Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285041350> ?p ?o ?g. }
- W4285041350 endingPage "742" @default.
- W4285041350 startingPage "735" @default.
- W4285041350 abstract "The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion. Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that bind to all human-infecting coronavirus spike proteins from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune donors. These mAbs recognize the fusion peptide and acquire affinity and breadth through somatic mutations. Despite targeting a conserved motif, only some mAbs show broad neutralizing activity in vitro against alpha- and betacoronaviruses, including animal coronaviruses WIV-1 and PDF-2180. Two selected mAbs also neutralize Omicron BA.1 and BA.2 authentic viruses and reduce viral burden and pathology in vivo. Structural and functional analyses showed that the fusion peptide–specific mAbs bound with different modalities to a cryptic epitope hidden in prefusion stabilized spike, which became exposed upon binding of angiotensin-converting enzyme 2 (ACE2) or ACE2-mimicking mAbs." @default.
- W4285041350 created "2022-07-13" @default.
- W4285041350 creator A5002409017 @default.
- W4285041350 creator A5006902186 @default.
- W4285041350 creator A5006936042 @default.
- W4285041350 creator A5007960584 @default.
- W4285041350 creator A5013371965 @default.
- W4285041350 creator A5021781776 @default.
- W4285041350 creator A5024474695 @default.
- W4285041350 creator A5029519205 @default.
- W4285041350 creator A5029930093 @default.
- W4285041350 creator A5031104787 @default.
- W4285041350 creator A5035683401 @default.
- W4285041350 creator A5038120191 @default.
- W4285041350 creator A5038979662 @default.
- W4285041350 creator A5047171254 @default.
- W4285041350 creator A5050500260 @default.
- W4285041350 creator A5051365729 @default.
- W4285041350 creator A5054158346 @default.
- W4285041350 creator A5055585541 @default.
- W4285041350 creator A5055600834 @default.
- W4285041350 creator A5058313936 @default.
- W4285041350 creator A5059965999 @default.
- W4285041350 creator A5061263271 @default.
- W4285041350 creator A5062839981 @default.
- W4285041350 creator A5064479176 @default.
- W4285041350 creator A5074099434 @default.
- W4285041350 creator A5081079659 @default.
- W4285041350 creator A5083393995 @default.
- W4285041350 creator A5083660414 @default.
- W4285041350 creator A5084976105 @default.
- W4285041350 creator A5085406779 @default.
- W4285041350 creator A5087362989 @default.
- W4285041350 creator A5089010495 @default.
- W4285041350 creator A5091172224 @default.
- W4285041350 date "2022-08-12" @default.
- W4285041350 modified "2023-10-13" @default.
- W4285041350 title "ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies" @default.
- W4285041350 cites W1539248632 @default.
- W4285041350 cites W1816587284 @default.
- W4285041350 cites W1872170079 @default.
- W4285041350 cites W1965435260 @default.
- W4285041350 cites W1965531501 @default.
- W4285041350 cites W1966238900 @default.
- W4285041350 cites W1972143601 @default.
- W4285041350 cites W1978398372 @default.
- W4285041350 cites W1991100887 @default.
- W4285041350 cites W1993577573 @default.
- W4285041350 cites W2002632348 @default.
- W4285041350 cites W2011136801 @default.
- W4285041350 cites W2016991464 @default.
- W4285041350 cites W2027518730 @default.
- W4285041350 cites W2029525307 @default.
- W4285041350 cites W2070086938 @default.
- W4285041350 cites W2076449818 @default.
- W4285041350 cites W2082128938 @default.
- W4285041350 cites W2085887280 @default.
- W4285041350 cites W2107920732 @default.
- W4285041350 cites W2110808180 @default.
- W4285041350 cites W2118274231 @default.
- W4285041350 cites W2119111857 @default.
- W4285041350 cites W2124026197 @default.
- W4285041350 cites W2129678810 @default.
- W4285041350 cites W2130737480 @default.
- W4285041350 cites W2132629607 @default.
- W4285041350 cites W2134972446 @default.
- W4285041350 cites W2145799455 @default.
- W4285041350 cites W2147949826 @default.
- W4285041350 cites W2150633245 @default.
- W4285041350 cites W2154714625 @default.
- W4285041350 cites W2155682217 @default.
- W4285041350 cites W2163135112 @default.
- W4285041350 cites W2163341755 @default.
- W4285041350 cites W2165260654 @default.
- W4285041350 cites W2165918411 @default.
- W4285041350 cites W2178410223 @default.
- W4285041350 cites W2256756668 @default.
- W4285041350 cites W2271364844 @default.
- W4285041350 cites W2380132702 @default.
- W4285041350 cites W2531018947 @default.
- W4285041350 cites W2582422151 @default.
- W4285041350 cites W2734356283 @default.
- W4285041350 cites W2750464792 @default.
- W4285041350 cites W2762161295 @default.
- W4285041350 cites W2793636839 @default.
- W4285041350 cites W2799119185 @default.
- W4285041350 cites W2799725394 @default.
- W4285041350 cites W2801119994 @default.
- W4285041350 cites W2897595682 @default.
- W4285041350 cites W2905349504 @default.
- W4285041350 cites W2915009278 @default.
- W4285041350 cites W2938562409 @default.
- W4285041350 cites W2973457155 @default.
- W4285041350 cites W2975454690 @default.
- W4285041350 cites W2979682945 @default.
- W4285041350 cites W3007220414 @default.
- W4285041350 cites W3007643904 @default.
- W4285041350 cites W3009335299 @default.