Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285087107> ?p ?o ?g. }
- W4285087107 abstract "Abstract Establishment of zoonotic viruses, causing pandemics like the Spanish flu and Covid-19, requires adaptation to human receptors. Pandemic influenza A viruses (IAV) that crossed the avian-human species barrier switched from binding avian-type α2-3-linked sialic acid (2-3Sia) to human-type 2-6Sia receptors. Here, we show that this specificity switch is however less dichotomous as generally assumed. Binding and entry specificity were compared using mixed synthetic glycan gradients of 2-3Sia and 2-6Sia and by employing a genetically remodeled Sia repertoire on the surface of a Sia-free cell line and on a sialoglycoprotein secreted from these cells. Expression of a range of (mixed) 2-3Sia and 2-6Sia densities shows that non-binding human-type receptors efficiently enhanced avian IAV binding and entry provided the presence of a low density of high affinity avian-type receptors, and vice versa. Considering the heterogeneity of sialoglycan receptors encountered in vivo, hetero-multivalent binding is physiologically relevant and will impact evolutionary pathways leading to host adaptation." @default.
- W4285087107 created "2022-07-14" @default.
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- W4285087107 date "2022-07-13" @default.
- W4285087107 modified "2023-10-18" @default.
- W4285087107 title "Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions" @default.
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- W4285087107 doi "https://doi.org/10.1038/s41467-022-31840-0" @default.
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