FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285012936> ?p ?o ?g. }

• W4285012936 abstract "Background: Here, we establish a prognostic signature based on glycosyltransferase-related genes (GTRGs) for head and neck squamous cell carcinoma (HNSCC) patients. Methods: The prognostic signature of GTRGs was constructed via univariate and multivariate Cox analyses after obtaining the expression patterns of GTRGs from the TCGA. A nomogram based on the signature and clinical parameters was established to predict the survival of each HNSCC patient. Potential mechanisms were explored through gene set enrichment analysis (GSEA) and immune cell infiltration, immune checkpoints, immunotherapy, and tumor mutational burden (TMB) analyses. The expression differences and prognostic efficacy of the signature were verified through the gene expression omnibus (GEO) and several online databases. Results: The prognostic signature was constructed based on five glycosyltransferases (PYGL, ALG3, EXT2, FUT2, and KDELC1) and validated in the GSE65858 dataset. The pathways enriched in the high- and low-risk groups were significantly different. The high-risk group had higher tumor purity; lower infiltration of immune cells, such as CD8 + T cells and Tregs; higher cancer-associated fibroblast (CAF) infiltration; lower immune function; and lower checkpoint expression. The signature can also be applied to distinguish whether patients benefit from immunotherapy. In addition, the high-risk group had a higher TMB and more gene mutations, including those in TP53, CSMD1, CDKN2A, and MUC17. Conclusion: We propose a prognostic signature based on glycosyltransferases for HNSCC patients that may provide potential targets and biomarkers for the precise treatment of HNSCC." @default.
• W4285012936 created "2022-07-12" @default.
• W4285012936 creator A5003672798 @default.
• W4285012936 creator A5007183851 @default.
• W4285012936 creator A5009835732 @default.
• W4285012936 creator A5036154770 @default.
• W4285012936 creator A5056600496 @default.
• W4285012936 creator A5069662207 @default.
• W4285012936 creator A5075712417 @default.
• W4285012936 date "2022-07-11" @default.
• W4285012936 modified "2023-10-05" @default.
• W4285012936 title "A Glycosyltransferase-Related Signature for Predicting Overall Survival in Head and Neck Squamous Cell Carcinoma" @default.
• W4285012936 cites W1182461782 @default.
• W4285012936 cites W1560222015 @default.
• W4285012936 cites W1583511338 @default.
• W4285012936 cites W1583958653 @default.
• W4285012936 cites W1940064707 @default.
• W4285012936 cites W1982478212 @default.
• W4285012936 cites W1984853905 @default.
• W4285012936 cites W1999321257 @default.
• W4285012936 cites W2017322644 @default.
• W4285012936 cites W2029862112 @default.
• W4285012936 cites W2049018701 @default.
• W4285012936 cites W2107429737 @default.
• W4285012936 cites W2116910749 @default.
• W4285012936 cites W2128490578 @default.
• W4285012936 cites W2159153444 @default.
• W4285012936 cites W2165711096 @default.
• W4285012936 cites W2189636949 @default.
• W4285012936 cites W2301744235 @default.
• W4285012936 cites W2341068828 @default.
• W4285012936 cites W2617373620 @default.
• W4285012936 cites W2619691134 @default.
• W4285012936 cites W2758892165 @default.
• W4285012936 cites W2761575992 @default.
• W4285012936 cites W2785291766 @default.
• W4285012936 cites W2786031287 @default.
• W4285012936 cites W2882970439 @default.
• W4285012936 cites W2883399815 @default.
• W4285012936 cites W2883960811 @default.
• W4285012936 cites W2884397271 @default.
• W4285012936 cites W2888275449 @default.
• W4285012936 cites W2891028736 @default.
• W4285012936 cites W2901515128 @default.
• W4285012936 cites W2903395613 @default.
• W4285012936 cites W2909292083 @default.
• W4285012936 cites W2919977068 @default.
• W4285012936 cites W2920979786 @default.
• W4285012936 cites W2970289072 @default.
• W4285012936 cites W2991341799 @default.
• W4285012936 cites W2996960833 @default.
• W4285012936 cites W3029490475 @default.
• W4285012936 cites W3080897172 @default.
• W4285012936 cites W3094407181 @default.
• W4285012936 cites W3102118357 @default.
• W4285012936 cites W3112593377 @default.
• W4285012936 cites W3118393823 @default.
• W4285012936 cites W3119588209 @default.
• W4285012936 cites W3123868968 @default.
• W4285012936 cites W3157750438 @default.
• W4285012936 cites W3162528221 @default.
• W4285012936 cites W3170446207 @default.
• W4285012936 cites W3184734893 @default.
• W4285012936 cites W3186253469 @default.
• W4285012936 cites W3194599077 @default.
• W4285012936 cites W3198936310 @default.
• W4285012936 cites W4200175092 @default.
• W4285012936 doi "https://doi.org/10.3389/fgene.2022.856671" @default.
• W4285012936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35899200" @default.
• W4285012936 hasPublicationYear "2022" @default.
• W4285012936 type Work @default.
• W4285012936 citedByCount "3" @default.
• W4285012936 countsByYear W42850129362022 @default.
• W4285012936 countsByYear W42850129362023 @default.
• W4285012936 crossrefType "journal-article" @default.
• W4285012936 hasAuthorship W4285012936A5003672798 @default.
• W4285012936 hasAuthorship W4285012936A5007183851 @default.
• W4285012936 hasAuthorship W4285012936A5009835732 @default.
• W4285012936 hasAuthorship W4285012936A5036154770 @default.
• W4285012936 hasAuthorship W4285012936A5056600496 @default.
• W4285012936 hasAuthorship W4285012936A5069662207 @default.
• W4285012936 hasAuthorship W4285012936A5075712417 @default.
• W4285012936 hasBestOaLocation W42850129361 @default.
• W4285012936 hasConcept C104317684 @default.
• W4285012936 hasConcept C121608353 @default.
• W4285012936 hasConcept C126322002 @default.
• W4285012936 hasConcept C143998085 @default.
• W4285012936 hasConcept C150194340 @default.
• W4285012936 hasConcept C203014093 @default.
• W4285012936 hasConcept C2776530083 @default.
• W4285012936 hasConcept C2776833033 @default.
• W4285012936 hasConcept C2777701055 @default.
• W4285012936 hasConcept C2779733811 @default.
• W4285012936 hasConcept C2780265364 @default.
• W4285012936 hasConcept C34626388 @default.
• W4285012936 hasConcept C502942594 @default.
• W4285012936 hasConcept C54355233 @default.
• W4285012936 hasConcept C71924100 @default.
• W4285012936 hasConcept C86803240 @default.
• W4285012936 hasConcept C8891405 @default.

• next