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- W4285083244 abstract "Iron is an essential trace element for both humans and bacteria. It plays a vital role in life, such as in redox reactions and electron transport. Strict regulatory mechanisms are necessary to maintain iron homeostasis because both excess and insufficient iron are harmful to life. Competition for iron is a war between humans and bacteria. To grow, reproduce, colonize, and successfully cause infection, pathogens have evolved various mechanisms for iron uptake from humans, principally Fe 3+ -siderophore and Fe 2+ -heme transport systems. Humans have many innate immune mechanisms that regulate the distribution of iron and inhibit bacterial iron uptake to help resist bacterial invasion and colonization. Meanwhile, researchers have invented detection test strips and coupled antibiotics with siderophores to create tools that take advantage of this battle for iron, to help eliminate pathogens. In this review, we summarize bacterial and human iron metabolism, competition for iron between humans and bacteria, siderophore sensors, antibiotics coupled with siderophores, and related phenomena. We also discuss how competition for iron can be used for diagnosis and treatment of infection in the future." @default.
- W4285083244 created "2022-07-14" @default.
- W4285083244 creator A5011859684 @default.
- W4285083244 creator A5013194814 @default.
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- W4285083244 creator A5040039228 @default.
- W4285083244 creator A5067020156 @default.
- W4285083244 creator A5080159973 @default.
- W4285083244 date "2022-07-14" @default.
- W4285083244 modified "2023-10-17" @default.
- W4285083244 title "A zero-sum game or an interactive frame? Iron competition between bacteria and humans in infection war" @default.
- W4285083244 cites W1570067866 @default.
- W4285083244 cites W1963615300 @default.
- W4285083244 cites W1979537717 @default.
- W4285083244 cites W1982245868 @default.
- W4285083244 cites W1986509587 @default.
- W4285083244 cites W1986566018 @default.
- W4285083244 cites W1998000650 @default.
- W4285083244 cites W2000304849 @default.
- W4285083244 cites W2002865102 @default.
- W4285083244 cites W2009759690 @default.
- W4285083244 cites W2012635273 @default.
- W4285083244 cites W2014138367 @default.
- W4285083244 cites W2014723793 @default.
- W4285083244 cites W2016481001 @default.
- W4285083244 cites W2020361557 @default.
- W4285083244 cites W2023289148 @default.
- W4285083244 cites W2029434160 @default.
- W4285083244 cites W2033877425 @default.
- W4285083244 cites W2037434347 @default.
- W4285083244 cites W2041219935 @default.
- W4285083244 cites W2044678473 @default.
- W4285083244 cites W2047220958 @default.
- W4285083244 cites W2047232974 @default.
- W4285083244 cites W2049427340 @default.
- W4285083244 cites W2068119355 @default.
- W4285083244 cites W2069666755 @default.
- W4285083244 cites W2071843084 @default.
- W4285083244 cites W2075632982 @default.
- W4285083244 cites W2076457405 @default.
- W4285083244 cites W2077057020 @default.
- W4285083244 cites W2079251272 @default.
- W4285083244 cites W2082153612 @default.
- W4285083244 cites W2084123221 @default.
- W4285083244 cites W2099143902 @default.
- W4285083244 cites W2105774391 @default.
- W4285083244 cites W2108547072 @default.
- W4285083244 cites W2117087393 @default.
- W4285083244 cites W2123595241 @default.
- W4285083244 cites W2127957332 @default.
- W4285083244 cites W2132196608 @default.
- W4285083244 cites W2147583607 @default.
- W4285083244 cites W2153028868 @default.
- W4285083244 cites W2155799734 @default.
- W4285083244 cites W2156121930 @default.
- W4285083244 cites W2168982702 @default.
- W4285083244 cites W2209878466 @default.
- W4285083244 cites W2217928045 @default.
- W4285083244 cites W2223701580 @default.
- W4285083244 cites W2228380367 @default.
- W4285083244 cites W2318899801 @default.
- W4285083244 cites W2320508761 @default.
- W4285083244 cites W2397483874 @default.
- W4285083244 cites W2466483069 @default.
- W4285083244 cites W2594404901 @default.
- W4285083244 cites W2596432041 @default.
- W4285083244 cites W2606065039 @default.
- W4285083244 cites W2606333588 @default.
- W4285083244 cites W2615194797 @default.
- W4285083244 cites W2624922721 @default.
- W4285083244 cites W2626405715 @default.
- W4285083244 cites W2684900058 @default.
- W4285083244 cites W2740497265 @default.
- W4285083244 cites W2755464816 @default.
- W4285083244 cites W2758445403 @default.
- W4285083244 cites W2765117954 @default.
- W4285083244 cites W2770546211 @default.
- W4285083244 cites W2788094983 @default.
- W4285083244 cites W2792976155 @default.
- W4285083244 cites W2805525679 @default.
- W4285083244 cites W2884248128 @default.
- W4285083244 cites W2905367674 @default.
- W4285083244 cites W2907850175 @default.
- W4285083244 cites W2908921604 @default.
- W4285083244 cites W2912332676 @default.
- W4285083244 cites W2913515660 @default.
- W4285083244 cites W2916265250 @default.
- W4285083244 cites W2919888429 @default.
- W4285083244 cites W2928581379 @default.
- W4285083244 cites W2952665042 @default.
- W4285083244 cites W2968980402 @default.
- W4285083244 cites W2973158135 @default.
- W4285083244 cites W2976479159 @default.
- W4285083244 cites W2978296396 @default.
- W4285083244 cites W2986024416 @default.
- W4285083244 cites W2990378266 @default.
- W4285083244 cites W3021979035 @default.
- W4285083244 cites W3027028445 @default.