract "Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known about its aetiology, risk factors, and disease progression. There are currently neither validated biomarkers for diagnostic screening nor specific medication for autism. Over the last two decades, there have been remarkable advances in genetics, with hundreds of genes identified and validated as being associated with a high risk for autism. The convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of autism. Efforts have been devoted to exploring the behavioural functions, key pathological mechanisms and potential treatments of autism. Here, as we highlight in this review, emerging evidence shows that signal transduction molecular events are involved in pathological processes such as transcription, translation, synaptic transmission, epigenetics and immunoinflammatory responses. This involvement has important implications for the discovery of precise molecular targets for autism. Moreover, we review recent insights into the mechanisms and clinical implications of signal transduction in autism from molecular, cellular, neural circuit, and neurobehavioural aspects. Finally, the challenges and future perspectives are discussed with regard to novel strategies predicated on the biological features of autism." @default.
- W4285008675 created "2022-07-12" @default.
- W4285008675 creator A5027220663 @default.
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- W4285008675 creator A5082175198 @default.
- W4285008675 creator A5091324614 @default.
- W4285008675 date "2022-07-11" @default.
- W4285008675 modified "2023-10-13" @default.
- W4285008675 title "Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications" @default.
- W4285008675 cites W1067107096 @default.
- W4285008675 cites W1168911763 @default.
- W4285008675 cites W1409858176 @default.
- W4285008675 cites W1481790771 @default.
- W4285008675 cites W1486257535 @default.
- W4285008675 cites W1491762297 @default.
- W4285008675 cites W1498791230 @default.
- W4285008675 cites W1499167392 @default.
- W4285008675 cites W1501029124 @default.
- W4285008675 cites W1502695427 @default.
- W4285008675 cites W1511752676 @default.
- W4285008675 cites W1515023627 @default.
- W4285008675 cites W1521522959 @default.
- W4285008675 cites W1541267199 @default.
- W4285008675 cites W1546762987 @default.
- W4285008675 cites W1546926080 @default.
- W4285008675 cites W1559742681 @default.
- W4285008675 cites W1563129071 @default.
- W4285008675 cites W1580790875 @default.
- W4285008675 cites W1597533526 @default.
- W4285008675 cites W1621052465 @default.
- W4285008675 cites W1759848617 @default.
- W4285008675 cites W1768523798 @default.
- W4285008675 cites W1777711993 @default.
- W4285008675 cites W1884253317 @default.
- W4285008675 cites W1894892328 @default.
- W4285008675 cites W1944530972 @default.
- W4285008675 cites W1963736913 @default.
- W4285008675 cites W1964337986 @default.
- W4285008675 cites W1964358779 @default.
- W4285008675 cites W1964372429 @default.
- W4285008675 cites W1964444099 @default.
- W4285008675 cites W1964629798 @default.
- W4285008675 cites W1965210252 @default.
- W4285008675 cites W1965218838 @default.
- W4285008675 cites W1965263998 @default.
- W4285008675 cites W1966097738 @default.
- W4285008675 cites W1966761076 @default.
- W4285008675 cites W1968659204 @default.
- W4285008675 cites W1968975115 @default.
- W4285008675 cites W1969615942 @default.
- W4285008675 cites W1970038529 @default.
- W4285008675 cites W1971850026 @default.
- W4285008675 cites W1973138133 @default.
- W4285008675 cites W1973477241 @default.
- W4285008675 cites W1973491179 @default.
- W4285008675 cites W1974024551 @default.
- W4285008675 cites W1974659994 @default.
- W4285008675 cites W1974814280 @default.
- W4285008675 cites W1975890560 @default.
- W4285008675 cites W1975931018 @default.
- W4285008675 cites W1976666730 @default.
- W4285008675 cites W1976684277 @default.
- W4285008675 cites W1976980117 @default.
- W4285008675 cites W1977087590 @default.
- W4285008675 cites W1977497843 @default.
- W4285008675 cites W1977514547 @default.
- W4285008675 cites W1979421307 @default.
- W4285008675 cites W1979622085 @default.
- W4285008675 cites W1980176764 @default.
- W4285008675 cites W1980625058 @default.
- W4285008675 cites W1980789245 @default.
- W4285008675 cites W1981435333 @default.
- W4285008675 cites W1981640964 @default.
- W4285008675 cites W1981744250 @default.
- W4285008675 cites W1982054620 @default.
- W4285008675 cites W1982811887 @default.
- W4285008675 cites W1983934432 @default.
- W4285008675 cites W1984124345 @default.
- W4285008675 cites W1984369088 @default.
- W4285008675 cites W1986890804 @default.
- W4285008675 cites W1987314226 @default.
- W4285008675 cites W1988011192 @default.
- W4285008675 cites W1988181440 @default.
- W4285008675 cites W1988670106 @default.
- W4285008675 cites W1988743524 @default.
- W4285008675 cites W1989131196 @default.
- W4285008675 cites W1991144297 @default.
- W4285008675 cites W1991378696 @default.
- W4285008675 cites W1991721037 @default.
- W4285008675 cites W1992530750 @default.
- W4285008675 cites W1992748173 @default.
- W4285008675 cites W1993106553 @default.
- W4285008675 cites W1993537924 @default.
- W4285008675 cites W1993719074 @default.
- W4285008675 cites W1993988720 @default.
- W4285008675 cites W1995048468 @default.
- W4285008675 cites W1995470989 @default.