FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285014611> ?p ?o ?g. }

• W4285014611 abstract "We investigated gluteal (GSAT) and abdominal subcutaneous adipose tissue (ASAT) DNA methylation of FKBP5 in response to a 12-week intervention in African women with obesity, as well as the effect of the rs1360780 single nucleotide polymorphism (SNP) on FKBP5 methylation, gene expression and post-exercise training adaptations in obesity and metabolic related parameters. Exercise (n = 19) participants underwent 12-weeks of supervised aerobic and resistance training while controls (n = 12) continued their usual behaviours. FKBP5 methylation was measured in GSAT and ASAT using pyrosequencing. SNP and gene expression analyses were conducted using quantitative real-time PCR. Exercise training induced FKBP5 hypermethylation at two CpG dinucleotides within intron 7. When stratified based on the rs1360780 SNP, participants with the CT genotype displayed FKBP5 hypermethylation in GSAT (p < 0.05), and ASAT displayed in both CC and CT carriers. CC allele carriers displayed improved cardiorespiratory fitness, insulin sensitivity, gynoid fat mass, and waist circumference (p < 0.05) in response to exercise training, and these parameters were attenuated in women with the CT genotype. These findings provide a basis for future studies in larger cohorts, which should assess whether FKBP5 methylation and/or genetic variants such as the rs1360780 SNP could have a significant impact on responsiveness to exercise interventions." @default.
• W4285014611 created "2022-07-12" @default.
• W4285014611 creator A5028360085 @default.
• W4285014611 creator A5056200629 @default.
• W4285014611 creator A5057746665 @default.
• W4285014611 creator A5058887694 @default.
• W4285014611 creator A5063047880 @default.
• W4285014611 creator A5075451018 @default.
• W4285014611 date "2022-07-11" @default.
• W4285014611 modified "2023-10-14" @default.
• W4285014611 title "A pilot investigation of genetic and epigenetic variation of FKBP5 and response to exercise intervention in African women with obesity" @default.
• W4285014611 cites W1203252705 @default.
• W4285014611 cites W1577577364 @default.
• W4285014611 cites W1603289141 @default.
• W4285014611 cites W1971524892 @default.
• W4285014611 cites W1982882408 @default.
• W4285014611 cites W1983099697 @default.
• W4285014611 cites W1986054293 @default.
• W4285014611 cites W2005070309 @default.
• W4285014611 cites W2007415189 @default.
• W4285014611 cites W2011810796 @default.
• W4285014611 cites W2026786379 @default.
• W4285014611 cites W2036194871 @default.
• W4285014611 cites W2038711271 @default.
• W4285014611 cites W2067096633 @default.
• W4285014611 cites W2084399551 @default.
• W4285014611 cites W2107630787 @default.
• W4285014611 cites W2134800601 @default.
• W4285014611 cites W2136910162 @default.
• W4285014611 cites W2148048066 @default.
• W4285014611 cites W2152690383 @default.
• W4285014611 cites W2160234571 @default.
• W4285014611 cites W2279782005 @default.
• W4285014611 cites W2306482506 @default.
• W4285014611 cites W2336308789 @default.
• W4285014611 cites W2339913955 @default.
• W4285014611 cites W2423560576 @default.
• W4285014611 cites W2490132098 @default.
• W4285014611 cites W2522400862 @default.
• W4285014611 cites W2562345351 @default.
• W4285014611 cites W2587823104 @default.
• W4285014611 cites W2605179369 @default.
• W4285014611 cites W2607031541 @default.
• W4285014611 cites W2724451718 @default.
• W4285014611 cites W2770154204 @default.
• W4285014611 cites W2783125127 @default.
• W4285014611 cites W2793238848 @default.
• W4285014611 cites W2799349612 @default.
• W4285014611 cites W2808930050 @default.
• W4285014611 cites W2912050140 @default.
• W4285014611 cites W2944549000 @default.
• W4285014611 cites W2970064452 @default.
• W4285014611 cites W2982095812 @default.
• W4285014611 cites W2995953306 @default.
• W4285014611 cites W3023533158 @default.
• W4285014611 cites W3037306783 @default.
• W4285014611 cites W3087100578 @default.
• W4285014611 cites W3198500481 @default.
• W4285014611 doi "https://doi.org/10.1038/s41598-022-15678-6" @default.
• W4285014611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35817784" @default.
• W4285014611 hasPublicationYear "2022" @default.
• W4285014611 type Work @default.
• W4285014611 citedByCount "2" @default.
• W4285014611 countsByYear W42850146112023 @default.
• W4285014611 crossrefType "journal-article" @default.
• W4285014611 hasAuthorship W4285014611A5028360085 @default.
• W4285014611 hasAuthorship W4285014611A5056200629 @default.
• W4285014611 hasAuthorship W4285014611A5057746665 @default.
• W4285014611 hasAuthorship W4285014611A5058887694 @default.
• W4285014611 hasAuthorship W4285014611A5063047880 @default.
• W4285014611 hasAuthorship W4285014611A5075451018 @default.
• W4285014611 hasBestOaLocation W42850146111 @default.
• W4285014611 hasConcept C104317684 @default.
• W4285014611 hasConcept C126322002 @default.
• W4285014611 hasConcept C135763542 @default.
• W4285014611 hasConcept C139275648 @default.
• W4285014611 hasConcept C140173407 @default.
• W4285014611 hasConcept C143998085 @default.
• W4285014611 hasConcept C150194340 @default.
• W4285014611 hasConcept C153209595 @default.
• W4285014611 hasConcept C180754005 @default.
• W4285014611 hasConcept C190727270 @default.
• W4285014611 hasConcept C33288867 @default.
• W4285014611 hasConcept C41091548 @default.
• W4285014611 hasConcept C54355233 @default.
• W4285014611 hasConcept C59493245 @default.
• W4285014611 hasConcept C60644358 @default.
• W4285014611 hasConcept C71924100 @default.
• W4285014611 hasConcept C78150878 @default.
• W4285014611 hasConcept C86803240 @default.
• W4285014611 hasConceptScore W4285014611C104317684 @default.
• W4285014611 hasConceptScore W4285014611C126322002 @default.
• W4285014611 hasConceptScore W4285014611C135763542 @default.
• W4285014611 hasConceptScore W4285014611C139275648 @default.
• W4285014611 hasConceptScore W4285014611C140173407 @default.
• W4285014611 hasConceptScore W4285014611C143998085 @default.
• W4285014611 hasConceptScore W4285014611C150194340 @default.
• W4285014611 hasConceptScore W4285014611C153209595 @default.
• W4285014611 hasConceptScore W4285014611C180754005 @default.
• W4285014611 hasConceptScore W4285014611C190727270 @default.

• next