Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285019905> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4285019905 abstract "Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline. In the midbrain, D2-type autoreceptors located on dendrodendritic synapses between dopamine neurons control cell firing through G protein-activated potassium (GIRK) channels. We previously showed that aging disrupts dopamine neuron pacemaker firing in mice, but only in males. Here we show that D2-receptor inhibitory postsynaptic currents (D2-IPSCs) in aged male mice are moderately smaller compared to young males as well as females, regardless of age. Local application of dopamine revealed a reduction in the amplitude of the D2-receptor currents in old males compared to young, pointing to a postsynaptic mechanism that could not be explained by impairment of the GIRK channels or degeneration of the dendritic arbor. Kinetic analysis showed no differences in D2-IPSCs in old versus young mice or between sexes. Potentiation of D2-IPSCs by corticotropin releasing factor (CRF) is also conserved in aging, indicating preservation of plasticity mechanisms. These findings have implications for understanding dopamine transmission in aging in both sexes and could explain in part the increased susceptibility of males to SNc degeneration of dopamine neurons in neurodegenerative disorders such as Parkinson's disease (PD)." @default.
- W4285019905 created "2022-07-12" @default.
- W4285019905 creator A5032715717 @default.
- W4285019905 creator A5034383698 @default.
- W4285019905 creator A5041921053 @default.
- W4285019905 creator A5046912516 @default.
- W4285019905 date "2022-07-11" @default.
- W4285019905 modified "2023-10-15" @default.
- W4285019905 title "Effects of age and sex on dendritic D2 autoreceptor inhibition in substantia nigra dopamine neurons" @default.
- W4285019905 doi "https://doi.org/10.1101/2022.07.10.498507" @default.
- W4285019905 hasPublicationYear "2022" @default.
- W4285019905 type Work @default.
- W4285019905 citedByCount "0" @default.
- W4285019905 crossrefType "posted-content" @default.
- W4285019905 hasAuthorship W4285019905A5032715717 @default.
- W4285019905 hasAuthorship W4285019905A5034383698 @default.
- W4285019905 hasAuthorship W4285019905A5041921053 @default.
- W4285019905 hasAuthorship W4285019905A5046912516 @default.
- W4285019905 hasBestOaLocation W42850199051 @default.
- W4285019905 hasConcept C126322002 @default.
- W4285019905 hasConcept C134018914 @default.
- W4285019905 hasConcept C137183658 @default.
- W4285019905 hasConcept C142652207 @default.
- W4285019905 hasConcept C15744967 @default.
- W4285019905 hasConcept C169760540 @default.
- W4285019905 hasConcept C170493617 @default.
- W4285019905 hasConcept C17077164 @default.
- W4285019905 hasConcept C197341189 @default.
- W4285019905 hasConcept C2775864247 @default.
- W4285019905 hasConcept C2776773494 @default.
- W4285019905 hasConcept C2780938664 @default.
- W4285019905 hasConcept C44208683 @default.
- W4285019905 hasConcept C513476851 @default.
- W4285019905 hasConcept C529278444 @default.
- W4285019905 hasConcept C552161191 @default.
- W4285019905 hasConcept C71924100 @default.
- W4285019905 hasConcept C80631254 @default.
- W4285019905 hasConcept C8439214 @default.
- W4285019905 hasConcept C86803240 @default.
- W4285019905 hasConceptScore W4285019905C126322002 @default.
- W4285019905 hasConceptScore W4285019905C134018914 @default.
- W4285019905 hasConceptScore W4285019905C137183658 @default.
- W4285019905 hasConceptScore W4285019905C142652207 @default.
- W4285019905 hasConceptScore W4285019905C15744967 @default.
- W4285019905 hasConceptScore W4285019905C169760540 @default.
- W4285019905 hasConceptScore W4285019905C170493617 @default.
- W4285019905 hasConceptScore W4285019905C17077164 @default.
- W4285019905 hasConceptScore W4285019905C197341189 @default.
- W4285019905 hasConceptScore W4285019905C2775864247 @default.
- W4285019905 hasConceptScore W4285019905C2776773494 @default.
- W4285019905 hasConceptScore W4285019905C2780938664 @default.
- W4285019905 hasConceptScore W4285019905C44208683 @default.
- W4285019905 hasConceptScore W4285019905C513476851 @default.
- W4285019905 hasConceptScore W4285019905C529278444 @default.
- W4285019905 hasConceptScore W4285019905C552161191 @default.
- W4285019905 hasConceptScore W4285019905C71924100 @default.
- W4285019905 hasConceptScore W4285019905C80631254 @default.
- W4285019905 hasConceptScore W4285019905C8439214 @default.
- W4285019905 hasConceptScore W4285019905C86803240 @default.
- W4285019905 hasLocation W42850199051 @default.
- W4285019905 hasOpenAccess W4285019905 @default.
- W4285019905 hasPrimaryLocation W42850199051 @default.
- W4285019905 hasRelatedWork W1978571393 @default.
- W4285019905 hasRelatedWork W2030644595 @default.
- W4285019905 hasRelatedWork W2087131780 @default.
- W4285019905 hasRelatedWork W2322975839 @default.
- W4285019905 hasRelatedWork W2403478506 @default.
- W4285019905 hasRelatedWork W2414583624 @default.
- W4285019905 hasRelatedWork W2910580599 @default.
- W4285019905 hasRelatedWork W3153299406 @default.
- W4285019905 hasRelatedWork W4285019905 @default.
- W4285019905 hasRelatedWork W4317435093 @default.
- W4285019905 isParatext "false" @default.
- W4285019905 isRetracted "false" @default.
- W4285019905 workType "article" @default.