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• W4285014458 abstract "Production of capsular polysaccharides in Staphylococcus aureus is transcriptionally regulated by a control region of the cap operon that consists of SigA- and SigB-dependent promoters. A large number of regulators have been shown to affect cap gene expression. However, regulation of capsule is only partially understood. Here we found that SarZ was another regulator that activated the cap genes through the SigA-dependent promoter. Gel electrophoresis mobility shift experiments revealed that SarZ is bound to a broad region of the cap promoter including the SigA-dependent promoter but mainly the downstream region. We demonstrated that activation of cap expression by SarZ was independent of MgrA, which also activated capsule through the SigA-dependent promoter. Our results further showed that oxidative stress with hydrogen peroxide (H2O2) treatments enhanced SarZ activation of cap expression, indicating that SarZ is able to sense oxidative stress to regulate capsule production. IMPORTANCE Expression of virulence genes in Staphylococcus aureus is affected by environmental cues and is regulated by a surprisingly large number of regulators. Much is still unknown about how virulence factors are regulated by environment cues at the molecular level. Capsule is an antiphagocytic virulence factor that is highly regulated. In this study, we found SarZ was an activator of capsule and that the regulation of capsule by SarZ was affected by oxidative stress. These results provide an example of how a virulence factor could be regulated in response to an environmental cue. As the host oxidative defense system plays an important role against S. aureus, this study contributes to a better understanding of virulence gene regulation and staphylococcal pathogenesis." @default.
• W4285014458 created "2022-07-12" @default.
• W4285014458 creator A5041071479 @default.
• W4285014458 creator A5063928643 @default.
• W4285014458 date "2022-08-16" @default.
• W4285014458 modified "2023-10-02" @default.
• W4285014458 title "Regulation of Staphylococcal Capsule by SarZ is SigA-Dependent" @default.
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• W4285014458 doi "https://doi.org/10.1128/jb.00152-22" @default.
• W4285014458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35862799" @default.
• W4285014458 hasPublicationYear "2022" @default.
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