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- W4285025475 abstract "The first useful enantioselective Pd-catalyzed asymmetric allylic alkylation of α-fluoro-β-ketoesters has been achieved using the Trost family of chiral ligands yielding products in up to 92 % ee. This work provides new insights regarding the typically modest selectivities associated with acyclic α-fluoroenolates and shows experimental evidence that the typically poor levels of enantiocontrol associated with these systems are not necessarily due to the presence of E/Z enolate mixtures. Finally, this methodology allows the easy preparation of useful 3-fluoropiperidine intermediates, and it is demonstrated that these systems are applicable to a range of functionalization reactions leading to new building blocks for the discovery of bioactive products." @default.
- W4285025475 created "2022-07-12" @default.
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- W4285025475 date "2022-08-10" @default.
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- W4285025475 title "Development of an Enantioselective Allylic Alkylation of Acyclic <i>α</i> ‐Fluoro‐ <i>β</i> ‐ketoesters for Asymmetric Synthesis of 3‐Fluoropiperidines" @default.
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- W4285025475 doi "https://doi.org/10.1002/chem.202201595" @default.
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