FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285013963> ?p ?o ?g. }

• W4285013963 abstract "In the Republic of Sakha (Yakutia), persistently high incidence rates of CVH remain, as well as mortality rates from complications of liver cirrhosis (LC), as the most common complication. It seems relevant to search for genetic predictors of early development of severe complications in CVH patients in the Yakut population. They can be polymorphic variants of the genes for endothelial dysfunction and oxidative stress NOS3 and CYBA. The collection of representative material was carried out on the basis of the Infectious Diseases Department of the State Budgetary Institution of the Republic of Sakha (Yakutia) of the Yakut Republican Clinical Hospital. In total, 47 DNA samples of patients with chronic viral hepatitis В and liver cirrhosis in its outcome, hospitalized in the Infectious Diseases Department from September 2020 to June 2021, were studied. The control group consisted of patients not infected with viral hepatitis, as well as without pathology of the hemostasis system. The experimental part of the study was carried out by real-time PCR with the melting of hybridization products with a fluorescent label, followed by analysis of the RealBest-Genetics melting curves. As a result of the PCR-RFLP analysis of the rs1799983 polymorphism of the NOS3 gene among patients with chronic viral hepatitis, the T allele frequency was 0.09, and the G allele frequency was 0.91. The frequency of the C allele of the rs2070744 polymorphism of the NOS3 gene was 0.05, the frequency of the T allele was 0.95. The frequency of occurrence of the major allele C of the rs4673 polymorphism of the CYBA gene was 0.78, the minor allele T was 0.22. The relationship between the carriage of polymorphisms of these genes and the disease was not found. However, it was found that carriers of the mutant allele for the rs1799983 polymorphism of the NOS3 gene were 1.81 times more likely to develop liver cirrhosis (95 % CI, odds in the groups 0.176–0.098), carriers of the mutant allele for the rs4673 polymorphism of the CYBA gene were more likely to develop cirrhosis liver cirrhosis is 1.9 times higher (95 % CI, odds in groups 0.211–0.111), in carriers of the mutant allele for the rs2070744 polymorphism of the NOS3 gene, the probability of developing liver cirrhosis is 2.03 times higher (95 % CI, odds in groups 0.181–0.089 ). In carriers of the mutant allele for the rs4673 polymorphism of the CYBA gene, shortening of PT and APTT (17.79 ± 10.26 and 35.13 ± 7.82 sec) is observed, which may indicate a greater tendency of this group to hypercoagulability. In carriers of the mutant allele for the rs2070744 polymorphism of the NOS3 gene, shortening of PT and APTT (11.56 ± 0.99 and 30.12 ± 4.45 sec) is observed, which may also indicate a greater tendency of this group to hypercoagulability." @default.
• W4285013963 created "2022-07-12" @default.
• W4285013963 creator A5002548266 @default.
• W4285013963 creator A5036434748 @default.
• W4285013963 date "2022-06-30" @default.
• W4285013963 modified "2023-09-26" @default.
• W4285013963 title "РОЛЬ ПОЛИМОРФИЗМОВ ГЕНОВ NOS3 И CYBA В ФОРМИРОВАНИИ ОСЛОЖНЕНИЙ ХРОНИЧЕСКОГО ВИРУСНОГО ГЕПАТИТА В Название объекта Название объекта в переводе ФИО автора / список авторов Место работы автора ORCID Ключевые слова Аннотация" @default.
• W4285013963 doi "https://doi.org/10.25587/svfu.2022.27.2.008" @default.
• W4285013963 hasPublicationYear "2022" @default.
• W4285013963 type Work @default.
• W4285013963 citedByCount "0" @default.
• W4285013963 crossrefType "journal-article" @default.
• W4285013963 hasAuthorship W4285013963A5002548266 @default.
• W4285013963 hasAuthorship W4285013963A5036434748 @default.
• W4285013963 hasBestOaLocation W42850139631 @default.
• W4285013963 hasConcept C104317684 @default.
• W4285013963 hasConcept C126322002 @default.
• W4285013963 hasConcept C180754005 @default.
• W4285013963 hasConcept C203014093 @default.
• W4285013963 hasConcept C2776455275 @default.
• W4285013963 hasConcept C2777072776 @default.
• W4285013963 hasConcept C2777214474 @default.
• W4285013963 hasConcept C2908647359 @default.
• W4285013963 hasConcept C37463918 @default.
• W4285013963 hasConcept C54355233 @default.
• W4285013963 hasConcept C71924100 @default.
• W4285013963 hasConcept C76252995 @default.
• W4285013963 hasConcept C86803240 @default.
• W4285013963 hasConcept C90924648 @default.
• W4285013963 hasConcept C99454951 @default.
• W4285013963 hasConceptScore W4285013963C104317684 @default.
• W4285013963 hasConceptScore W4285013963C126322002 @default.
• W4285013963 hasConceptScore W4285013963C180754005 @default.
• W4285013963 hasConceptScore W4285013963C203014093 @default.
• W4285013963 hasConceptScore W4285013963C2776455275 @default.
• W4285013963 hasConceptScore W4285013963C2777072776 @default.
• W4285013963 hasConceptScore W4285013963C2777214474 @default.
• W4285013963 hasConceptScore W4285013963C2908647359 @default.
• W4285013963 hasConceptScore W4285013963C37463918 @default.
• W4285013963 hasConceptScore W4285013963C54355233 @default.
• W4285013963 hasConceptScore W4285013963C71924100 @default.
• W4285013963 hasConceptScore W4285013963C76252995 @default.
• W4285013963 hasConceptScore W4285013963C86803240 @default.
• W4285013963 hasConceptScore W4285013963C90924648 @default.
• W4285013963 hasConceptScore W4285013963C99454951 @default.
• W4285013963 hasIssue "2(27)" @default.
• W4285013963 hasLocation W42850139631 @default.
• W4285013963 hasOpenAccess W4285013963 @default.
• W4285013963 hasPrimaryLocation W42850139631 @default.
• W4285013963 hasRelatedWork W1987839925 @default.
• W4285013963 hasRelatedWork W1997076034 @default.
• W4285013963 hasRelatedWork W2131724321 @default.
• W4285013963 hasRelatedWork W2138093122 @default.
• W4285013963 hasRelatedWork W2349760139 @default.
• W4285013963 hasRelatedWork W2517087858 @default.
• W4285013963 hasRelatedWork W2530203677 @default.
• W4285013963 hasRelatedWork W4315798409 @default.
• W4285013963 hasRelatedWork W96924620 @default.
• W4285013963 hasRelatedWork W2186956733 @default.
• W4285013963 isParatext "false" @default.
• W4285013963 isRetracted "false" @default.
• W4285013963 workType "article" @default.