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- W4285087365 abstract "T helper type 2 cells (Th2 cells) and group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of asthma, including airway eosinophilic inflammation. ILC2s are activated by epithelial-derived cytokines [interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP)] from airway epithelial cells, leading to the release of high amounts of type 2 cytokines, such as IL-5 and IL-13. ILC2s induce airway inflammation in an antigen-independent manner, and ILC2s are considered to be involved in the pathogenesis of asthma exacerbation. Furthermore, ILC2 activation might also confer steroid resistance. Many recent studies in humans and mice are increasingly demonstrating that the function of ILC2s is regulated not just by epithelial-derived cytokines but by a variety of cytokines and mediators derived from innate immune cells. Furthermore, the biologics targeting these cytokines and/or their receptors have been shown to reduce asthma exacerbations and improve lung function and quality of life in asthmatics. This article reviews the current treatment landscape for type 2 airway inflammation in asthma and discusses the therapeutic potential for targeting ILC2s." @default.
- W4285087365 created "2022-07-14" @default.
- W4285087365 creator A5029799924 @default.
- W4285087365 creator A5031981364 @default.
- W4285087365 creator A5036516013 @default.
- W4285087365 creator A5039527478 @default.
- W4285087365 creator A5054394679 @default.
- W4285087365 creator A5073433163 @default.
- W4285087365 date "2022-07-13" @default.
- W4285087365 modified "2023-10-14" @default.
- W4285087365 title "The Therapeutic Potential for Targeting Group 2 Innate Lymphoid Cells in Asthma" @default.
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