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- W4285087187 abstract "Introduction Ketamine is gaining renewed interest among healthcare providers in the emergency department (ED) setting due to its novel clinical applications.Areas covered This article provides a comprehensive discussion of ketamine’s pharmacological properties, safety profile, and an overview of current evidence for ketamine in the management of ED patients with acute agitation, pain, depression/suicide ideation.Expert opinion Ketamine is an effective adjunct to opioids, providing greater pain relief than morphine alone. Ketamine (0.1–0.3 mg/kg IV) alone can provide analgesia similar to that of morphine in patients with acute visceral and musculoskeletal pain, as well as for chronic painful conditions (cancer, vaso-occlusive pain crisis associated with sickle cell disease, and in patients with high opioid tolerance and/or opioid dependency). Available literature shows that ketamine (1–2 mg/kg IV or 4–5 mg/kg IM) is a safe, rapid (<5 minutes) and effective tranquilization agent for ED patients with acute agitation. Finally, there is growing evidence that suggests ketamine may have potential utility in the management of patients with self-harm ideation or acute depressive episodes. Intravenous infusion of ketamine (0.5 mg/kg over 40 mins) has been shown to produce an antidepressant effect and decrease in suicidal ideation within 4 hours with effects lasting up to one week." @default.
- W4285087187 created "2022-07-14" @default.
- W4285087187 creator A5025806047 @default.
- W4285087187 creator A5057457560 @default.
- W4285087187 creator A5059414709 @default.
- W4285087187 creator A5078821163 @default.
- W4285087187 date "2022-07-21" @default.
- W4285087187 modified "2023-09-27" @default.
- W4285087187 title "Novel uses of ketamine in the emergency department" @default.
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