Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285031808> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4285031808 endingPage "194" @default.
- W4285031808 startingPage "171" @default.
- W4285031808 abstract "Mounting evidence has established that subsets of transposable elements (TEs) function as gene regulatory elements in a cell type- and species-specific manner. Here we describe an in vitro system to ectopically activate TEs using CRISPR-mediated activation (CRISPRa) for functional studies in mouse embryonic stem cells (ESCs). We established a stable mouse CRISPRa ESC line, in which expression of guide RNA enables the activation of TE-derived enhancers and the expression of their adjacent genes. We show an example of ectopic activation of TE-derived enhancers that function in male meiosis, as well as the expression of adjacent germline genes in ESCs. This system can also be applied to functional studies of TEs that are not active in ESCs." @default.
- W4285031808 created "2022-07-12" @default.
- W4285031808 creator A5028700572 @default.
- W4285031808 creator A5044687220 @default.
- W4285031808 creator A5077594621 @default.
- W4285031808 date "2022-01-01" @default.
- W4285031808 modified "2023-09-23" @default.
- W4285031808 title "CRISPR-Mediated Activation of Transposable Elements in Embryonic Stem Cells" @default.
- W4285031808 cites W2046241907 @default.
- W4285031808 cites W2155496026 @default.
- W4285031808 cites W2157663132 @default.
- W4285031808 cites W2163173465 @default.
- W4285031808 cites W2410616080 @default.
- W4285031808 cites W2556763090 @default.
- W4285031808 cites W2803479625 @default.
- W4285031808 cites W2901901698 @default.
- W4285031808 cites W2914573130 @default.
- W4285031808 cites W2973090451 @default.
- W4285031808 cites W3009818641 @default.
- W4285031808 cites W3083432367 @default.
- W4285031808 doi "https://doi.org/10.1007/978-1-0716-2380-0_11" @default.
- W4285031808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35796964" @default.
- W4285031808 hasPublicationYear "2022" @default.
- W4285031808 type Work @default.
- W4285031808 citedByCount "1" @default.
- W4285031808 countsByYear W42850318082023 @default.
- W4285031808 crossrefType "book-chapter" @default.
- W4285031808 hasAuthorship W4285031808A5028700572 @default.
- W4285031808 hasAuthorship W4285031808A5044687220 @default.
- W4285031808 hasAuthorship W4285031808A5077594621 @default.
- W4285031808 hasConcept C104317684 @default.
- W4285031808 hasConcept C109825262 @default.
- W4285031808 hasConcept C111936080 @default.
- W4285031808 hasConcept C141231307 @default.
- W4285031808 hasConcept C145103041 @default.
- W4285031808 hasConcept C150194340 @default.
- W4285031808 hasConcept C165864922 @default.
- W4285031808 hasConcept C28328180 @default.
- W4285031808 hasConcept C4918238 @default.
- W4285031808 hasConcept C54355233 @default.
- W4285031808 hasConcept C86803240 @default.
- W4285031808 hasConcept C95444343 @default.
- W4285031808 hasConcept C97037327 @default.
- W4285031808 hasConcept C98108389 @default.
- W4285031808 hasConceptScore W4285031808C104317684 @default.
- W4285031808 hasConceptScore W4285031808C109825262 @default.
- W4285031808 hasConceptScore W4285031808C111936080 @default.
- W4285031808 hasConceptScore W4285031808C141231307 @default.
- W4285031808 hasConceptScore W4285031808C145103041 @default.
- W4285031808 hasConceptScore W4285031808C150194340 @default.
- W4285031808 hasConceptScore W4285031808C165864922 @default.
- W4285031808 hasConceptScore W4285031808C28328180 @default.
- W4285031808 hasConceptScore W4285031808C4918238 @default.
- W4285031808 hasConceptScore W4285031808C54355233 @default.
- W4285031808 hasConceptScore W4285031808C86803240 @default.
- W4285031808 hasConceptScore W4285031808C95444343 @default.
- W4285031808 hasConceptScore W4285031808C97037327 @default.
- W4285031808 hasConceptScore W4285031808C98108389 @default.
- W4285031808 hasLocation W42850318081 @default.
- W4285031808 hasLocation W42850318082 @default.
- W4285031808 hasOpenAccess W4285031808 @default.
- W4285031808 hasPrimaryLocation W42850318081 @default.
- W4285031808 hasRelatedWork W2028018367 @default.
- W4285031808 hasRelatedWork W2034211922 @default.
- W4285031808 hasRelatedWork W2056573937 @default.
- W4285031808 hasRelatedWork W2132444137 @default.
- W4285031808 hasRelatedWork W2571237645 @default.
- W4285031808 hasRelatedWork W2789592703 @default.
- W4285031808 hasRelatedWork W2951722482 @default.
- W4285031808 hasRelatedWork W3135148909 @default.
- W4285031808 hasRelatedWork W4223420578 @default.
- W4285031808 hasRelatedWork W4285031808 @default.
- W4285031808 isParatext "false" @default.
- W4285031808 isRetracted "false" @default.
- W4285031808 workType "book-chapter" @default.