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- W4285077394 abstract "Hippocampal ripples are transient population bursts that structure cortico-hippocampal communication and play a central role in memory processing. However, the mechanisms controlling ripple initiation in behaving animals remain poorly understood. Here we combine multisite extracellular and whole-cell recordings in awake mice to contrast the brain state and ripple modulation of subthreshold dynamics across hippocampal subfields. We find that entorhinal input to the dentate gyrus (DG) exhibits UP and DOWN dynamics with ripples occurring exclusively in UP states. While elevated cortical input in UP states generates depolarization in DG and CA1, it produces persistent hyperpolarization in CA3 neurons. Furthermore, growing inhibition is evident in CA3 throughout the course of the ripple buildup, while DG and CA1 neurons exhibit depolarization transients 100 ms before and during ripples. These observations highlight the importance of CA3 inhibition for ripple generation, while pre-ripple responses indicate a long and orchestrated ripple initiation process in the awake state." @default.
- W4285077394 created "2022-07-13" @default.
- W4285077394 creator A5025818097 @default.
- W4285077394 creator A5033281863 @default.
- W4285077394 creator A5038492061 @default.
- W4285077394 creator A5060856720 @default.
- W4285077394 date "2022-07-12" @default.
- W4285077394 modified "2023-10-04" @default.
- W4285077394 title "UP-DOWN states and ripples differentially modulate membrane potential dynamics across DG, CA3, and CA1 in awake mice" @default.
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- W4285077394 doi "https://doi.org/10.7554/elife.69596" @default.
- W4285077394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35819409" @default.
- W4285077394 hasPublicationYear "2022" @default.
- W4285077394 type Work @default.
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