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- W4285087335 endingPage "89" @default.
- W4285087335 startingPage "75" @default.
- W4285087335 abstract "Genomic instability is an important driver of ageing. The accumulation of DNA damage is believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction. However, emerging evidence shows that inflammation is another major consequence of DNA damage. Inflammation is a hallmark of ageing and the driver of multiple age-related diseases. Here, we review the evidence linking DNA damage, inflammation and ageing, highlighting how premature ageing syndromes are associated with inflammation. We discuss the mechanisms by which DNA damage induces inflammation, such as through activation of the cGAS-STING axis and NF-κB activation by ATM. The triggers for activation of these signalling cascades are the age-related accumulation of DNA damage, activation of transposons, cellular senescence and the accumulation of persistent R-loops. We also discuss how epigenetic changes triggered by DNA damage can lead to inflammation and ageing via redistribution of heterochromatin factors. Finally, we discuss potential interventions against age-related inflammation." @default.
- W4285087335 created "2022-07-14" @default.
- W4285087335 creator A5011973337 @default.
- W4285087335 creator A5052978985 @default.
- W4285087335 creator A5069057903 @default.
- W4285087335 creator A5077419383 @default.
- W4285087335 date "2022-07-13" @default.
- W4285087335 modified "2023-10-10" @default.
- W4285087335 title "DNA damage and repair in age-related inflammation" @default.
- W4285087335 cites W1412166937 @default.
- W4285087335 cites W1536059425 @default.
- W4285087335 cites W1557728494 @default.
- W4285087335 cites W1673747382 @default.
- W4285087335 cites W1800944583 @default.
- W4285087335 cites W1830488268 @default.
- W4285087335 cites W1869763094 @default.
- W4285087335 cites W1872142865 @default.
- W4285087335 cites W1905278501 @default.
- W4285087335 cites W1953890763 @default.
- W4285087335 cites W1964551999 @default.
- W4285087335 cites W1968245004 @default.
- W4285087335 cites W1969503475 @default.
- W4285087335 cites W1970966311 @default.
- W4285087335 cites W1981148605 @default.
- W4285087335 cites W1982644994 @default.
- W4285087335 cites W1983225716 @default.
- W4285087335 cites W1986635328 @default.
- W4285087335 cites W1987257612 @default.
- W4285087335 cites W1987603976 @default.
- W4285087335 cites W1990493392 @default.
- W4285087335 cites W1998032989 @default.
- W4285087335 cites W2001884031 @default.
- W4285087335 cites W2001961555 @default.
- W4285087335 cites W2003549116 @default.
- W4285087335 cites W2003848438 @default.
- W4285087335 cites W2004314923 @default.
- W4285087335 cites W2005884645 @default.
- W4285087335 cites W2010417927 @default.
- W4285087335 cites W2010794194 @default.
- W4285087335 cites W2012147370 @default.
- W4285087335 cites W2019276374 @default.
- W4285087335 cites W2024209230 @default.
- W4285087335 cites W2027855246 @default.
- W4285087335 cites W2029223147 @default.
- W4285087335 cites W2030173297 @default.
- W4285087335 cites W2035232303 @default.
- W4285087335 cites W2035858672 @default.
- W4285087335 cites W2039508777 @default.
- W4285087335 cites W2040741651 @default.
- W4285087335 cites W2043375872 @default.
- W4285087335 cites W2052152963 @default.
- W4285087335 cites W2054866841 @default.
- W4285087335 cites W2058803210 @default.
- W4285087335 cites W2059173951 @default.
- W4285087335 cites W2059370490 @default.
- W4285087335 cites W2060768223 @default.
- W4285087335 cites W2064802388 @default.
- W4285087335 cites W2065667074 @default.
- W4285087335 cites W2073204556 @default.
- W4285087335 cites W2076835726 @default.
- W4285087335 cites W2077145482 @default.
- W4285087335 cites W2078519775 @default.
- W4285087335 cites W2079674166 @default.
- W4285087335 cites W2081796577 @default.
- W4285087335 cites W2082248803 @default.
- W4285087335 cites W2082402714 @default.
- W4285087335 cites W2082810375 @default.
- W4285087335 cites W2083147016 @default.
- W4285087335 cites W2083439589 @default.
- W4285087335 cites W2083922442 @default.
- W4285087335 cites W2084369408 @default.
- W4285087335 cites W2085350682 @default.
- W4285087335 cites W2090525461 @default.
- W4285087335 cites W2092010310 @default.
- W4285087335 cites W2094807579 @default.
- W4285087335 cites W2094875875 @default.
- W4285087335 cites W2097750604 @default.
- W4285087335 cites W2099610218 @default.
- W4285087335 cites W2101185010 @default.
- W4285087335 cites W2102265131 @default.
- W4285087335 cites W2102904926 @default.
- W4285087335 cites W2103694115 @default.
- W4285087335 cites W2104164098 @default.
- W4285087335 cites W2104301158 @default.
- W4285087335 cites W2106515413 @default.
- W4285087335 cites W2107455041 @default.
- W4285087335 cites W2114280375 @default.
- W4285087335 cites W2114769795 @default.
- W4285087335 cites W2115852450 @default.
- W4285087335 cites W2116054786 @default.
- W4285087335 cites W2121679131 @default.
- W4285087335 cites W2121818828 @default.
- W4285087335 cites W2126525177 @default.
- W4285087335 cites W2127708563 @default.
- W4285087335 cites W2128552624 @default.
- W4285087335 cites W2129899300 @default.
- W4285087335 cites W2130151956 @default.
- W4285087335 cites W2135564059 @default.