FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285087461> ?p ?o ?g. }

• W4285087461 abstract "Tongue squamous cell carcinoma (TSCC) is a prevalent cancer of the oral cavity. Survival metrics are usually unsatisfactory, even using combined treatment with surgery, radiation, and chemotherapy. Immune checkpoint inhibitors can prolong survival, especially in patients with recurrent or metastatic disease. However, there are few effective biomarkers to provide prognosis and guide immunotherapy. Here, we utilized weighted gene co-expression network analysis to identify the co-expression module and selected the turquoise module for further scrutiny. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed the innate pathways. The findings indicated that cell junction organization, response to topologically incorrect protein, and regulation of cell adhesion pathways may be essential. Eleven crucial predictive genes (PLXNB1, N4BP3, KDELR2, INTS8, PLAU, PPFIBP2, OAF, LMF1, IL34, ZFP3, and MAP7D3) were used to establish a risk model based on Cox and LASSO analyses of The Cancer Genome Atlas and GSE65858 databases (regarding overall survival). Kaplan-Meier analysis and receiver operating characteristic curve suggested that the risk model had better prognostic effectiveness than other clinical traits. Consensus clustering was used to classify TSCC samples into two groups with significantly different survival rates. ESTIMATE and CIBERSORT were used to display the immune landscape of TSCC and indicate the stromal score; specific types of immune cells, including naïve B cells, plasma cells, CD8 T cells, CD4 memory resting and memory activated T cells, follicular helper T cells, and T regulatory cells, may influence the heterogeneous immune microenvironment in TSCC. To further identify hub genes, we downloaded GEO datasets (GSE41613 and GSE31056) and successfully validated the risk model. Two hub genes (PLAU and PPFIBP2) were strongly associated with CD4+ and CD8+ T cells and programmed cell death protein 1 (PD1) and PD-ligand 1." @default.
• W4285087461 created "2022-07-14" @default.
• W4285087461 creator A5014208281 @default.
• W4285087461 creator A5070248614 @default.
• W4285087461 creator A5072498852 @default.
• W4285087461 creator A5076167118 @default.
• W4285087461 creator A5090366405 @default.
• W4285087461 creator A5090997916 @default.
• W4285087461 date "2022-07-13" @default.
• W4285087461 modified "2023-10-14" @default.
• W4285087461 title "An Integrated Analysis of Prognostic Signature and Immune Microenvironment in Tongue Squamous Cell Carcinoma" @default.
• W4285087461 cites W1645587630 @default.
• W4285087461 cites W1966327575 @default.
• W4285087461 cites W1978918505 @default.
• W4285087461 cites W1986079728 @default.
• W4285087461 cites W1994993231 @default.
• W4285087461 cites W2019051236 @default.
• W4285087461 cites W2024362866 @default.
• W4285087461 cites W2045124359 @default.
• W4285087461 cites W2045248401 @default.
• W4285087461 cites W2048657818 @default.
• W4285087461 cites W2061572018 @default.
• W4285087461 cites W2069355079 @default.
• W4285087461 cites W2091135133 @default.
• W4285087461 cites W2112845420 @default.
• W4285087461 cites W2122997780 @default.
• W4285087461 cites W2149668671 @default.
• W4285087461 cites W2166349420 @default.
• W4285087461 cites W2225758346 @default.
• W4285087461 cites W2401455386 @default.
• W4285087461 cites W2523194272 @default.
• W4285087461 cites W2537963082 @default.
• W4285087461 cites W2558570600 @default.
• W4285087461 cites W2569821107 @default.
• W4285087461 cites W2598754329 @default.
• W4285087461 cites W2602907503 @default.
• W4285087461 cites W2711613673 @default.
• W4285087461 cites W2748873969 @default.
• W4285087461 cites W2759097260 @default.
• W4285087461 cites W2762545332 @default.
• W4285087461 cites W2767345554 @default.
• W4285087461 cites W2791482536 @default.
• W4285087461 cites W2883525575 @default.
• W4285087461 cites W2888342869 @default.
• W4285087461 cites W2905098668 @default.
• W4285087461 cites W2953074487 @default.
• W4285087461 cites W2955283109 @default.
• W4285087461 cites W2956551896 @default.
• W4285087461 cites W2986633517 @default.
• W4285087461 cites W2995779974 @default.
• W4285087461 cites W2996118836 @default.
• W4285087461 cites W3080936926 @default.
• W4285087461 cites W3147586197 @default.
• W4285087461 cites W3157558500 @default.
• W4285087461 cites W3217203291 @default.
• W4285087461 cites W4211053702 @default.
• W4285087461 cites W4220686525 @default.
• W4285087461 doi "https://doi.org/10.3389/fonc.2022.891716" @default.
• W4285087461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35912229" @default.
• W4285087461 hasPublicationYear "2022" @default.
• W4285087461 type Work @default.
• W4285087461 citedByCount "2" @default.
• W4285087461 countsByYear W42850874612023 @default.
• W4285087461 crossrefType "journal-article" @default.
• W4285087461 hasAuthorship W4285087461A5014208281 @default.
• W4285087461 hasAuthorship W4285087461A5070248614 @default.
• W4285087461 hasAuthorship W4285087461A5072498852 @default.
• W4285087461 hasAuthorship W4285087461A5076167118 @default.
• W4285087461 hasAuthorship W4285087461A5090366405 @default.
• W4285087461 hasAuthorship W4285087461A5090997916 @default.
• W4285087461 hasBestOaLocation W42850874611 @default.
• W4285087461 hasConcept C104317684 @default.
• W4285087461 hasConcept C121608353 @default.
• W4285087461 hasConcept C126322002 @default.
• W4285087461 hasConcept C143998085 @default.
• W4285087461 hasConcept C150194340 @default.
• W4285087461 hasConcept C152724338 @default.
• W4285087461 hasConcept C162317418 @default.
• W4285087461 hasConcept C167672396 @default.
• W4285087461 hasConcept C16930146 @default.
• W4285087461 hasConcept C203014093 @default.
• W4285087461 hasConcept C2776107976 @default.
• W4285087461 hasConcept C2776530083 @default.
• W4285087461 hasConcept C2776833033 @default.
• W4285087461 hasConcept C2777701055 @default.
• W4285087461 hasConcept C502942594 @default.
• W4285087461 hasConcept C55493867 @default.
• W4285087461 hasConcept C71924100 @default.
• W4285087461 hasConcept C86803240 @default.
• W4285087461 hasConcept C8891405 @default.
• W4285087461 hasConceptScore W4285087461C104317684 @default.
• W4285087461 hasConceptScore W4285087461C121608353 @default.
• W4285087461 hasConceptScore W4285087461C126322002 @default.
• W4285087461 hasConceptScore W4285087461C143998085 @default.
• W4285087461 hasConceptScore W4285087461C150194340 @default.
• W4285087461 hasConceptScore W4285087461C152724338 @default.
• W4285087461 hasConceptScore W4285087461C162317418 @default.
• W4285087461 hasConceptScore W4285087461C167672396 @default.
• W4285087461 hasConceptScore W4285087461C16930146 @default.
• W4285087461 hasConceptScore W4285087461C203014093 @default.

• next