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• W4285087012 abstract "Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes GC formation and associated IgG subclass distribution primarily through signaling in cDCs and B cells. Type I IFN signaling in cDCs, distinct from cDC1, stimulates development of separable Tfh and Th1 cell subsets. However, Th cell-derived IFN-γ induces T-bet expression and IgG2c isotype switching in B cells prior to this bifurcation and has no evident effects once GCs and bona fide Tfh cells developed. This pathway acts in synergy with early B cell-intrinsic type I IFN signaling, which reinforces T-bet expression in B cells and leads to a selective amplification of the IgG2c+ GC B cell response. Despite the strong Th1 polarizing effect of type I IFNs, the Tfh cell subset develops into IL-4 producing cells that control the overall magnitude of the GCs and promote generation of IgG1+ GC B cells. Thus, type I IFNs act on B cells and cDCs to drive GC formation and to coordinate IgG subclass distribution through divergent Th1 and Tfh cell-dependent pathways." @default.
• W4285087012 created "2022-07-14" @default.
• W4285087012 creator A5011862057 @default.
• W4285087012 creator A5016853022 @default.
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• W4285087012 creator A5051880704 @default.
• W4285087012 creator A5065934717 @default.
• W4285087012 creator A5082926219 @default.
• W4285087012 date "2022-07-13" @default.
• W4285087012 modified "2023-10-05" @default.
• W4285087012 title "Type I Interferons Promote Germinal Centers Through B Cell Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell Lineages" @default.
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• W4285087012 doi "https://doi.org/10.3389/fimmu.2022.932388" @default.
• W4285087012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35911733" @default.
• W4285087012 hasPublicationYear "2022" @default.
• W4285087012 type Work @default.
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• W4285087012 hasAuthorship W4285087012A5011862057 @default.
• W4285087012 hasAuthorship W4285087012A5016853022 @default.

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