FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285036265> ?p ?o ?g. }

• W4285036265 abstract "This is a multicentre prospective randomised controlled trial for patients with 3 or more resectable pulmonary metastases from colorectal carcinoma. The study investigates the effects of pulmonary metastasectomy in addition to standard medical treatment in comparison to standard medical treatment plus possible local ablative measures such as SBRT. This trial is intended to demonstrate an overall survival difference in the group undergoing pulmonary metastasectomy. Further secondary and exploratory endpoints include quality of life (EORTC QLQ-C30, QLQ-CR29 and QLQ-LC29 questionnaires), progression-free survival and impact of mutational status. Due to the heterogeneity and complexity of the disease and treatment trajectories in metastasised colorectal cancer, well powered trials have been very challenging to design and execute. The goal of this study is to create a setting which allows treatment as close to the real life conditions as possible but under well standardised conditions. Based on previous trials, in which patient recruitment in the given setting hindered successful study completion, we decided to (1) restrict inclusion to patients with 3 or more metastases (since in case of lesser, surgery will probably be the preferred option) and (2) allow for real world standard of care (SOC) treatment options before and after randomisation including watchful waiting (as opposed to a predefined treatment protocol) and (3) possibility that patient can receive SOC externally (to reduce patient burden). Moreover, we chose to stipulate 12 weeks of systemic treatment prior to possible resection to further standardize treatment response and disease course over a certain period of time. Hence, included patients will be in the disease state of oligopersistence rather than primary oligometastatic. The trial was registered in the German Clinical Trials Register (DRKS-No.: DRKS00024727)." @default.
• W4285036265 created "2022-07-12" @default.
• W4285036265 creator A5000073123 @default.
• W4285036265 creator A5001374436 @default.
• W4285036265 creator A5010473072 @default.
• W4285036265 creator A5013636749 @default.
• W4285036265 creator A5016475093 @default.
• W4285036265 creator A5016975904 @default.
• W4285036265 creator A5018008065 @default.
• W4285036265 creator A5079400405 @default.
• W4285036265 date "2022-07-11" @default.
• W4285036265 modified "2023-10-14" @default.
• W4285036265 title "Study Protocol for a Randomised Controlled Trial on Pulmonary Metastasectomy vs. Standard of Care in Colorectal Cancer Patients With ≥ 3 Lung Metastases (PUCC-Trial)" @default.
• W4285036265 cites W1903641552 @default.
• W4285036265 cites W1976809522 @default.
• W4285036265 cites W2005348280 @default.
• W4285036265 cites W2032979895 @default.
• W4285036265 cites W2103789431 @default.
• W4285036265 cites W2122983648 @default.
• W4285036265 cites W2467054908 @default.
• W4285036265 cites W2531203326 @default.
• W4285036265 cites W2534249763 @default.
• W4285036265 cites W2536769127 @default.
• W4285036265 cites W2596956169 @default.
• W4285036265 cites W2608738563 @default.
• W4285036265 cites W2609243345 @default.
• W4285036265 cites W2620831551 @default.
• W4285036265 cites W2761351587 @default.
• W4285036265 cites W2789249651 @default.
• W4285036265 cites W2804624504 @default.
• W4285036265 cites W2806195669 @default.
• W4285036265 cites W2939770857 @default.
• W4285036265 cites W2970568284 @default.
• W4285036265 cites W3022251390 @default.
• W4285036265 cites W3146206074 @default.
• W4285036265 cites W3172434452 @default.
• W4285036265 doi "https://doi.org/10.3389/fonc.2022.913896" @default.
• W4285036265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35898865" @default.
• W4285036265 hasPublicationYear "2022" @default.
• W4285036265 type Work @default.
• W4285036265 citedByCount "1" @default.
• W4285036265 countsByYear W42850362652023 @default.
• W4285036265 crossrefType "journal-article" @default.
• W4285036265 hasAuthorship W4285036265A5000073123 @default.
• W4285036265 hasAuthorship W4285036265A5001374436 @default.
• W4285036265 hasAuthorship W4285036265A5010473072 @default.
• W4285036265 hasAuthorship W4285036265A5013636749 @default.
• W4285036265 hasAuthorship W4285036265A5016475093 @default.
• W4285036265 hasAuthorship W4285036265A5016975904 @default.
• W4285036265 hasAuthorship W4285036265A5018008065 @default.
• W4285036265 hasAuthorship W4285036265A5079400405 @default.
• W4285036265 hasBestOaLocation W42850362651 @default.
• W4285036265 hasConcept C121608353 @default.
• W4285036265 hasConcept C126322002 @default.
• W4285036265 hasConcept C141071460 @default.
• W4285036265 hasConcept C142724271 @default.
• W4285036265 hasConcept C143998085 @default.
• W4285036265 hasConcept C159110408 @default.
• W4285036265 hasConcept C168563851 @default.
• W4285036265 hasConcept C1862650 @default.
• W4285036265 hasConcept C203092338 @default.
• W4285036265 hasConcept C204787440 @default.
• W4285036265 hasConcept C2776141087 @default.
• W4285036265 hasConcept C2776256026 @default.
• W4285036265 hasConcept C2778601017 @default.
• W4285036265 hasConcept C2779951463 @default.
• W4285036265 hasConcept C2780192828 @default.
• W4285036265 hasConcept C2780385302 @default.
• W4285036265 hasConcept C526805850 @default.
• W4285036265 hasConcept C535046627 @default.
• W4285036265 hasConcept C71924100 @default.
• W4285036265 hasConceptScore W4285036265C121608353 @default.
• W4285036265 hasConceptScore W4285036265C126322002 @default.
• W4285036265 hasConceptScore W4285036265C141071460 @default.
• W4285036265 hasConceptScore W4285036265C142724271 @default.
• W4285036265 hasConceptScore W4285036265C143998085 @default.
• W4285036265 hasConceptScore W4285036265C159110408 @default.
• W4285036265 hasConceptScore W4285036265C168563851 @default.
• W4285036265 hasConceptScore W4285036265C1862650 @default.
• W4285036265 hasConceptScore W4285036265C203092338 @default.
• W4285036265 hasConceptScore W4285036265C204787440 @default.
• W4285036265 hasConceptScore W4285036265C2776141087 @default.
• W4285036265 hasConceptScore W4285036265C2776256026 @default.
• W4285036265 hasConceptScore W4285036265C2778601017 @default.
• W4285036265 hasConceptScore W4285036265C2779951463 @default.
• W4285036265 hasConceptScore W4285036265C2780192828 @default.
• W4285036265 hasConceptScore W4285036265C2780385302 @default.
• W4285036265 hasConceptScore W4285036265C526805850 @default.
• W4285036265 hasConceptScore W4285036265C535046627 @default.
• W4285036265 hasConceptScore W4285036265C71924100 @default.
• W4285036265 hasFunder F4320320879 @default.
• W4285036265 hasLocation W42850362651 @default.
• W4285036265 hasLocation W42850362652 @default.
• W4285036265 hasLocation W42850362653 @default.
• W4285036265 hasLocation W42850362654 @default.
• W4285036265 hasOpenAccess W4285036265 @default.
• W4285036265 hasPrimaryLocation W42850362651 @default.
• W4285036265 hasRelatedWork W2017187888 @default.
• W4285036265 hasRelatedWork W2030552935 @default.
• W4285036265 hasRelatedWork W2037726858 @default.

• next