FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285010090> ?p ?o ?g. }

• W4285010090 endingPage "154336" @default.
• W4285010090 startingPage "154336" @default.
• W4285010090 abstract "The pathogenesis of myocardial ischemia/reperfusion is complex, involving multiple regulatory genes and environmental factors, and requiring the simultaneous regulation of multiple targets. Meanwhile, Traditional Chinese Medicine (TCM) has certain advantages in the comprehensive treatment of multi-site, multi-target conditions and overall regulation of this condition. This study explores the effect of the well-known TCM, the Shexiang Baoxin Pill (SBP) on myocardial ischemia/reperfusion injury in mice. In vivo, 20 mg/kg/day SBP was administered by gavage for 28 days. In vitro, cardiomyocytes were pretreated with 25 μg/ml SBP for 24 h. Evans blue/TTC double-staining was employed to determine the infarct size. Markers of myocardial injury were detected in the serum and cell supernatants. The changes of pyroptosis and autophagy proteins were detected by western blot. Immunofluorescence, immunohistochemistry and PCR were performed to further illustrate the results. SBP significantly reduced the myocardial infarct size, decreased the myocardial injury markers, inhibited cardiomyocyte pyroptosis and oxidative stress, and promoted autophagy in vivo. In vitro, SBP alleviated cardiomyocyte pyroptosis, inhibited oxidative stress, reduced IL-1β and IL-18 secretion, and unblocked autophagy flux. Myocardial injury is mitigated by SBP via the rapid degradation of autophagosomes, and SBP promotes the accumulation of autophagosomes by downregulating mmu_circ_0005874, Map3k8 and upregulating mmu-miR-543-3p. We found for the first time that SBP can inhibit pyroptosis and oxidative stress, and protect from myocardial I/R injury. In addition, it inhibits pyroptosis and improves H/R injury by promoting autophagosome generation and accelerating autophagic flux. SBP interferes with autophagy through the interaction between mmu_circ_0005874/mmu-miR-543-3p/Map3k8." @default.
• W4285010090 created "2022-07-12" @default.
• W4285010090 creator A5002076661 @default.
• W4285010090 creator A5023496361 @default.
• W4285010090 creator A5029748241 @default.
• W4285010090 creator A5039978170 @default.
• W4285010090 creator A5057728157 @default.
• W4285010090 creator A5059087344 @default.
• W4285010090 creator A5069560545 @default.
• W4285010090 creator A5079268343 @default.
• W4285010090 creator A5080384801 @default.
• W4285010090 date "2022-09-01" @default.
• W4285010090 modified "2023-10-16" @default.
• W4285010090 title "Shexiang Baoxin Pill attenuates myocardial ischemia/reperfusion injury by activating autophagy via modulating the ceRNA-Map3k8 pathway" @default.
• W4285010090 cites W2132069300 @default.
• W4285010090 cites W2163207768 @default.
• W4285010090 cites W2256669978 @default.
• W4285010090 cites W2487234715 @default.
• W4285010090 cites W2521940161 @default.
• W4285010090 cites W2529921966 @default.
• W4285010090 cites W2556644173 @default.
• W4285010090 cites W2559869493 @default.
• W4285010090 cites W2732255066 @default.
• W4285010090 cites W2735882751 @default.
• W4285010090 cites W2781279551 @default.
• W4285010090 cites W2790639501 @default.
• W4285010090 cites W2794752206 @default.
• W4285010090 cites W2883123213 @default.
• W4285010090 cites W2897342629 @default.
• W4285010090 cites W2903986976 @default.
• W4285010090 cites W2907511830 @default.
• W4285010090 cites W2945385843 @default.
• W4285010090 cites W2952383255 @default.
• W4285010090 cites W2989316982 @default.
• W4285010090 cites W2994346287 @default.
• W4285010090 cites W3030644755 @default.
• W4285010090 cites W3092540339 @default.
• W4285010090 cites W3126600322 @default.
• W4285010090 cites W3134354838 @default.
• W4285010090 cites W3157177343 @default.
• W4285010090 cites W3158007579 @default.
• W4285010090 cites W3161208341 @default.
• W4285010090 cites W3199612967 @default.
• W4285010090 cites W4207082512 @default.
• W4285010090 cites W4221064587 @default.
• W4285010090 cites W4320301265 @default.
• W4285010090 doi "https://doi.org/10.1016/j.phymed.2022.154336" @default.
• W4285010090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35849969" @default.
• W4285010090 hasPublicationYear "2022" @default.
• W4285010090 type Work @default.
• W4285010090 citedByCount "6" @default.
• W4285010090 countsByYear W42850100902022 @default.
• W4285010090 countsByYear W42850100902023 @default.
• W4285010090 crossrefType "journal-article" @default.
• W4285010090 hasAuthorship W4285010090A5002076661 @default.
• W4285010090 hasAuthorship W4285010090A5023496361 @default.
• W4285010090 hasAuthorship W4285010090A5029748241 @default.
• W4285010090 hasAuthorship W4285010090A5039978170 @default.
• W4285010090 hasAuthorship W4285010090A5057728157 @default.
• W4285010090 hasAuthorship W4285010090A5059087344 @default.
• W4285010090 hasAuthorship W4285010090A5069560545 @default.
• W4285010090 hasAuthorship W4285010090A5079268343 @default.
• W4285010090 hasAuthorship W4285010090A5080384801 @default.
• W4285010090 hasBestOaLocation W42850100901 @default.
• W4285010090 hasConcept C104317684 @default.
• W4285010090 hasConcept C126322002 @default.
• W4285010090 hasConcept C150903083 @default.
• W4285010090 hasConcept C168296220 @default.
• W4285010090 hasConcept C17172800 @default.
• W4285010090 hasConcept C185592680 @default.
• W4285010090 hasConcept C190283241 @default.
• W4285010090 hasConcept C203522944 @default.
• W4285010090 hasConcept C207001950 @default.
• W4285010090 hasConcept C2776151105 @default.
• W4285010090 hasConcept C2776415932 @default.
• W4285010090 hasConcept C2780114680 @default.
• W4285010090 hasConcept C31573885 @default.
• W4285010090 hasConcept C541997718 @default.
• W4285010090 hasConcept C55493867 @default.
• W4285010090 hasConcept C71924100 @default.
• W4285010090 hasConcept C86803240 @default.
• W4285010090 hasConcept C95444343 @default.
• W4285010090 hasConcept C98274493 @default.
• W4285010090 hasConceptScore W4285010090C104317684 @default.
• W4285010090 hasConceptScore W4285010090C126322002 @default.
• W4285010090 hasConceptScore W4285010090C150903083 @default.
• W4285010090 hasConceptScore W4285010090C168296220 @default.
• W4285010090 hasConceptScore W4285010090C17172800 @default.
• W4285010090 hasConceptScore W4285010090C185592680 @default.
• W4285010090 hasConceptScore W4285010090C190283241 @default.
• W4285010090 hasConceptScore W4285010090C203522944 @default.
• W4285010090 hasConceptScore W4285010090C207001950 @default.
• W4285010090 hasConceptScore W4285010090C2776151105 @default.
• W4285010090 hasConceptScore W4285010090C2776415932 @default.
• W4285010090 hasConceptScore W4285010090C2780114680 @default.
• W4285010090 hasConceptScore W4285010090C31573885 @default.
• W4285010090 hasConceptScore W4285010090C541997718 @default.
• W4285010090 hasConceptScore W4285010090C55493867 @default.

• next