FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285087689> ?p ?o ?g. }

• W4285087689 abstract "Hepatocellular carcinoma (HCC) is a highly aggressive malignancy. Irreversible electroporation (IRE) is an ablative modality that uses high-voltage electrical pulses to permeabilize the cell membrane leading to cell necrosis. Unlike traditional thermal ablation, IRE is hardly affected by the heat-sink effect and can prevent damage of the adjacent vital structures. Nanosecond pulsed electric field (nsPEF) is a new IRE technique using ultra-short pulses (nanosecond duration), can not only penetrate the cell membranes, but also act on the organelles. Sufficient preclinical researches have shown that nsPEF can eliminate HCC without damaging vital organs, and elicit potent anti-tumor immune response.This is the first clinical study to evaluate feasibility, efficacy, and safety of nsPEF for the treatment of HCC, where thermal ablation is unsuitable due to proximity to critical structures.We will conduct an open-labeled, single-arm, prospective, multicenter, and objective performance criteria trial. One hundred and ninety-two patients with HCC, in which the tumor is located immediately (<0.5 cm) adjacent to the portal vein, hepatic veins, bile duct, gastrointestinal tract, or diaphragm, will be enrolled among 4 academic medical centers. The primary outcomes are the rate of complete ablation at 1 month and adverse events. Secondary outcomes include technical success, technique efficacy, nsPEF procedural characteristics, local tumor progression, and local progression-free survival.The trial will be conducted according to the ethical principles of the Declaration of Helsinki and has been approved by the ethics committee of all participating centers. The results of this study will be published in peer-reviewed scientific journals and presented at relevant academic conferences.This study is the Phase 1 clinical trial to evaluate the efficacy and safety of nsPEF in patients with HCC at high-risk locations where thermal ablation is contra-indicated. The results may expand the options and offer an alternative therapy for HCC.ClinicalTrials.gov, identifier NCT04309747." @default.
• W4285087689 created "2022-07-14" @default.
• W4285087689 creator A5003281764 @default.
• W4285087689 creator A5008047814 @default.
• W4285087689 creator A5010137279 @default.
• W4285087689 creator A5016874780 @default.
• W4285087689 creator A5024944236 @default.
• W4285087689 creator A5025283381 @default.
• W4285087689 creator A5036565708 @default.
• W4285087689 creator A5039615242 @default.
• W4285087689 creator A5088539918 @default.
• W4285087689 date "2022-07-13" @default.
• W4285087689 modified "2023-10-12" @default.
• W4285087689 title "The Safety and Efficacy of Nanosecond Pulsed Electric Field in Patients With Hepatocellular Carcinoma: A Prospective Phase 1 Clinical Study Protocol" @default.
• W4285087689 cites W1889020408 @default.
• W4285087689 cites W1963943534 @default.
• W4285087689 cites W1977540990 @default.
• W4285087689 cites W1980171286 @default.
• W4285087689 cites W2003802737 @default.
• W4285087689 cites W2008995080 @default.
• W4285087689 cites W2010283945 @default.
• W4285087689 cites W2052639082 @default.
• W4285087689 cites W2082549948 @default.
• W4285087689 cites W2096759906 @default.
• W4285087689 cites W2103245465 @default.
• W4285087689 cites W2109397102 @default.
• W4285087689 cites W2138045682 @default.
• W4285087689 cites W2144706342 @default.
• W4285087689 cites W2146526868 @default.
• W4285087689 cites W2166023752 @default.
• W4285087689 cites W2277004004 @default.
• W4285087689 cites W2415484267 @default.
• W4285087689 cites W2464352977 @default.
• W4285087689 cites W2566109146 @default.
• W4285087689 cites W2592956618 @default.
• W4285087689 cites W2608303021 @default.
• W4285087689 cites W2743333579 @default.
• W4285087689 cites W2761321759 @default.
• W4285087689 cites W2791209060 @default.
• W4285087689 cites W2796067155 @default.
• W4285087689 cites W2948314755 @default.
• W4285087689 cites W2991557664 @default.
• W4285087689 cites W3010788944 @default.
• W4285087689 cites W3012839541 @default.
• W4285087689 cites W3099699096 @default.
• W4285087689 cites W3121807241 @default.
• W4285087689 cites W3127415255 @default.
• W4285087689 cites W3132169793 @default.
• W4285087689 cites W3197465212 @default.
• W4285087689 cites W3204303963 @default.
• W4285087689 cites W4200219024 @default.
• W4285087689 cites W4200500886 @default.
• W4285087689 cites W4243625103 @default.
• W4285087689 cites W4376848320 @default.
• W4285087689 doi "https://doi.org/10.3389/fonc.2022.869316" @default.
• W4285087689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35912221" @default.
• W4285087689 hasPublicationYear "2022" @default.
• W4285087689 type Work @default.
• W4285087689 citedByCount "5" @default.
• W4285087689 countsByYear W42850876892023 @default.
• W4285087689 crossrefType "journal-article" @default.
• W4285087689 hasAuthorship W4285087689A5003281764 @default.
• W4285087689 hasAuthorship W4285087689A5008047814 @default.
• W4285087689 hasAuthorship W4285087689A5010137279 @default.
• W4285087689 hasAuthorship W4285087689A5016874780 @default.
• W4285087689 hasAuthorship W4285087689A5024944236 @default.
• W4285087689 hasAuthorship W4285087689A5025283381 @default.
• W4285087689 hasAuthorship W4285087689A5036565708 @default.
• W4285087689 hasAuthorship W4285087689A5039615242 @default.
• W4285087689 hasAuthorship W4285087689A5088539918 @default.
• W4285087689 hasBestOaLocation W42850876891 @default.
• W4285087689 hasConcept C104317684 @default.
• W4285087689 hasConcept C126322002 @default.
• W4285087689 hasConcept C141071460 @default.
• W4285087689 hasConcept C143998085 @default.
• W4285087689 hasConcept C185592680 @default.
• W4285087689 hasConcept C186852380 @default.
• W4285087689 hasConcept C197934379 @default.
• W4285087689 hasConcept C2778019345 @default.
• W4285087689 hasConcept C2778716261 @default.
• W4285087689 hasConcept C2778902805 @default.
• W4285087689 hasConcept C502942594 @default.
• W4285087689 hasConcept C535046627 @default.
• W4285087689 hasConcept C55493867 @default.
• W4285087689 hasConcept C71924100 @default.
• W4285087689 hasConceptScore W4285087689C104317684 @default.
• W4285087689 hasConceptScore W4285087689C126322002 @default.
• W4285087689 hasConceptScore W4285087689C141071460 @default.
• W4285087689 hasConceptScore W4285087689C143998085 @default.
• W4285087689 hasConceptScore W4285087689C185592680 @default.
• W4285087689 hasConceptScore W4285087689C186852380 @default.
• W4285087689 hasConceptScore W4285087689C197934379 @default.
• W4285087689 hasConceptScore W4285087689C2778019345 @default.
• W4285087689 hasConceptScore W4285087689C2778716261 @default.
• W4285087689 hasConceptScore W4285087689C2778902805 @default.
• W4285087689 hasConceptScore W4285087689C502942594 @default.
• W4285087689 hasConceptScore W4285087689C535046627 @default.
• W4285087689 hasConceptScore W4285087689C55493867 @default.
• W4285087689 hasConceptScore W4285087689C71924100 @default.
• W4285087689 hasFunder F4320321001 @default.

• next