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- W4285076449 endingPage "1466" @default.
- W4285076449 startingPage "1455" @default.
- W4285076449 abstract "Translocator protein (TSPO, 18 kDa), formerly known as peripheral benzodiazepine receptor, is an evolutionary well-conserved protein located on the outer mitochondrial membrane. TSPO is involved in a variety of fundamental physiological functions and cellular processes. Its expression levels are regulated under many pathological conditions, therefore, TSPO has been proposed as a tool for diagnostic imaging and an attractive therapeutic drug target in the nervous system. Several synthetic TSPO ligands have thus been explored as agonists and antagonists for innovative treatments as neuroprotective and regenerative agents. In this review, we provide state-of-the-art knowledge of TSPO functions in the brain and peripheral nervous system. Particular emphasis is placed on its contribution to important physiological functions such as mitochondrial homeostasis, energy metabolism and steroidogenesis. We also report how it is involved in neuroinflammation, brain injury and diseases of the nervous system." @default.
- W4285076449 created "2022-07-13" @default.
- W4285076449 creator A5055983317 @default.
- W4285076449 creator A5057781231 @default.
- W4285076449 creator A5087330366 @default.
- W4285076449 date "2022-07-12" @default.
- W4285076449 modified "2023-10-15" @default.
- W4285076449 title "The mitochondrial translocator protein (TSPO): a key multifunctional molecule in the nervous system" @default.
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- W4285076449 doi "https://doi.org/10.1042/bcj20220050" @default.
- W4285076449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35819398" @default.
- W4285076449 hasPublicationYear "2022" @default.
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