Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285079069> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4285079069 endingPage "e0270982" @default.
- W4285079069 startingPage "e0270982" @default.
- W4285079069 abstract "The contribution of Cutibacterium acnes (C. acnes) infection to intervertebral disc degeneration (IDD) and the antibiotic therapy has evoked several controversies in recent years. While some microbiology studies report bacterial disc infection within IDD patients, others attribute the positive results to contamination during prolonged cultures. In addition to the clinical controversy, little was known about the mechanism of C. acnes-caused Modic changes (MCs) if C. acnes was the pathogenic factor.This study aimed to investigate the inflammatory mechanism of MCs induced by different phylotypes of C. acnes in patients with IDD.Specimens from sixty patients undergoing microdiscectomy for disc herniation were included, C. acnes were identified by anaerobic culture, followed by biochemical and PCR-based methods. The identified species of C. acnes were respectively inoculated into the intervertebral discs of rabbits. MRI and histological change were observed. Additionally, we detected MMP expression in the rabbit model using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).Of the 60 cases, 18 (30%) specimens were positive for C. acnes, and we identified 4 of 6 defined phylogroups: IA, IB, II and III. The rabbits that received Type IB or II strains of C. acnes showed significantly decreased T1WI and higher T2WI at eighth weeks, while strain III C. acnes resulted in hypointense signals on both T1WI and T2WI. Histological examination results showed that all of the three types of C. acnes could cause disc degeneration and endplates rupture. Moreover, endplate degeneration induced by type IB or II strains of C. acnes is related with MMP13 expression. Meanwhile, strain III C. acnes might upregulated the level of MMP3.This study suggested that C. acnes is widespread in herniated disc tissues. Different types of C. acnes could induce different MCs by increasing MMP expression." @default.
- W4285079069 created "2022-07-13" @default.
- W4285079069 creator A5031941687 @default.
- W4285079069 creator A5040126153 @default.
- W4285079069 creator A5065590805 @default.
- W4285079069 creator A5076470551 @default.
- W4285079069 creator A5083075916 @default.
- W4285079069 date "2022-07-12" @default.
- W4285079069 modified "2023-09-30" @default.
- W4285079069 title "Different phylotypes of Cutibacterium acnes cause different modic changes in intervertebral disc degeneration" @default.
- W4285079069 cites W1132575004 @default.
- W4285079069 cites W1979843181 @default.
- W4285079069 cites W1981695608 @default.
- W4285079069 cites W1987689482 @default.
- W4285079069 cites W2033571882 @default.
- W4285079069 cites W2037684997 @default.
- W4285079069 cites W2040215497 @default.
- W4285079069 cites W2085216222 @default.
- W4285079069 cites W2114602226 @default.
- W4285079069 cites W2116894164 @default.
- W4285079069 cites W2117995237 @default.
- W4285079069 cites W2119877444 @default.
- W4285079069 cites W2156987533 @default.
- W4285079069 cites W2169810424 @default.
- W4285079069 cites W2268968118 @default.
- W4285079069 cites W2270570738 @default.
- W4285079069 cites W2321042804 @default.
- W4285079069 cites W2332848001 @default.
- W4285079069 cites W2508372568 @default.
- W4285079069 cites W2523089657 @default.
- W4285079069 cites W2595370131 @default.
- W4285079069 cites W2595777170 @default.
- W4285079069 cites W2605239741 @default.
- W4285079069 cites W2616998993 @default.
- W4285079069 cites W2989431907 @default.
- W4285079069 cites W3033958681 @default.
- W4285079069 doi "https://doi.org/10.1371/journal.pone.0270982" @default.
- W4285079069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35819943" @default.
- W4285079069 hasPublicationYear "2022" @default.
- W4285079069 type Work @default.
- W4285079069 citedByCount "3" @default.
- W4285079069 countsByYear W42850790692023 @default.
- W4285079069 crossrefType "journal-article" @default.
- W4285079069 hasAuthorship W4285079069A5031941687 @default.
- W4285079069 hasAuthorship W4285079069A5040126153 @default.
- W4285079069 hasAuthorship W4285079069A5065590805 @default.
- W4285079069 hasAuthorship W4285079069A5076470551 @default.
- W4285079069 hasAuthorship W4285079069A5083075916 @default.
- W4285079069 hasBestOaLocation W42850790691 @default.
- W4285079069 hasConcept C104317684 @default.
- W4285079069 hasConcept C105702510 @default.
- W4285079069 hasConcept C142724271 @default.
- W4285079069 hasConcept C204787440 @default.
- W4285079069 hasConcept C2776339750 @default.
- W4285079069 hasConcept C2777755357 @default.
- W4285079069 hasConcept C2779900937 @default.
- W4285079069 hasConcept C2780907711 @default.
- W4285079069 hasConcept C49105822 @default.
- W4285079069 hasConcept C523546767 @default.
- W4285079069 hasConcept C54355233 @default.
- W4285079069 hasConcept C71924100 @default.
- W4285079069 hasConcept C86803240 @default.
- W4285079069 hasConcept C89423630 @default.
- W4285079069 hasConceptScore W4285079069C104317684 @default.
- W4285079069 hasConceptScore W4285079069C105702510 @default.
- W4285079069 hasConceptScore W4285079069C142724271 @default.
- W4285079069 hasConceptScore W4285079069C204787440 @default.
- W4285079069 hasConceptScore W4285079069C2776339750 @default.
- W4285079069 hasConceptScore W4285079069C2777755357 @default.
- W4285079069 hasConceptScore W4285079069C2779900937 @default.
- W4285079069 hasConceptScore W4285079069C2780907711 @default.
- W4285079069 hasConceptScore W4285079069C49105822 @default.
- W4285079069 hasConceptScore W4285079069C523546767 @default.
- W4285079069 hasConceptScore W4285079069C54355233 @default.
- W4285079069 hasConceptScore W4285079069C71924100 @default.
- W4285079069 hasConceptScore W4285079069C86803240 @default.
- W4285079069 hasConceptScore W4285079069C89423630 @default.
- W4285079069 hasIssue "7" @default.
- W4285079069 hasLocation W42850790691 @default.
- W4285079069 hasLocation W42850790692 @default.
- W4285079069 hasLocation W42850790693 @default.
- W4285079069 hasLocation W42850790694 @default.
- W4285079069 hasOpenAccess W4285079069 @default.
- W4285079069 hasPrimaryLocation W42850790691 @default.
- W4285079069 hasRelatedWork W2268968118 @default.
- W4285079069 hasRelatedWork W2294884544 @default.
- W4285079069 hasRelatedWork W2338638440 @default.
- W4285079069 hasRelatedWork W2551655126 @default.
- W4285079069 hasRelatedWork W2616998993 @default.
- W4285079069 hasRelatedWork W2768370860 @default.
- W4285079069 hasRelatedWork W2921368315 @default.
- W4285079069 hasRelatedWork W2969357880 @default.
- W4285079069 hasRelatedWork W3116021785 @default.
- W4285079069 hasRelatedWork W4318014993 @default.
- W4285079069 hasVolume "17" @default.
- W4285079069 isParatext "false" @default.
- W4285079069 isRetracted "false" @default.
- W4285079069 workType "article" @default.