Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285040877> ?p ?o ?g. }
- W4285040877 abstract "With the increased demand for safe and sustainable alternatives to growth promoting antibiotics in the livestock industry, oregano essential oils (OEO) and Lactobacillus reuteri (LR) have been examined as alternatives to antibiotics for growth promotion and to improve animal health and performance. However, the mechanism underlying the OEO and LR mediation of sheep growth remains unknown. In this study, 16S rRNA gene sequencing and untargeted metabolomics were used to determine the role of the gut microbiota in the growth improvements observed. The potential modulating roles of intestinal microbial metabolites of OEO and LR to intestinal health were systematically explored as well. It was observed that both OEO and LR had greater average daily gain (ADG) and lower F/G ratio. Furthermore, OEO also appeared to have produced a greater amylase enzyme activity and mucin gene expression in the jejunal mucosa. It was also observed that OEO reduced serum IL-2 and TNF-β as well as mRNA levels of NF-κB p65 , toll-like receptor-4 ( TLR-4 ), and IL-6 in the jejunal mucosa. Moreover, dietary OEO supplementation increased the abundances of Ruminococcus , Bifidobacterium and Enterococcus , while the relative abundances of Succiniclasticum , Marvinbryantia and Streptococcus were enriched in LR group. Spearman’s correlation analysis revealed that the abundances of Bifidobacterium , Ruminococcus and Enterococcus were positively correlated with the mRNA expression of mucins. Moreover, the relative abundance of Enterococcus was positively correlated with amylase activity. Metabolomics analysis indicated that OEO and LR increased the levels of indole acetaldehyde and indole-3-acetic acid through the tryptophan metabolism pathway. It was observed that LR also decreased the inflammatory metabolites including tryptamine and 5-hydroxyindole-3-acetic acid. Collectively, these results suggested that OEO exerted a beneficial effect on growth performance and the mucosal barrier, affected tryptophan metabolism and improved the intestinal microbiota of sheep." @default.
- W4285040877 created "2022-07-13" @default.
- W4285040877 creator A5018863416 @default.
- W4285040877 creator A5020446394 @default.
- W4285040877 creator A5021199807 @default.
- W4285040877 creator A5030064573 @default.
- W4285040877 creator A5036320219 @default.
- W4285040877 creator A5037063981 @default.
- W4285040877 creator A5040084336 @default.
- W4285040877 creator A5042438142 @default.
- W4285040877 creator A5043619069 @default.
- W4285040877 creator A5066938352 @default.
- W4285040877 creator A5076149365 @default.
- W4285040877 creator A5078466519 @default.
- W4285040877 creator A5079668636 @default.
- W4285040877 date "2022-07-12" @default.
- W4285040877 modified "2023-10-18" @default.
- W4285040877 title "Oregano Essential Oils Mediated Intestinal Microbiota and Metabolites and Improved Growth Performance and Intestinal Barrier Function in Sheep" @default.
- W4285040877 cites W1518824183 @default.
- W4285040877 cites W1918509014 @default.
- W4285040877 cites W1968434240 @default.
- W4285040877 cites W1970104634 @default.
- W4285040877 cites W1973734123 @default.
- W4285040877 cites W1974477809 @default.
- W4285040877 cites W1987711899 @default.
- W4285040877 cites W1989950165 @default.
- W4285040877 cites W1990378571 @default.
- W4285040877 cites W1999376421 @default.
- W4285040877 cites W2001307702 @default.
- W4285040877 cites W2011848880 @default.
- W4285040877 cites W2019165418 @default.
- W4285040877 cites W2024599226 @default.
- W4285040877 cites W2025879035 @default.
- W4285040877 cites W2026582178 @default.
- W4285040877 cites W2040556005 @default.
- W4285040877 cites W2048929455 @default.
- W4285040877 cites W2059885411 @default.
- W4285040877 cites W2063856799 @default.
- W4285040877 cites W2068387572 @default.
- W4285040877 cites W2078351533 @default.
- W4285040877 cites W2078580154 @default.
- W4285040877 cites W2093829386 @default.
- W4285040877 cites W2097094559 @default.
- W4285040877 cites W2103038927 @default.
- W4285040877 cites W2103561589 @default.
- W4285040877 cites W2107277218 @default.
- W4285040877 cites W2126295648 @default.
- W4285040877 cites W2134292086 @default.
- W4285040877 cites W2139072343 @default.
- W4285040877 cites W2145189896 @default.
- W4285040877 cites W2157107905 @default.
- W4285040877 cites W2163031667 @default.
- W4285040877 cites W2192080449 @default.
- W4285040877 cites W2266871990 @default.
- W4285040877 cites W2322297301 @default.
- W4285040877 cites W2329062174 @default.
- W4285040877 cites W2345991090 @default.
- W4285040877 cites W2346752870 @default.
- W4285040877 cites W2401404581 @default.
- W4285040877 cites W2551208740 @default.
- W4285040877 cites W2619070618 @default.
- W4285040877 cites W2734970077 @default.
- W4285040877 cites W2741282769 @default.
- W4285040877 cites W2742482801 @default.
- W4285040877 cites W2743071411 @default.
- W4285040877 cites W2744824945 @default.
- W4285040877 cites W2766449141 @default.
- W4285040877 cites W2777816467 @default.
- W4285040877 cites W2780398151 @default.
- W4285040877 cites W2794344015 @default.
- W4285040877 cites W2807927929 @default.
- W4285040877 cites W2889310917 @default.
- W4285040877 cites W2945672792 @default.
- W4285040877 cites W2949775839 @default.
- W4285040877 cites W2951912016 @default.
- W4285040877 cites W3009498704 @default.
- W4285040877 cites W3014252360 @default.
- W4285040877 cites W3019226949 @default.
- W4285040877 cites W3028433077 @default.
- W4285040877 cites W3081548621 @default.
- W4285040877 cites W3092580207 @default.
- W4285040877 cites W3095845746 @default.
- W4285040877 cites W3100133667 @default.
- W4285040877 cites W3102502550 @default.
- W4285040877 cites W3119559423 @default.
- W4285040877 cites W3121897568 @default.
- W4285040877 cites W3126174938 @default.
- W4285040877 cites W3131544732 @default.
- W4285040877 cites W3133399234 @default.
- W4285040877 cites W3133873644 @default.
- W4285040877 cites W3144004177 @default.
- W4285040877 cites W3155230944 @default.
- W4285040877 cites W3158610768 @default.
- W4285040877 cites W3159210066 @default.
- W4285040877 cites W3196299003 @default.
- W4285040877 cites W3196726647 @default.
- W4285040877 cites W3199191466 @default.
- W4285040877 cites W4220726795 @default.
- W4285040877 doi "https://doi.org/10.3389/fimmu.2022.908015" @default.
- W4285040877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35903106" @default.