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• W4285014503 abstract "The association between glucagon-like peptide-1 (GLP-1) receptor agonists and the risk of various kinds of thyroid disorders remains uncertain. We aimed to evaluate the relationship between the use of GLP-1 receptor agonists and the occurrence of 6 kinds of thyroid disorders. We searched PubMed (MEDLINE), EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science from database inception to 31 October 2021 to identify eligible randomized controlled trials (RCTs). We performed meta-analysis using a random-effects model to calculate risk ratios (RRs) and 95% confidence intervals (CIs). A total of 45 trials were included in the meta-analysis. Compared with placebo or other interventions, GLP-1 receptor agonists' use showed an association with an increased risk of overall thyroid disorders (RR 1.28, 95% CI 1.03-1.60). However, GLP-1 receptor agonists had no significant effects on the occurrence of thyroid cancer (RR 1.30, 95% CI 0.86-1.97), hyperthyroidism (RR 1.19, 95% CI 0.61-2.35), hypothyroidism (RR 1.22, 95% CI 0.80-1.87), thyroiditis (RR 1.83, 95% CI 0.51-6.57), thyroid mass (RR 1.17, 95% CI 0.43-3.20), and goiter (RR 1.17, 95% CI 0.74-1.86). Subgroup analyses and meta-regression analyses showed that underlying diseases, type of control, and trial durations were not related to the effect of GLP-1 receptor agonists on overall thyroid disorders (all P subgroup > 0.05). In conclusion, GLP-1 receptor agonists did not increase or decrease the risk of thyroid cancer, hyperthyroidism, hypothyroidism, thyroiditis, thyroid mass and goiter. However, due to the low incidence of these diseases, these findings need to be examined further.PROSPERO https://www.crd.york.ac.uk/prospero/, identifier: CRD42021289121." @default.
• W4285014503 created "2022-07-12" @default.
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• W4285014503 date "2022-07-11" @default.
• W4285014503 modified "2023-10-02" @default.
• W4285014503 title "Use of GLP-1 Receptor Agonists and Occurrence of Thyroid Disorders: a Meta-Analysis of Randomized Controlled Trials" @default.
• W4285014503 cites W1798757189 @default.
• W4285014503 cites W1976838333 @default.
• W4285014503 cites W1992055007 @default.
• W4285014503 cites W2003415509 @default.
• W4285014503 cites W2004409542 @default.
• W4285014503 cites W2011755276 @default.
• W4285014503 cites W2012425163 @default.
• W4285014503 cites W2015788437 @default.
• W4285014503 cites W2019513002 @default.
• W4285014503 cites W2023695436 @default.
• W4285014503 cites W2025872592 @default.
• W4285014503 cites W2033954313 @default.
• W4285014503 cites W2039526322 @default.
• W4285014503 cites W2050866589 @default.
• W4285014503 cites W2052793092 @default.
• W4285014503 cites W2067533175 @default.
• W4285014503 cites W2071835038 @default.
• W4285014503 cites W2098459806 @default.
• W4285014503 cites W2106709036 @default.
• W4285014503 cites W2107949845 @default.
• W4285014503 cites W2112763544 @default.
• W4285014503 cites W2112981414 @default.
• W4285014503 cites W2113367996 @default.
• W4285014503 cites W2114027444 @default.
• W4285014503 cites W2120141122 @default.
• W4285014503 cites W2124977666 @default.
• W4285014503 cites W2139401663 @default.
• W4285014503 cites W2140004965 @default.
• W4285014503 cites W2145913948 @default.
• W4285014503 cites W2147734798 @default.
• W4285014503 cites W2151567146 @default.
• W4285014503 cites W2154433510 @default.
• W4285014503 cites W2163691729 @default.
• W4285014503 cites W2166969890 @default.
• W4285014503 cites W2225122632 @default.
• W4285014503 cites W2282578582 @default.
• W4285014503 cites W2341996933 @default.
• W4285014503 cites W2425644022 @default.
• W4285014503 cites W2494601841 @default.
• W4285014503 cites W2514658869 @default.
• W4285014503 cites W2514766623 @default.
• W4285014503 cites W2519510391 @default.
• W4285014503 cites W2558262944 @default.
• W4285014503 cites W2587863998 @default.
• W4285014503 cites W2589082299 @default.
• W4285014503 cites W2590664415 @default.
• W4285014503 cites W2602700371 @default.
• W4285014503 cites W2604469807 @default.
• W4285014503 cites W2754041380 @default.
• W4285014503 cites W2770957382 @default.
• W4285014503 cites W2778933123 @default.
• W4285014503 cites W2799375839 @default.
• W4285014503 cites W2885588864 @default.
• W4285014503 cites W2888666511 @default.
• W4285014503 cites W2889521172 @default.
• W4285014503 cites W2894746763 @default.
• W4285014503 cites W2900847413 @default.
• W4285014503 cites W2922550132 @default.
• W4285014503 cites W2948612418 @default.
• W4285014503 cites W2948622224 @default.
• W4285014503 cites W2951522032 @default.
• W4285014503 cites W2978260212 @default.
• W4285014503 cites W2979125147 @default.
• W4285014503 cites W3008572558 @default.
• W4285014503 cites W3010125829 @default.
• W4285014503 cites W3017978130 @default.
• W4285014503 cites W3084829832 @default.
• W4285014503 cites W3110662830 @default.
• W4285014503 cites W3127371223 @default.
• W4285014503 cites W3129305070 @default.
• W4285014503 cites W3173421961 @default.
• W4285014503 cites W3177365549 @default.
• W4285014503 cites W3204819581 @default.
• W4285014503 cites W4206445899 @default.
• W4285014503 cites W4256297099 @default.
• W4285014503 cites W807162506 @default.
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• W4285014503 doi "https://doi.org/10.3389/fendo.2022.927859" @default.
• W4285014503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35898463" @default.
• W4285014503 hasPublicationYear "2022" @default.
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