Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285032203> ?p ?o ?g. }
- W4285032203 abstract "In certain instances, Th17 responses are associated with severe immunopathology. T cell-intrinsic mechanisms that restrict pathogenic effector functions have been described for type 1 and 2 responses but are less well studied for Th17 cells. Here, we report a cell-intrinsic feedback mechanism that controls the pathogenicity of Th17 cells. Th17 cells produce IL-24, which prompts them to secrete IL-10. The IL-10-inducing function of IL-24 is independent of the cell surface receptor of IL-24 on Th17 cells. Rather, IL-24 is recruited to the inner mitochondrial membrane, where it interacts with the NADH dehydrogenase (ubiquinone) 1 α subcomplex subunit 13 (also known as Grim19), a constituent of complex I of the respiratory chain. Together, Grim19 and IL-24 promote the accumulation of STAT3 in the mitochondrial compartment. We propose that IL-24-guided mitochondrial STAT3 constitutes a rheostat to blunt extensive STAT3 deflections in the nucleus, which might then contribute to a robust IL-10 response in Th17 cells and a restriction of immunopathology in experimental autoimmune encephalomyelitis." @default.
- W4285032203 created "2022-07-12" @default.
- W4285032203 creator A5012083757 @default.
- W4285032203 creator A5019776833 @default.
- W4285032203 creator A5021435396 @default.
- W4285032203 creator A5037435546 @default.
- W4285032203 creator A5037734353 @default.
- W4285032203 creator A5040433354 @default.
- W4285032203 creator A5040459908 @default.
- W4285032203 creator A5048801608 @default.
- W4285032203 creator A5052717754 @default.
- W4285032203 creator A5065829916 @default.
- W4285032203 creator A5067928852 @default.
- W4285032203 creator A5068525379 @default.
- W4285032203 creator A5079344825 @default.
- W4285032203 creator A5082231210 @default.
- W4285032203 date "2022-07-12" @default.
- W4285032203 modified "2023-10-14" @default.
- W4285032203 title "IL-24 intrinsically regulates Th17 cell pathogenicity in mice" @default.
- W4285032203 cites W1534542499 @default.
- W4285032203 cites W1627854532 @default.
- W4285032203 cites W1889765774 @default.
- W4285032203 cites W1963632824 @default.
- W4285032203 cites W1966159303 @default.
- W4285032203 cites W1966747379 @default.
- W4285032203 cites W1971249359 @default.
- W4285032203 cites W1973603971 @default.
- W4285032203 cites W1975187768 @default.
- W4285032203 cites W1987944461 @default.
- W4285032203 cites W1989659809 @default.
- W4285032203 cites W1993273784 @default.
- W4285032203 cites W1993764727 @default.
- W4285032203 cites W1995957006 @default.
- W4285032203 cites W1999059713 @default.
- W4285032203 cites W2012733121 @default.
- W4285032203 cites W2015347941 @default.
- W4285032203 cites W2015559526 @default.
- W4285032203 cites W2023777764 @default.
- W4285032203 cites W2024490058 @default.
- W4285032203 cites W2027253055 @default.
- W4285032203 cites W2042503285 @default.
- W4285032203 cites W2043043717 @default.
- W4285032203 cites W2045651220 @default.
- W4285032203 cites W2054551045 @default.
- W4285032203 cites W2067244501 @default.
- W4285032203 cites W2070804167 @default.
- W4285032203 cites W2073424121 @default.
- W4285032203 cites W2083576842 @default.
- W4285032203 cites W2086510997 @default.
- W4285032203 cites W2098412041 @default.
- W4285032203 cites W2101980928 @default.
- W4285032203 cites W2102158172 @default.
- W4285032203 cites W2102212449 @default.
- W4285032203 cites W2107066107 @default.
- W4285032203 cites W2109029563 @default.
- W4285032203 cites W2114982159 @default.
- W4285032203 cites W2116686907 @default.
- W4285032203 cites W2120389604 @default.
- W4285032203 cites W2122623600 @default.
- W4285032203 cites W2126162679 @default.
- W4285032203 cites W2136097155 @default.
- W4285032203 cites W2144288685 @default.
- W4285032203 cites W2146247267 @default.
- W4285032203 cites W2147450297 @default.
- W4285032203 cites W2148118132 @default.
- W4285032203 cites W2152532651 @default.
- W4285032203 cites W2179438025 @default.
- W4285032203 cites W2209349785 @default.
- W4285032203 cites W2326604351 @default.
- W4285032203 cites W2624897240 @default.
- W4285032203 cites W2890824679 @default.
- W4285032203 cites W2929573126 @default.
- W4285032203 cites W2951951814 @default.
- W4285032203 cites W3043321092 @default.
- W4285032203 cites W3099862724 @default.
- W4285032203 cites W3169398005 @default.
- W4285032203 cites W4232278384 @default.
- W4285032203 doi "https://doi.org/10.1084/jem.20212443" @default.
- W4285032203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35819408" @default.
- W4285032203 hasPublicationYear "2022" @default.
- W4285032203 type Work @default.
- W4285032203 citedByCount "3" @default.
- W4285032203 countsByYear W42850322032022 @default.
- W4285032203 countsByYear W42850322032023 @default.
- W4285032203 crossrefType "journal-article" @default.
- W4285032203 hasAuthorship W4285032203A5012083757 @default.
- W4285032203 hasAuthorship W4285032203A5019776833 @default.
- W4285032203 hasAuthorship W4285032203A5021435396 @default.
- W4285032203 hasAuthorship W4285032203A5037435546 @default.
- W4285032203 hasAuthorship W4285032203A5037734353 @default.
- W4285032203 hasAuthorship W4285032203A5040433354 @default.
- W4285032203 hasAuthorship W4285032203A5040459908 @default.
- W4285032203 hasAuthorship W4285032203A5048801608 @default.
- W4285032203 hasAuthorship W4285032203A5052717754 @default.
- W4285032203 hasAuthorship W4285032203A5065829916 @default.
- W4285032203 hasAuthorship W4285032203A5067928852 @default.
- W4285032203 hasAuthorship W4285032203A5068525379 @default.
- W4285032203 hasAuthorship W4285032203A5079344825 @default.
- W4285032203 hasAuthorship W4285032203A5082231210 @default.
- W4285032203 hasBestOaLocation W42850322031 @default.