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- W4285045497 endingPage "673" @default.
- W4285045497 startingPage "657" @default.
- W4285045497 abstract "Schistosomiasis is the second most debilitating neglected tropical disease globally after malaria, with no available therapy to control disease-driven immunopathology. Although schistosomiasis induces a markedly heterogenous immune response, type 2 immunity is the dominating immune response following oviposition. While type 2 immunity has a crucial role in granuloma formation and host survival during the acute stage of disease, its chronic activation can result in tissue scarring, fibrosis, and organ impairment. Here, we discuss recent advances in schistosomiasis, demonstrating how different immune and non-immune cells and signaling pathways are involved in the induction, maintenance, and regulation of type 2 immunity. A better understanding of these immune responses during schistosomiasis is essential to inform the potential development of candidate therapeutic strategies that fine-tune type 2 immunity to ideally modulate schistosomiasis immunopathology." @default.
- W4285045497 created "2022-07-13" @default.
- W4285045497 creator A5006650203 @default.
- W4285045497 creator A5038834213 @default.
- W4285045497 creator A5045068791 @default.
- W4285045497 creator A5048518247 @default.
- W4285045497 creator A5074584534 @default.
- W4285045497 date "2022-08-01" @default.
- W4285045497 modified "2023-10-17" @default.
- W4285045497 title "Type 2 immunity: a two-edged sword in schistosomiasis immunopathology" @default.
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