FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285013758> ?p ?o ?g. }

• W4285013758 endingPage "e0271205" @default.
• W4285013758 startingPage "e0271205" @default.
• W4285013758 abstract "Recent studies demonstrate that immune checkpoint blockade (ICB) increases the chances of the abscopal effect, an anti-tumor effect outside the radiation field in radiation therapy. However, the optimal sequence between radiation and ICB remains unclear. To investigate the impact of sequence of radiation in anti-PD-L1 antibody (P1) therapy on immune microenvironments and antitumor efficacies in local and abscopal tumors, metastatic LM8 osteosarcoma cells were inoculated into both legs of C3H mice. For irradiation, only one side leg was irradiated at 10 Gy. Then mice were divided into four groups: administrated anti-PD-L1 antibody three times (P1 monotherapy), receiving radiation 3 days prior to P1 therapy (P1+pre-Rad), and receiving concurrent radiation with P1 therapy (P1+conc-Rad). Thereafter, tumor immune microenvironment and tumor volume changes were analyzed in irradiated and unirradiated tumors. The P1+pre-Rad regimen increased the proportion of CD8+ programmed cell death 1 (PD-1)+ granzyme B (GzmB)+ reinvigorated T cells and decreased the proportion of CD8+ PD-1+ GzmB- exhausted T cells than P1+conc-Rad regimen in unirradiated tumors. Combination regimens suppressed tumor growth in irradiated tumors compared with that in P1 monotherapy. In both irradiated and unirradiated tumors, significant tumor growth suppression and prolonged overall survival were observed under both combination treatment regimens compared with P1 monotherapy. However, no distinct differences in unirradiated tumor volume and survival were observed between P1+pre-Rad and P1+conc-Rad groups. These results suggest that local irradiation is necessary to improve systemic treatment efficacy in P1 therapy regardless of sequence of local irradiation." @default.
• W4285013758 created "2022-07-12" @default.
• W4285013758 creator A5000243750 @default.
• W4285013758 creator A5007395123 @default.
• W4285013758 creator A5007661524 @default.
• W4285013758 creator A5016365832 @default.
• W4285013758 creator A5020311322 @default.
• W4285013758 creator A5032696096 @default.
• W4285013758 creator A5035321311 @default.
• W4285013758 creator A5036525621 @default.
• W4285013758 creator A5045000295 @default.
• W4285013758 creator A5051543374 @default.
• W4285013758 creator A5059947593 @default.
• W4285013758 creator A5071585451 @default.
• W4285013758 creator A5081044448 @default.
• W4285013758 date "2022-07-11" @default.
• W4285013758 modified "2023-09-26" @default.
• W4285013758 title "Radiation therapy enhances systemic antitumor efficacy in PD-L1 therapy regardless of sequence of radiation in murine osteosarcoma" @default.
• W4285013758 cites W1823658262 @default.
• W4285013758 cites W1856075116 @default.
• W4285013758 cites W1970888620 @default.
• W4285013758 cites W2022208959 @default.
• W4285013758 cites W2022837929 @default.
• W4285013758 cites W2022996006 @default.
• W4285013758 cites W2032166347 @default.
• W4285013758 cites W2038179631 @default.
• W4285013758 cites W2039664986 @default.
• W4285013758 cites W2045963664 @default.
• W4285013758 cites W2052727153 @default.
• W4285013758 cites W2053393698 @default.
• W4285013758 cites W2054076973 @default.
• W4285013758 cites W2063264144 @default.
• W4285013758 cites W2080083059 @default.
• W4285013758 cites W2091753221 @default.
• W4285013758 cites W2091761369 @default.
• W4285013758 cites W2093424661 @default.
• W4285013758 cites W2100928937 @default.
• W4285013758 cites W2119896120 @default.
• W4285013758 cites W2122940327 @default.
• W4285013758 cites W2127892610 @default.
• W4285013758 cites W2132285742 @default.
• W4285013758 cites W2143163879 @default.
• W4285013758 cites W2159094759 @default.
• W4285013758 cites W2177332611 @default.
• W4285013758 cites W2341604280 @default.
• W4285013758 cites W2400074984 @default.
• W4285013758 cites W2560628113 @default.
• W4285013758 cites W2572174216 @default.
• W4285013758 cites W2587330058 @default.
• W4285013758 cites W2762797139 @default.
• W4285013758 cites W2777743591 @default.
• W4285013758 cites W2789660401 @default.
• W4285013758 cites W2809506522 @default.
• W4285013758 cites W2908530651 @default.
• W4285013758 cites W3005802010 @default.
• W4285013758 cites W3014516696 @default.
• W4285013758 cites W3035332934 @default.
• W4285013758 cites W4235927881 @default.
• W4285013758 doi "https://doi.org/10.1371/journal.pone.0271205" @default.
• W4285013758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35816501" @default.
• W4285013758 hasPublicationYear "2022" @default.
• W4285013758 type Work @default.
• W4285013758 citedByCount "4" @default.
• W4285013758 countsByYear W42850137582022 @default.
• W4285013758 countsByYear W42850137582023 @default.
• W4285013758 crossrefType "journal-article" @default.
• W4285013758 hasAuthorship W4285013758A5000243750 @default.
• W4285013758 hasAuthorship W4285013758A5007395123 @default.
• W4285013758 hasAuthorship W4285013758A5007661524 @default.
• W4285013758 hasAuthorship W4285013758A5016365832 @default.
• W4285013758 hasAuthorship W4285013758A5020311322 @default.
• W4285013758 hasAuthorship W4285013758A5032696096 @default.
• W4285013758 hasAuthorship W4285013758A5035321311 @default.
• W4285013758 hasAuthorship W4285013758A5036525621 @default.
• W4285013758 hasAuthorship W4285013758A5045000295 @default.
• W4285013758 hasAuthorship W4285013758A5051543374 @default.
• W4285013758 hasAuthorship W4285013758A5059947593 @default.
• W4285013758 hasAuthorship W4285013758A5071585451 @default.
• W4285013758 hasAuthorship W4285013758A5081044448 @default.
• W4285013758 hasBestOaLocation W42850137581 @default.
• W4285013758 hasConcept C126322002 @default.
• W4285013758 hasConcept C143998085 @default.
• W4285013758 hasConcept C167672396 @default.
• W4285013758 hasConcept C203014093 @default.
• W4285013758 hasConcept C2776107976 @default.
• W4285013758 hasConcept C2776999253 @default.
• W4285013758 hasConcept C2777701055 @default.
• W4285013758 hasConcept C2777760704 @default.
• W4285013758 hasConcept C2780851360 @default.
• W4285013758 hasConcept C2781274730 @default.
• W4285013758 hasConcept C2781413609 @default.
• W4285013758 hasConcept C2989005 @default.
• W4285013758 hasConcept C502942594 @default.
• W4285013758 hasConcept C509974204 @default.
• W4285013758 hasConcept C71924100 @default.
• W4285013758 hasConcept C8891405 @default.
• W4285013758 hasConceptScore W4285013758C126322002 @default.
• W4285013758 hasConceptScore W4285013758C143998085 @default.

• next