Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285087387> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4285087387 endingPage "1683" @default.
- W4285087387 startingPage "1683" @default.
- W4285087387 abstract "(1) Background: COVID-19-associated pulmonary aspergillosis (CAPA) has worsened the prognosis of patients with pneumonia and acute respiratory distress syndrome admitted to the intensive care unit (ICU). The lack of specific diagnosis criteria is an obstacle to the timely initiation of appropriate antifungal therapy. Tracheal aspirate (TA) has been employed under special pandemic conditions. Galactomannan (GM) antigens are released during active fungal growth. (2) Methods: We proposed the term “CAPA in progress” (CAPA-IP) for diagnosis at an earlier stage by GM testing on TA in a specific population admitted to ICU presenting with clinical deterioration. A GM threshold ≥0.5 was set as the mycological inclusion criterion. This was followed by a pre-emptive short-course antifungal. (3) Results: We prospectively enrolled 200 ICU patients with COVID-19. Of these, 164 patients (82%) initially required invasive mechanical ventilation and GM was tested in TA in 93 patients. A subset of 19 patients (11.5%) fulfilled the CAPA-IP criteria at a median of 9 days after ICU admittance. The median GM value was 3.25 ± 2.82. CAPA-IP cases showed significantly higher ICU mortality [52.6% (10/19) vs. 34.5% (50/145), p = 0.036], as well as a much longer median ICU stay than those with a normal GM index [27 (7–64) vs. 11 (9–81) days, p = 0.008]. All cases were treated with a pre-emptive systemic antifungal for a median time of 19 (3–39) days. (4) Conclusions: CAPA-IP highlights a new real-life early approach in the field of fungal stewardship in ICU programs." @default.
- W4285087387 created "2022-07-14" @default.
- W4285087387 creator A5016193407 @default.
- W4285087387 creator A5019886939 @default.
- W4285087387 creator A5029078164 @default.
- W4285087387 creator A5044487058 @default.
- W4285087387 creator A5057536435 @default.
- W4285087387 creator A5057610852 @default.
- W4285087387 creator A5068754551 @default.
- W4285087387 creator A5076827171 @default.
- W4285087387 creator A5086321435 @default.
- W4285087387 creator A5088741412 @default.
- W4285087387 date "2022-07-13" @default.
- W4285087387 modified "2023-10-18" @default.
- W4285087387 title "“CAPA in Progress”: A New Real-Life Approach for the Management of Critically Ill COVID-19 Patients" @default.
- W4285087387 cites W2039267791 @default.
- W4285087387 cites W2098438303 @default.
- W4285087387 cites W2167423543 @default.
- W4285087387 cites W2470291098 @default.
- W4285087387 cites W2603808360 @default.
- W4285087387 cites W2793884909 @default.
- W4285087387 cites W2809760546 @default.
- W4285087387 cites W3036766665 @default.
- W4285087387 cites W3043778525 @default.
- W4285087387 cites W3046139360 @default.
- W4285087387 cites W3081313246 @default.
- W4285087387 cites W3094363667 @default.
- W4285087387 cites W3104780464 @default.
- W4285087387 cites W3112984291 @default.
- W4285087387 cites W3128752839 @default.
- W4285087387 cites W3131528786 @default.
- W4285087387 cites W3137846599 @default.
- W4285087387 cites W3193623972 @default.
- W4285087387 cites W4220759933 @default.
- W4285087387 doi "https://doi.org/10.3390/biomedicines10071683" @default.
- W4285087387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35884988" @default.
- W4285087387 hasPublicationYear "2022" @default.
- W4285087387 type Work @default.
- W4285087387 citedByCount "0" @default.
- W4285087387 crossrefType "journal-article" @default.
- W4285087387 hasAuthorship W4285087387A5016193407 @default.
- W4285087387 hasAuthorship W4285087387A5019886939 @default.
- W4285087387 hasAuthorship W4285087387A5029078164 @default.
- W4285087387 hasAuthorship W4285087387A5044487058 @default.
- W4285087387 hasAuthorship W4285087387A5057536435 @default.
- W4285087387 hasAuthorship W4285087387A5057610852 @default.
- W4285087387 hasAuthorship W4285087387A5068754551 @default.
- W4285087387 hasAuthorship W4285087387A5076827171 @default.
- W4285087387 hasAuthorship W4285087387A5086321435 @default.
- W4285087387 hasAuthorship W4285087387A5088741412 @default.
- W4285087387 hasBestOaLocation W42850873871 @default.
- W4285087387 hasConcept C126322002 @default.
- W4285087387 hasConcept C177713679 @default.
- W4285087387 hasConcept C203014093 @default.
- W4285087387 hasConcept C2776376669 @default.
- W4285087387 hasConcept C2776391196 @default.
- W4285087387 hasConcept C2777080012 @default.
- W4285087387 hasConcept C2777914695 @default.
- W4285087387 hasConcept C2780347030 @default.
- W4285087387 hasConcept C2908647359 @default.
- W4285087387 hasConcept C71924100 @default.
- W4285087387 hasConcept C99454951 @default.
- W4285087387 hasConceptScore W4285087387C126322002 @default.
- W4285087387 hasConceptScore W4285087387C177713679 @default.
- W4285087387 hasConceptScore W4285087387C203014093 @default.
- W4285087387 hasConceptScore W4285087387C2776376669 @default.
- W4285087387 hasConceptScore W4285087387C2776391196 @default.
- W4285087387 hasConceptScore W4285087387C2777080012 @default.
- W4285087387 hasConceptScore W4285087387C2777914695 @default.
- W4285087387 hasConceptScore W4285087387C2780347030 @default.
- W4285087387 hasConceptScore W4285087387C2908647359 @default.
- W4285087387 hasConceptScore W4285087387C71924100 @default.
- W4285087387 hasConceptScore W4285087387C99454951 @default.
- W4285087387 hasIssue "7" @default.
- W4285087387 hasLocation W42850873871 @default.
- W4285087387 hasLocation W42850873872 @default.
- W4285087387 hasLocation W42850873873 @default.
- W4285087387 hasLocation W42850873874 @default.
- W4285087387 hasOpenAccess W4285087387 @default.
- W4285087387 hasPrimaryLocation W42850873871 @default.
- W4285087387 hasRelatedWork W160291598 @default.
- W4285087387 hasRelatedWork W1651394837 @default.
- W4285087387 hasRelatedWork W1893106798 @default.
- W4285087387 hasRelatedWork W2009263326 @default.
- W4285087387 hasRelatedWork W2093022913 @default.
- W4285087387 hasRelatedWork W2101793730 @default.
- W4285087387 hasRelatedWork W2327883320 @default.
- W4285087387 hasRelatedWork W2335083976 @default.
- W4285087387 hasRelatedWork W3204296811 @default.
- W4285087387 hasRelatedWork W4241379487 @default.
- W4285087387 hasVolume "10" @default.
- W4285087387 isParatext "false" @default.
- W4285087387 isRetracted "false" @default.
- W4285087387 workType "article" @default.