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- W4285079551 abstract "The evolutionary dynamics of cancer underlie its near boundless potential for therapeutic resistance, representing the greatest challenge in the fight against cancer. These dynamics are driven by the evolving diversity of genetic and epigenetic alterations which translate into signaling dysregulations that underpin cancer hallmarks, including the evasion of growth suppression and the reprograming of metabolism. Pathway entropy is proposed as a measure that can differentiate between tumors and normal tissue as well as shed light on acquired therapeutic resistance. The potential utility of the proposed measure is discussed within the context of lung and colorectal cancers." @default.
- W4285079551 created "2022-07-13" @default.
- W4285079551 creator A5053271609 @default.
- W4285079551 date "2021-12-01" @default.
- W4285079551 modified "2023-09-23" @default.
- W4285079551 title "On Signaling Dysregulation in Cancer" @default.
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- W4285079551 doi "https://doi.org/10.1109/csci54926.2021.00126" @default.
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