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- W4285044197 abstract "<b><i>Introduction:</i></b> Dysregulation of metal ion homeostasis is associated with urothelial carcinogenesis. From a published urinary bladder urothelial carcinoma (UBUC) transcriptome, we identified metallothionein 2A (MT2A) as the most significantly upregulated gene implicated in cancer progression among metal ion binding-related genes. Therefore, we analyzed the association between MT2A expression and clinical significance in our well-characterized cohort of patients with upper tract urothelial carcinoma (UTUC) and UBUC. <b><i>Methods:</i></b> We retrospectively reviewed the clinicopathological characteristics of 295 and 340 patients with UBUC and UTUC, respectively. MT2A expression was assessed using real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry. We further correlated MT2A expression with clinicopathological factors, disease-specific survival (DSS) and metastasis-free survival (MFS) using the Pearson’s χ<sup>2</sup> test, Kaplan-Meier analysis, and multivariate Cox proportional hazards model. <b><i>Results:</i></b> High MT2A expression was significantly associated with aggressive pathological features including high tumor stage, lymph node metastasis, high tumor grade, vascular invasion, and perineural invasion. In the Kaplan-Meier analysis, high MT2A expression was significantly correlated with poor DSS (<i>p</i> < 0.0001) and MFS (<i>p</i> < 0.0001); in the multivariate analysis, it was an independent predictor of CSS (<i>p</i> < 0.001) and MFS (<i>p</i> = 0.001). Gene coexpression analysis demonstrated that MT2A overexpression promotes UC progression through complement activation. <b><i>Conclusion:</i></b> High MT2A expression correlated with aggressive UC features and was an independent predictor of cancer metastasis and patient survival, suggesting its role in risk stratification and decision-making in patients with UTUC and UBUC." @default.
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- W4285044197 date "2022-01-01" @default.
- W4285044197 modified "2023-10-16" @default.
- W4285044197 title "High MT2A Expression Predicts Worse Prognosis in Patients with Urothelial Carcinoma" @default.
- W4285044197 doi "https://doi.org/10.1159/000525743" @default.
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