Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285087261> ?p ?o ?g. }
- W4285087261 abstract "Non-small-cell lung cancer (NSCLC) is the most common subtype of lung cancer, of which approximate 4% had BRAF activation, with an option for targeted therapy. BRAF activation comprises of V600 and non-V600 mutations, fusion, rearrangement, in-frame deletions, insertions, and co-mutations. In addition, BRAF primary activation and secondary activation presents with different biological phenotypes, medical senses and subsequent treatments. BRAF primary activation plays a critical role in proliferation and metastasis as a driver gene of NSCLC, while secondary activation mediates acquired resistance to other targeted therapy, especially for epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI). Treatment options for different activation of BRAF are diverse. Targeted therapy, especially two-drug combination therapy, is an important option. Besides, immune checkpoint inhibitors (ICIs) would be another option since BRAF activation would be a positive biomarker of tumor response of ICIs therapy. To date, no high level evidences support targeted therapy or immunotherapy as prioritized recommendation. After targeted therapy, the evolution of BRAF includes the activation of the upstream, downstream and bypass pathways of BRAF. In this review, therapeutic modalities and post-therapeutic evolutionary pathways of BRAF are discussed, and future research directions are also provided." @default.
- W4285087261 created "2022-07-14" @default.
- W4285087261 creator A5007648400 @default.
- W4285087261 creator A5031041376 @default.
- W4285087261 creator A5033704842 @default.
- W4285087261 creator A5087757321 @default.
- W4285087261 date "2022-07-13" @default.
- W4285087261 modified "2023-10-03" @default.
- W4285087261 title "The Evolution of BRAF Activation in Non-Small-Cell Lung Cancer" @default.
- W4285087261 cites W1509604487 @default.
- W4285087261 cites W1627238330 @default.
- W4285087261 cites W1764134105 @default.
- W4285087261 cites W1846586690 @default.
- W4285087261 cites W1864827749 @default.
- W4285087261 cites W1940641879 @default.
- W4285087261 cites W1968657935 @default.
- W4285087261 cites W1982330331 @default.
- W4285087261 cites W1982443780 @default.
- W4285087261 cites W1985093953 @default.
- W4285087261 cites W1990011632 @default.
- W4285087261 cites W1996372785 @default.
- W4285087261 cites W1997304962 @default.
- W4285087261 cites W2003867647 @default.
- W4285087261 cites W2009642188 @default.
- W4285087261 cites W2020672661 @default.
- W4285087261 cites W2025130458 @default.
- W4285087261 cites W2027711745 @default.
- W4285087261 cites W2032211985 @default.
- W4285087261 cites W2032487001 @default.
- W4285087261 cites W2032518018 @default.
- W4285087261 cites W2053473615 @default.
- W4285087261 cites W2062289724 @default.
- W4285087261 cites W2067507447 @default.
- W4285087261 cites W2068882576 @default.
- W4285087261 cites W2073190753 @default.
- W4285087261 cites W2081295565 @default.
- W4285087261 cites W2100409527 @default.
- W4285087261 cites W2100614336 @default.
- W4285087261 cites W2105660237 @default.
- W4285087261 cites W2106116393 @default.
- W4285087261 cites W2112276477 @default.
- W4285087261 cites W2113136818 @default.
- W4285087261 cites W2126420121 @default.
- W4285087261 cites W2128327828 @default.
- W4285087261 cites W2137920881 @default.
- W4285087261 cites W2141674733 @default.
- W4285087261 cites W2142020978 @default.
- W4285087261 cites W2146181034 @default.
- W4285087261 cites W2155381255 @default.
- W4285087261 cites W2162044478 @default.
- W4285087261 cites W2163188200 @default.
- W4285087261 cites W2166262263 @default.
- W4285087261 cites W2168420784 @default.
- W4285087261 cites W2176310149 @default.
- W4285087261 cites W2177390620 @default.
- W4285087261 cites W2309935793 @default.
- W4285087261 cites W2335671095 @default.
- W4285087261 cites W2409383155 @default.
- W4285087261 cites W2508840300 @default.
- W4285087261 cites W2517708875 @default.
- W4285087261 cites W2551729158 @default.
- W4285087261 cites W2559746652 @default.
- W4285087261 cites W2571705501 @default.
- W4285087261 cites W2612306689 @default.
- W4285087261 cites W2620519729 @default.
- W4285087261 cites W2739964468 @default.
- W4285087261 cites W2759091821 @default.
- W4285087261 cites W2770873726 @default.
- W4285087261 cites W2773352127 @default.
- W4285087261 cites W2783972794 @default.
- W4285087261 cites W2786037260 @default.
- W4285087261 cites W2789665281 @default.
- W4285087261 cites W2789924745 @default.
- W4285087261 cites W2793780677 @default.
- W4285087261 cites W2793817570 @default.
- W4285087261 cites W2794839416 @default.
- W4285087261 cites W2802291700 @default.
- W4285087261 cites W2802395274 @default.
- W4285087261 cites W2808608845 @default.
- W4285087261 cites W2898537638 @default.
- W4285087261 cites W2900849878 @default.
- W4285087261 cites W2919959132 @default.
- W4285087261 cites W2935682949 @default.
- W4285087261 cites W2937117858 @default.
- W4285087261 cites W2943857365 @default.
- W4285087261 cites W2953511998 @default.
- W4285087261 cites W2969664042 @default.
- W4285087261 cites W2971041600 @default.
- W4285087261 cites W2972398605 @default.
- W4285087261 cites W2975708027 @default.
- W4285087261 cites W2975764786 @default.
- W4285087261 cites W2978999244 @default.
- W4285087261 cites W2979082411 @default.
- W4285087261 cites W2981109881 @default.
- W4285087261 cites W2988591933 @default.
- W4285087261 cites W2989605045 @default.
- W4285087261 cites W2999136960 @default.
- W4285087261 cites W3000445801 @default.
- W4285087261 cites W3006750660 @default.
- W4285087261 cites W3007835695 @default.