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• W4285011907 endingPage "e0268483" @default.
• W4285011907 startingPage "e0268483" @default.
• W4285011907 abstract "Objective We compared diagnostic accuracy of pleural fluid Xpert MTB/RIF (Xpert) and Xpert MTB/RIF Ultra (Ultra) assays for diagnosing tuberculous pleural effusion (TPE), through systematic review and comparative meta-analysis. Methods We searched PubMed and Embase databases for publications reporting diagnostic accuracy of Xpert or Ultra for TPE. We used bivariate random-effects modeling to summarize diagnostic accuracy information from individual studies using either mycobacterial culture or composite criteria as reference standard. We performed meta-regression through hierarchical summary receiver operating characteristic (HSROC) modeling to evaluate comparative performance of the two tests from studies reporting diagnostic accuracy of both in the same study population. Results We retrieved 1097 publications, and included 74 for review. Summary estimates for sensitivity and specificity for Xpert were 0.52 (95% CI 0.43–0.60, I 2 82.1%) and 0.99 (95% CI 0.97–0.99, I 2 85.1%), respectively, using culture-based reference standard; and 0.21 (95% CI 0.17–0.26, I 2 81.5%) and 1.00 (95% CI 0.99–1.00, I 2 37.6%), respectively, using composite reference standard. Summary estimates for sensitivity and specificity for Ultra were 0.68 (95% CI 0.55–0.79, I 2 80.0%) and 0.97 (95% CI 0.97–0.99, I 2 92.1%), respectively, using culture-based reference standard; and 0.47 (95% CI 0.40–0.55, I 2 64.1%) and 0.98 (95% CI 0.95–0.99, I 2 54.8%), respectively, using composite reference standard. HSROC meta-regression yielded relative diagnostic odds ratio of 1.28 (95% CI 0.65–2.50) and 1.80 (95% CI 0.41–7.84) respectively in favor of Ultra, using culture and composite criteria as reference standard. Conclusion Ultra provides superior diagnostic accuracy over Xpert for diagnosing TPE, mainly because of its higher sensitivity." @default.
• W4285011907 created "2022-07-12" @default.
• W4285011907 creator A5007001363 @default.
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• W4285011907 creator A5059063644 @default.
• W4285011907 creator A5065012664 @default.
• W4285011907 creator A5076452609 @default.
• W4285011907 date "2022-07-11" @default.
• W4285011907 modified "2023-10-11" @default.
• W4285011907 title "Xpert MTB/RIF Ultra versus Xpert MTB/RIF for diagnosis of tuberculous pleural effusion: A systematic review and comparative meta-analysis" @default.
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