Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285087173> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4285087173 abstract "Abstract Objective: To compare the prognostic role regarding gene copy number alteration of MET in schistosomal colorectal cancer (SCRC) and non-schistosomal colorectal cancer (NSCRC). Methods: This retrospective study included 131 SCRC and 207 NSCRC patients, MET status was evaluated by fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) in tissue microarray sections. Results: No significant differences were found in terms of clinical characteristics for SCRC patients and NSCRC patients except for age, where significantly more patients over 60 years old presented SCRC than NSCRC ( P < 0.001). 10.0% of cases were MET FISH-positive (mean ≥ 3 copies/cell). MET protein expression was positive in 60.3% of cases, but was not associated with MET FISH-positive ( P = 0.574). All patients were followed, and the median time was 51.3 months (range, 1.0 – 134.4 months). The prognostic significance of MET FISH-positive was different between SCRC and NSCRC. In SCRC, patients that were MET FISH-positive had significantly shorter survival compared to those that were MET FISH-negative ( P = 0.014). In NSCRC, the overall survival shows a slight trend toward favorable prognosis in association with MET FISH-positive for stage I-II patients ( P = 0.138), yet MET FISH-positive were significantly correlated to adverse survival for stage III-IV patients ( P = 0.015). Conclusions: Increased MET copy number acts as a negative prognostic factor for SCRC, which has bidirectional prognostic significance in NSCRC." @default.
- W4285087173 created "2022-07-14" @default.
- W4285087173 creator A5006743839 @default.
- W4285087173 creator A5018872547 @default.
- W4285087173 creator A5022092259 @default.
- W4285087173 creator A5030535403 @default.
- W4285087173 creator A5035691599 @default.
- W4285087173 creator A5036291554 @default.
- W4285087173 creator A5042669103 @default.
- W4285087173 creator A5063858675 @default.
- W4285087173 date "2022-07-13" @default.
- W4285087173 modified "2023-10-14" @default.
- W4285087173 title "Increased MET Copy Number and its Differing Prognostic Values in Schistosomal and Non-Schistosomal Colorectal Cancers" @default.
- W4285087173 doi "https://doi.org/10.21203/rs.3.rs-1823800/v1" @default.
- W4285087173 hasPublicationYear "2022" @default.
- W4285087173 type Work @default.
- W4285087173 citedByCount "0" @default.
- W4285087173 crossrefType "posted-content" @default.
- W4285087173 hasAuthorship W4285087173A5006743839 @default.
- W4285087173 hasAuthorship W4285087173A5018872547 @default.
- W4285087173 hasAuthorship W4285087173A5022092259 @default.
- W4285087173 hasAuthorship W4285087173A5030535403 @default.
- W4285087173 hasAuthorship W4285087173A5035691599 @default.
- W4285087173 hasAuthorship W4285087173A5036291554 @default.
- W4285087173 hasAuthorship W4285087173A5042669103 @default.
- W4285087173 hasAuthorship W4285087173A5063858675 @default.
- W4285087173 hasBestOaLocation W42850871731 @default.
- W4285087173 hasConcept C104317684 @default.
- W4285087173 hasConcept C121608353 @default.
- W4285087173 hasConcept C126322002 @default.
- W4285087173 hasConcept C143998085 @default.
- W4285087173 hasConcept C146357865 @default.
- W4285087173 hasConcept C151730666 @default.
- W4285087173 hasConcept C167135981 @default.
- W4285087173 hasConcept C204232928 @default.
- W4285087173 hasConcept C2777542201 @default.
- W4285087173 hasConcept C2909208804 @default.
- W4285087173 hasConcept C30481170 @default.
- W4285087173 hasConcept C505870484 @default.
- W4285087173 hasConcept C526805850 @default.
- W4285087173 hasConcept C54355233 @default.
- W4285087173 hasConcept C63363279 @default.
- W4285087173 hasConcept C71924100 @default.
- W4285087173 hasConcept C86803240 @default.
- W4285087173 hasConcept C90924648 @default.
- W4285087173 hasConceptScore W4285087173C104317684 @default.
- W4285087173 hasConceptScore W4285087173C121608353 @default.
- W4285087173 hasConceptScore W4285087173C126322002 @default.
- W4285087173 hasConceptScore W4285087173C143998085 @default.
- W4285087173 hasConceptScore W4285087173C146357865 @default.
- W4285087173 hasConceptScore W4285087173C151730666 @default.
- W4285087173 hasConceptScore W4285087173C167135981 @default.
- W4285087173 hasConceptScore W4285087173C204232928 @default.
- W4285087173 hasConceptScore W4285087173C2777542201 @default.
- W4285087173 hasConceptScore W4285087173C2909208804 @default.
- W4285087173 hasConceptScore W4285087173C30481170 @default.
- W4285087173 hasConceptScore W4285087173C505870484 @default.
- W4285087173 hasConceptScore W4285087173C526805850 @default.
- W4285087173 hasConceptScore W4285087173C54355233 @default.
- W4285087173 hasConceptScore W4285087173C63363279 @default.
- W4285087173 hasConceptScore W4285087173C71924100 @default.
- W4285087173 hasConceptScore W4285087173C86803240 @default.
- W4285087173 hasConceptScore W4285087173C90924648 @default.
- W4285087173 hasLocation W42850871731 @default.
- W4285087173 hasOpenAccess W4285087173 @default.
- W4285087173 hasPrimaryLocation W42850871731 @default.
- W4285087173 hasRelatedWork W1988833950 @default.
- W4285087173 hasRelatedWork W2005164930 @default.
- W4285087173 hasRelatedWork W2073792004 @default.
- W4285087173 hasRelatedWork W2348558296 @default.
- W4285087173 hasRelatedWork W2350902695 @default.
- W4285087173 hasRelatedWork W2366632575 @default.
- W4285087173 hasRelatedWork W3006523215 @default.
- W4285087173 hasRelatedWork W3030181573 @default.
- W4285087173 hasRelatedWork W3032066423 @default.
- W4285087173 hasRelatedWork W4256565872 @default.
- W4285087173 isParatext "false" @default.
- W4285087173 isRetracted "false" @default.
- W4285087173 workType "article" @default.