Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285013755> ?p ?o ?g. }
- W4285013755 endingPage "2034" @default.
- W4285013755 startingPage "2034" @default.
- W4285013755 abstract "Mulberry leaf protein is a potentially functional food component and health care agent with antioxidant and anti-inflammatory properties. However, its composition, immunoregulatory effects, and gut microbial regulatory effects are unclear. Herein, ultra-filtrated and gel-fractionated mulberry leaf protein (GUMP) was characterized. Its effects on cyclophosphamide-induced immunosuppressed mice were further investigated. The results indicated that GUMP is a glycoprotein mainly containing glucose, arabinose, and mannose with 9.23% total sugar content. Its secondary structure is mainly β-sheet. LC-MS/MS analysis showed that GUMP closely matched with a 16.7 kDa mannose-binding lectin and a 52.7 kDa Rubisco's large subunit. GUMP intervention significantly improved serous TNF-α, IL-6, and IL-2 contents; increased serum immunoglobulins (IgA and IgG) levels; and reversed splenic damage prominently. Moreover, GUMP administration increased fecal shot-chain fatty acid concentration and up-regulated the relative abundance of Odoribacter, which was positively correlated with SCFAs and cytokine contents. Overall, GUMP alleviated immunosuppression through the integrated modulation of the gut microbiota and immune response. Therefore, GUMP could be a promising dietary supplement to help maintain gut health." @default.
- W4285013755 created "2022-07-12" @default.
- W4285013755 creator A5019567495 @default.
- W4285013755 creator A5022826172 @default.
- W4285013755 creator A5024825186 @default.
- W4285013755 creator A5028580564 @default.
- W4285013755 creator A5034252676 @default.
- W4285013755 creator A5037473430 @default.
- W4285013755 creator A5055233824 @default.
- W4285013755 creator A5077042443 @default.
- W4285013755 date "2022-07-09" @default.
- W4285013755 modified "2023-10-03" @default.
- W4285013755 title "Characterization of Purified Mulberry Leaf Glycoprotein and Its Immunoregulatory Effect on Cyclophosphamide-Treated Mice" @default.
- W4285013755 cites W1563946068 @default.
- W4285013755 cites W1830456351 @default.
- W4285013755 cites W1973976214 @default.
- W4285013755 cites W1974741460 @default.
- W4285013755 cites W1977605607 @default.
- W4285013755 cites W1985931830 @default.
- W4285013755 cites W1990590570 @default.
- W4285013755 cites W1996718803 @default.
- W4285013755 cites W2032519377 @default.
- W4285013755 cites W2036460351 @default.
- W4285013755 cites W2037199116 @default.
- W4285013755 cites W2054737033 @default.
- W4285013755 cites W2055533912 @default.
- W4285013755 cites W2059128083 @default.
- W4285013755 cites W2074664462 @default.
- W4285013755 cites W2078224825 @default.
- W4285013755 cites W2128701728 @default.
- W4285013755 cites W2139205910 @default.
- W4285013755 cites W2160157792 @default.
- W4285013755 cites W2197167222 @default.
- W4285013755 cites W2231211582 @default.
- W4285013755 cites W2313857605 @default.
- W4285013755 cites W2521392361 @default.
- W4285013755 cites W2534370812 @default.
- W4285013755 cites W2586104683 @default.
- W4285013755 cites W2590776674 @default.
- W4285013755 cites W2742196080 @default.
- W4285013755 cites W2767281334 @default.
- W4285013755 cites W2790541566 @default.
- W4285013755 cites W2886690355 @default.
- W4285013755 cites W2887685933 @default.
- W4285013755 cites W2888585822 @default.
- W4285013755 cites W2892783528 @default.
- W4285013755 cites W2907048060 @default.
- W4285013755 cites W2911438199 @default.
- W4285013755 cites W2920541859 @default.
- W4285013755 cites W2920748824 @default.
- W4285013755 cites W2944364661 @default.
- W4285013755 cites W3012976608 @default.
- W4285013755 cites W3018966941 @default.
- W4285013755 cites W3019767571 @default.
- W4285013755 cites W3026296114 @default.
- W4285013755 cites W3080162796 @default.
- W4285013755 cites W3080546592 @default.
- W4285013755 cites W3088749890 @default.
- W4285013755 cites W3094472824 @default.
- W4285013755 cites W3097706436 @default.
- W4285013755 cites W3107232065 @default.
- W4285013755 cites W3111286424 @default.
- W4285013755 cites W3113049436 @default.
- W4285013755 cites W3131608869 @default.
- W4285013755 cites W3159003956 @default.
- W4285013755 cites W3160731538 @default.
- W4285013755 cites W3160969910 @default.
- W4285013755 cites W3175275804 @default.
- W4285013755 cites W3177203509 @default.
- W4285013755 cites W3184394175 @default.
- W4285013755 cites W3188139486 @default.
- W4285013755 cites W3193322557 @default.
- W4285013755 cites W3193342690 @default.
- W4285013755 cites W3208090959 @default.
- W4285013755 cites W4214589408 @default.
- W4285013755 doi "https://doi.org/10.3390/foods11142034" @default.
- W4285013755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35885277" @default.
- W4285013755 hasPublicationYear "2022" @default.
- W4285013755 type Work @default.
- W4285013755 citedByCount "2" @default.
- W4285013755 countsByYear W42850137552023 @default.
- W4285013755 crossrefType "journal-article" @default.
- W4285013755 hasAuthorship W4285013755A5019567495 @default.
- W4285013755 hasAuthorship W4285013755A5022826172 @default.
- W4285013755 hasAuthorship W4285013755A5024825186 @default.
- W4285013755 hasAuthorship W4285013755A5028580564 @default.
- W4285013755 hasAuthorship W4285013755A5034252676 @default.
- W4285013755 hasAuthorship W4285013755A5037473430 @default.
- W4285013755 hasAuthorship W4285013755A5055233824 @default.
- W4285013755 hasAuthorship W4285013755A5077042443 @default.
- W4285013755 hasBestOaLocation W42850137551 @default.
- W4285013755 hasConcept C100817775 @default.
- W4285013755 hasConcept C185592680 @default.
- W4285013755 hasConcept C203014093 @default.
- W4285013755 hasConcept C2775887612 @default.
- W4285013755 hasConcept C2776600866 @default.
- W4285013755 hasConcept C2779719659 @default.
- W4285013755 hasConcept C2780758401 @default.