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• W4285038687 abstract "Significance: Nutraceuticals are ingested for health benefits, in addition to their general nutritional value. These dietary supplements have become increasingly popular since the late 20th century and they are a rapidly expanding global industry approaching a half-trillion U.S. dollars annually. Many nutraceuticals are promulgated as potent antioxidants. Recent Advances: Experimental support for the efficacy of nutraceuticals has lagged behind anecdotal exuberance. However, accumulating epidemiological evidence and recent, well-controlled clinical trials are beginning to support earlier animal and in vitro studies. Although still somewhat limited, encouraging results have been suggested in essentially all organ systems and against a wide range of pathophysiological conditions. Critical Issues: Health benefits of “antioxidant” nutraceuticals are largely attributed to their ability to scavenge oxidants. This has been criticized based on several factors, including limited bioavailability, short tissue retention time, and the preponderance of endogenous antioxidants. Recent attention has turned to nutraceutical activation of downstream antioxidant systems, especially the Keap1/Nrf2 (Kelch like ECH associated protein 1/nuclear factor erythroid 2-related factor 2) axis. The question now becomes, how do nutraceuticals activate this axis? Future Directions: Reactive sulfur species (RSS), including hydrogen sulfide (H2S) and its metabolites, are potent activators of the Keap1/Nrf2 axis and avid scavengers of reactive oxygen species. Evidence is beginning to accumulate that a variety of nutraceuticals increase cellular RSS by directly providing RSS in the diet, or through a number of catalytic mechanisms that increase endogenous RSS production. We propose that nutraceutical-specific targeting of RSS metabolism will lead to the design and development of even more efficacious antioxidant therapeutic strategies. Antioxid. Redox Signal. 38, 68–94." @default.
• W4285038687 created "2022-07-12" @default.
• W4285038687 creator A5008260956 @default.
• W4285038687 creator A5054617879 @default.
• W4285038687 creator A5069935336 @default.
• W4285038687 creator A5081351514 @default.
• W4285038687 date "2023-01-01" @default.
• W4285038687 modified "2023-10-18" @default.
• W4285038687 title "The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling" @default.
• W4285038687 cites W1484633880 @default.
• W4285038687 cites W1512824421 @default.
• W4285038687 cites W1525444530 @default.
• W4285038687 cites W1548494899 @default.
• W4285038687 cites W1564875712 @default.
• W4285038687 cites W1638584560 @default.
• W4285038687 cites W1750690213 @default.
• W4285038687 cites W1796841535 @default.
• W4285038687 cites W1903120836 @default.
• W4285038687 cites W1965696818 @default.
• W4285038687 cites W1965970124 @default.
• W4285038687 cites W1967006697 @default.
• W4285038687 cites W1967315269 @default.
• W4285038687 cites W1968883331 @default.
• W4285038687 cites W1971732805 @default.
• W4285038687 cites W1972975967 @default.
• W4285038687 cites W1973691088 @default.
• W4285038687 cites W1976539175 @default.
• W4285038687 cites W1978042177 @default.
• W4285038687 cites W1978772332 @default.
• W4285038687 cites W1979209619 @default.
• W4285038687 cites W1980021465 @default.
• W4285038687 cites W1982522900 @default.
• W4285038687 cites W1982877190 @default.
• W4285038687 cites W1982895791 @default.
• W4285038687 cites W1983016535 @default.
• W4285038687 cites W1983338479 @default.
• W4285038687 cites W1983420533 @default.
• W4285038687 cites W1984096704 @default.
• W4285038687 cites W1989094996 @default.
• W4285038687 cites W1989603202 @default.
• W4285038687 cites W1991718538 @default.
• W4285038687 cites W1992670283 @default.
• W4285038687 cites W1994133951 @default.
• W4285038687 cites W1995890978 @default.
• W4285038687 cites W1999972814 @default.
• W4285038687 cites W2000732112 @default.
• W4285038687 cites W2003957081 @default.
• W4285038687 cites W2005118820 @default.
• W4285038687 cites W2005948082 @default.
• W4285038687 cites W2006242918 @default.
• W4285038687 cites W2006452232 @default.
• W4285038687 cites W2017119076 @default.
• W4285038687 cites W2017521727 @default.
• W4285038687 cites W2017857953 @default.
• W4285038687 cites W2018839263 @default.
• W4285038687 cites W2020428948 @default.
• W4285038687 cites W2020525465 @default.
• W4285038687 cites W2020599071 @default.
• W4285038687 cites W2020716000 @default.
• W4285038687 cites W2023004426 @default.
• W4285038687 cites W2025131012 @default.
• W4285038687 cites W2025657346 @default.
• W4285038687 cites W2033007699 @default.
• W4285038687 cites W2034116552 @default.
• W4285038687 cites W2034352676 @default.
• W4285038687 cites W2038600558 @default.
• W4285038687 cites W2039171882 @default.
• W4285038687 cites W2039507504 @default.
• W4285038687 cites W2040448986 @default.
• W4285038687 cites W2043847504 @default.
• W4285038687 cites W2046525105 @default.
• W4285038687 cites W2046695863 @default.
• W4285038687 cites W2048924096 @default.
• W4285038687 cites W2055240012 @default.
• W4285038687 cites W2060580528 @default.
• W4285038687 cites W2063207603 @default.
• W4285038687 cites W2065477024 @default.
• W4285038687 cites W2065898821 @default.
• W4285038687 cites W2067266295 @default.
• W4285038687 cites W2071456480 @default.
• W4285038687 cites W2077168519 @default.
• W4285038687 cites W2077792640 @default.
• W4285038687 cites W2078668912 @default.
• W4285038687 cites W2080304600 @default.
• W4285038687 cites W2080361823 @default.
• W4285038687 cites W2080883259 @default.
• W4285038687 cites W2083177668 @default.
• W4285038687 cites W2084644507 @default.
• W4285038687 cites W2085373975 @default.
• W4285038687 cites W2090205085 @default.
• W4285038687 cites W2095096262 @default.
• W4285038687 cites W2095142150 @default.
• W4285038687 cites W2098865088 @default.
• W4285038687 cites W2099829545 @default.
• W4285038687 cites W2100565760 @default.
• W4285038687 cites W2101358878 @default.
• W4285038687 cites W2111822142 @default.
• W4285038687 cites W2112861506 @default.

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